| Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies H Kim, M Rafiuddin-Shah, HC Tu, JR Jeffers, GP Zambetti, JJD Hsieh, ... Nature cell biology 8 (12), 1348-1358, 2006 | 1087 | 2006 |
| BAX activation is initiated at a novel interaction site E Gavathiotis, M Suzuki, ML Davis, K Pitter, GH Bird, SG Katz, HC Tu, ... Nature 455 (7216), 1076-1081, 2008 | 843 | 2008 |
| Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis H Kim, HC Tu, D Ren, O Takeuchi, JR Jeffers, GP Zambetti, JJD Hsieh, ... Molecular cell 36 (3), 487-499, 2009 | 698 | 2009 |
| BID, BIM, and PUMA are essential for activation of the BAX-and BAK-dependent cell death program D Ren, HC Tu, H Kim, GX Wang, GR Bean, O Takeuchi, JR Jeffers, ... Science 330 (6009), 1390-1393, 2010 | 544 | 2010 |
| An interconnected hierarchical model of cell death regulation by the BCL-2 family HC Chen, M Kanai, A Inoue-Yamauchi, HC Tu, Y Huang, D Ren, H Kim, ... Nature cell biology 17 (10), 1270-1281, 2015 | 291 | 2015 |
| Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma JT Powers, KM Tsanov, DS Pearson, F Roels, CS Spina, R Ebright, ... Nature 535 (7611), 246-251, 2016 | 188 | 2016 |
| The polyploid state plays a tumor-suppressive role in the liver S Zhang, K Zhou, X Luo, L Li, HC Tu, A Sehgal, LH Nguyen, Y Zhang, ... Developmental cell 44 (4), 447-459. e5, 2018 | 175 | 2018 |
| The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage HC Tu, D Ren, GX Wang, DY Chen, TD Westergard, H Kim, S Sasagawa, ... Proceedings of the National Academy of Sciences 106 (4), 1093-1098, 2009 | 121 | 2009 |
| LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans HC Tu, S Schwitalla, Z Qian, GS LaPier, A Yermalovich, YC Ku, SC Chen, ... Genes & development 29 (10), 1074-1086, 2015 | 116 | 2015 |
| Knockdown of anillin actin binding protein blocks cytokinesis in hepatocytes and reduces liver tumor development in mice without affecting regeneration S Zhang, LH Nguyen, K Zhou, HC Tu, A Sehgal, I Nassour, L Li, P Gopal, ... Gastroenterology 154 (5), 1421-1434, 2018 | 108 | 2018 |
| ΔNp63 inhibits oxidative stress-induced cell death, including ferroptosis, and cooperates with the BCL-2 family to promote clonogenic survival GX Wang, HC Tu, Y Dong, AJ Skanderup, Y Wang, S Takeda, ... Cell reports 21 (10), 2926-2939, 2017 | 67 | 2017 |
| Interferon-α signaling promotes embryonic HSC maturation PG Kim, MC Canver, C Rhee, SJ Ross, JV Harriss, HC Tu, SH Orkin, ... Blood, The Journal of the American Society of Hematology 128 (2), 204-216, 2016 | 56 | 2016 |
| The VDAC2-BAK rheostat controls thymocyte survival D Ren, H Kim, HC Tu, TD Westergard, JK Fisher, JA Rubens, ... Science signaling 2 (85), ra48-ra48, 2009 | 56 | 2009 |
| Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis DY Chen, H Liu, S Takeda, HC Tu, S Sasagawa, BA Van Tine, D Lu, ... Cancer research 70 (13), 5358-5367, 2010 | 53 | 2010 |
| Failure to replicate the STAP cell phenomenon A De Los Angeles, F Ferrari, Y Fujiwara, R Mathieu, S Lee, S Lee, HC Tu, ... Nature 525 (7570), E6-E9, 2015 | 51 | 2015 |
| A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth DY Chen, Y Lee, BA Van Tine, AC Searleman, TD Westergard, H Liu, ... Cancer research 72 (3), 736-746, 2012 | 49 | 2012 |
| Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation JH Weng, PD Koch, HH Luan, HC Tu, K Shimada, I Ngan, R Ventura, ... Nature metabolism 3 (4), 513-522, 2021 | 42 | 2021 |
| GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms LD Ward, HC Tu, CB Quenneville, S Tsour, AO Flynn-Carroll, MM Parker, ... Nature Communications 12 (1), 4571, 2021 | 25 | 2021 |
| Loss of bound zinc facilitates amyloid fibril formation of leukocyte-cell-derived chemotaxin 2 (LECT2) JH Ha, HC Tu, S Wilkens, SN Loh Journal of Biological Chemistry 296, 2021 | 18 | 2021 |
| Delving into the amyloidogenic core of human leukocyte chemotactic factor 2 PL Tsiolaki, GI Nasi, FA Baltoumas, S Fishman, HC Tu, VA Iconomidou Journal of Structural Biology 207 (3), 260-269, 2019 | 11 | 2019 |
