Rimas J Orentas
Rimas J Orentas
Caring Cross
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T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial
DW Lee, JN Kochenderfer, M Stetler-Stevenson, YK Cui, C Delbrook, ...
The Lancet 385 (9967), 517-528, 2015
4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors
AH Long, WM Haso, JF Shern, KM Wanhainen, M Murgai, M Ingaramo, ...
Nature medicine 21 (6), 581-590, 2015
CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy
TJ Fry, NN Shah, RJ Orentas, M Stetler-Stevenson, CM Yuan, ...
Nature medicine 24 (1), 20-28, 2018
Anti-CD22–chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia
W Haso, DW Lee, NN Shah, M Stetler-Stevenson, CM Yuan, IH Pastan, ...
Blood, The Journal of the American Society of Hematology 121 (7), 1165-1174, 2013
CAR T cells targeting B7-H3, a pan-cancer antigen, demonstrate potent preclinical activity against pediatric solid tumors and brain tumors
RG Majzner, JL Theruvath, A Nellan, S Heitzeneder, Y Cui, CW Mount, ...
Clinical Cancer Research 25 (8), 2560-2574, 2019
Involvement of a leukocyte adhesion receptor (LFA-1) in HIV-induced syncytium formation
JEK Hildreth, RJ Orentas
Science 244 (4908), 1075-1078, 1989
Bispecific anti-CD20, anti-CD19 CAR T cells for relapsed B cell malignancies: a phase 1 dose escalation and expansion trial
NN Shah, BD Johnson, D Schneider, F Zhu, A Szabo, CA Keever-Taylor, ...
Nature medicine 26 (10), 1569-1575, 2020
Tumor antigen and receptor densities regulate efficacy of a chimeric antigen receptor targeting anaplastic lymphoma kinase
AJ Walker, RG Majzner, L Zhang, K Wanhainen, AH Long, SM Nguyen, ...
Molecular Therapy 25 (9), 2189-2201, 2017
Reduction of MDSCs with all-trans retinoic acid improves CAR therapy efficacy for sarcomas
AH Long, SL Highfill, Y Cui, JP Smith, AJ Walker, S Ramakrishna, ...
Cancer immunology research 4 (10), 869-880, 2016
CD19 CAR T cell product and disease attributes predict leukemia remission durability
OC Finney, H Brakke, S Rawlings-Rhea, R Hicks, D Doolittle, M Lopez, ...
The Journal of clinical investigation 129 (5), 2123-2132, 2019
A tandem CD19/CD20 CAR lentiviral vector drives on-target and off-target antigen modulation in leukemia cell lines
D Schneider, Y Xiong, D Wu, V Nӧlle, S Schmitz, W Haso, A Kaiser, ...
Journal for immunotherapy of cancer 5, 1-17, 2017
Association of host cell surface adhesion receptors and other membrane proteins with HIV and SIV
AIDS research and human retroviruses 9 (11), 1157-1165, 1993
Towards a commercial process for the manufacture of genetically modified T cells for therapy
AD Kaiser, M Assenmacher, B Schröder, M Meyer, R Orentas, U Bethke, ...
Cancer gene therapy 22 (2), 72-78, 2015
Induction of CD4+ Human Cytolytic T Cells Specific for HIV-Infected Cells by a Gp160 Subunit Vaccine
RJ Orentas, JEK Hildreth, E Obah, M Polydefkis, GE Smith, ML Clements, ...
Science 248 (4960), 1234-1237, 1990
Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis
NA Vitanza, AJ Johnson, AL Wilson, C Brown, JK Yokoyama, A Künkele, ...
Nature medicine 27 (9), 1544-1552, 2021
Fibrocytes represent a novel MDSC subset circulating in patients with metastatic cancer
H Zhang, I Maric, MJ DiPrima, J Khan, RJ Orentas, RN Kaplan, ...
Blood, The Journal of the American Society of Hematology 122 (7), 1105-1113, 2013
The future is now: chimeric antigen receptors as new targeted therapies for childhood cancer
DW Lee, DM Barrett, C Mackall, R Orentas, SA Grupp
Clinical Cancer Research 18 (10), 2780-2790, 2012
Identification of cell surface proteins as potential immunotherapy targets in 12 pediatric cancers
RJ Orentas, JJ Yang, X Wen, JS Wei, CL Mackall, J Khan
Frontiers in oncology 2, 194, 2012
Eradication of B-ALL using chimeric antigen receptor–expressing T cells targeting the TSLPR oncoprotein
H Qin, M Cho, W Haso, L Zhang, SK Tasian, HZ Oo, GL Negri, Y Lin, ...
Blood, The Journal of the American Society of Hematology 126 (5), 629-639, 2015
Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model
K Anthony-Gonda, A Bardhi, A Ray, N Flerin, M Li, W Chen, ...
Science translational medicine 11 (504), eaav5685, 2019
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