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Lisa E. Gralinski
Lisa E. Gralinski
Department of Epidemiology, University of North Carolina
Verifierad e-postadress på email.unc.edu - Startsida
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Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
TP Sheahan, AC Sims, RL Graham, VD Menachery, LE Gralinski, ...
Science translational medicine 9 (396), eaal3653, 2017
18322017
Return of the Coronavirus: 2019-nCoV
LE Gralinski, VD Menachery
Viruses 12 (2), 135, 2020
17862020
SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory tract
YJ Hou, K Okuda, CE Edwards, DR Martinez, T Asakura, KH Dinnon, ...
Cell 182 (2), 429-446. e14, 2020
14702020
A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence
VD Menachery, BL Yount, K Debbink, S Agnihothram, LE Gralinski, ...
Nature medicine 21 (12), 1508-1513, 2015
11522015
Potently neutralizing and protective human antibodies against SARS-CoV-2
SJ Zost, P Gilchuk, JB Case, E Binshtein, RE Chen, JP Nkolola, A Schäfer, ...
Nature 584 (7821), 443-449, 2020
10482020
SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo
YJ Hou, S Chiba, P Halfmann, C Ehre, M Kuroda, KH Dinnon III, SR Leist, ...
Science 370 (6523), 1464-1468, 2020
9002020
Animal models for COVID-19
C Muñoz-Fontela, WE Dowling, SGP Funnell, PS Gsell, AX Riveros-Balta, ...
Nature 586 (7830), 509-515, 2020
7962020
A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures
KH Dinnon III, SR Leist, A Schäfer, CE Edwards, DR Martinez, ...
Nature 586 (7830), 560-566, 2020
6502020
Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis
LE Gralinski, TP Sheahan, TE Morrison, VD Menachery, K Jensen, ...
MBio 9 (5), 10.1128/mbio. 01753-18, 2018
5992018
A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary …
M Bolles, D Deming, K Long, S Agnihothram, A Whitmore, M Ferris, ...
Journal of virology 85 (23), 12201-12215, 2011
5812011
A single-dose intranasal ChAd vaccine protects upper and lower respiratory tracts against SARS-CoV-2
AO Hassan, NM Kafai, IP Dmitriev, JM Fox, BK Smith, IB Harvey, RE Chen, ...
Cell 183 (1), 169-184. e13, 2020
4952020
A mouse-adapted SARS-CoV-2 induces acute lung injury and mortality in standard laboratory mice
SR Leist, KH Dinnon, A Schäfer, VT Longping, K Okuda, YJ Hou, A West, ...
Cell 183 (4), 1070-1085. e12, 2020
4872020
Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice
AJ Pruijssers, AS George, A Schäfer, SR Leist, LE Gralinksi, KH Dinnon, ...
Cell reports 32 (3), 2020
4812020
SARS-like WIV1-CoV poised for human emergence
VD Menachery, BL Yount Jr, AC Sims, K Debbink, SS Agnihothram, ...
Proceedings of the National Academy of Sciences 113 (11), 3048-3053, 2016
4482016
Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2
AC Walls, B Fiala, A Schäfer, S Wrenn, MN Pham, M Murphy, ...
Cell 183 (5), 1367-1382. e17, 2020
4462020
Molecular pathology of emerging coronavirus infections
LE Gralinski, RS Baric
The Journal of pathology 235 (2), 185-195, 2015
4412015
SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801
A Wahl, LE Gralinski, CE Johnson, W Yao, M Kovarova, KH Dinnon III, ...
Nature 591 (7850), 451-457, 2021
3822021
Genetic analysis of complex traits in the emerging Collaborative Cross
DL Aylor, W Valdar, W Foulds-Mathes, RJ Buus, RA Verdugo, RS Baric, ...
Genome research 21 (8), 1213-1222, 2011
3732011
Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus
L Josset, VD Menachery, LE Gralinski, S Agnihothram, P Sova, VS Carter, ...
MBio 4 (3), 10.1128/mbio. 00165-13, 2013
2902013
Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody
CG Rappazzo, LV Tse, CI Kaku, D Wrapp, M Sakharkar, D Huang, ...
Science 371 (6531), 823-829, 2021
2832021
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