P Nuno Palma
P Nuno Palma
BIAL, Dept. R&D
Verifierad e-postadress på bial.com
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BiGGER: a new (soft) docking algorithm for predicting protein interactions
PN Palma, L Krippahl, JE Wampler, JJG Moura
Proteins: Structure, Function, and Bioinformatics 39 (4), 372-384, 2000
3732000
Catechol‐O‐methyltransferase and Its Inhibitors in Parkinson's Disease
MJ Bonifácio, PN Palma, L Almeida, P Soares‐da‐Silva
CNS drug reviews 13 (3), 352-379, 2007
1982007
Discovery of a Long-Acting, Peripherally Selective Inhibitor of Catechol-O-methyltransferase
LE Kiss, HS Ferreira, L Torrao, MJ Bonifácio, PN Palma, ...
Journal of medicinal chemistry 53 (8), 3396-3411, 2010
1462010
Eslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: a comparison with carbamazepine, oxcarbazepine and lacosamide
S Hebeisen, N Pires, AI Loureiro, MJ Bonifácio, N Palma, A Whyment, ...
Neuropharmacology 89, 122-135, 2015
972015
Heteronuclear NMR and Soft Docking:  An Experimental Approach for a Structural Model of the Cytochrome c553−Ferredoxin Complex
X Morelli, A Dolla, M Czjzek, PN Palma, F Blasco, L Krippahl, JJG Moura, ...
Biochemistry 39 (10), 2530-2537, 2000
782000
Structure of the tetraheme cytochrome from Desulfovibrio desulfuricans ATCC 27774: X-ray diffraction and electron paramagnetic resonance studies
J Morais, PN Palma, C Frazao, J Caldeira, J LeGall, I Moura, JJG Moura, ...
Biochemistry 34 (39), 12830-12841, 1995
751995
A novel approach for assesing macromolecular complexes combining soft‐docking calculations with NMR data
XJ Morelli, PN Palma, F Guerlesquin, AC Rigby
Protein Science 10 (10), 2131-2137, 2001
692001
Pharmacokinetics, Pharmacodynamics and Tolerability of Opicapone, a Novel Catechol-O-Methyltransferase Inhibitor, in Healthy Subjects
L Almeida, JF Rocha, A Falcão, PN Palma, AI Loureiro, R Pinto, ...
Clinical pharmacokinetics 52 (2), 139-151, 2013
672013
Opicapone: a short lived and very long acting novel catechol‐O‐methyltransferase inhibitor following multiple dose administration in healthy subjects
JF Rocha, L Almeida, A Falcão, PN Palma, AI Loureiro, R Pinto, ...
British journal of clinical pharmacology 76 (5), 763-775, 2013
612013
Modeling protein complexes with BiGGER
L Krippahl, JJ Moura, PN Palma
Proteins: Structure, Function, and Bioinformatics 52 (1), 19-23, 2003
592003
Eslicarbazepine acetate for the treatment of focal epilepsy: an update on its proposed mechanisms of action
P Soares‐da‐Silva, N Pires, MJ Bonifácio, AI Loureiro, N Palma, ...
Pharmacology research & perspectives 3 (2), e00124, 2015
562015
Structural Model of the Fe-Hydrogenase/Cytochromec 553 Complex Combining Transverse Relaxation-optimized Spectroscopy Experiments and Soft Docking Calculations
X Morelli, M Czjzek, CE Hatchikian, O Bornet, JC Fontecilla-Camps, ...
Journal of Biological Chemistry 275 (30), 23204-23210, 2000
562000
Effects of iontophoresis of noradrenaline and stimulation of the periaqueductal gray on single‐unit activity in the rat superficial dorsal horn
J Millar, GV Williams
Journal of Comparative Neurology 287 (1), 119-133, 1989
551989
Comparative study of ortho-and meta-nitrated inhibitors of catechol-O-methyltransferase: interactions with the active site and regioselectivity of O-methylation
PN Palma, ML Rodrigues, M Archer, MJ Bonifacio, AI Loureiro, ...
Molecular pharmacology 70 (1), 143-153, 2006
502006
Synthesis, biological evaluation, and molecular modeling studies of a novel, peripherally selective inhibitor of catechol-O-methyltransferase
DA Learmonth, PN Palma, MA Vieira-Coelho, P Soares-da-Silva
Journal of medicinal chemistry 47 (25), 6207-6217, 2004
492004
Computation of the binding affinities of catechol‐O‐methyltransferase inhibitors: Multisubstate relative free energy calculations
P Nuno Palma, M João Bonifácio, A Isabel Loureiro, P Soares‐da‐Silva
Journal of Computational Chemistry, 2012
462012
Molecular modeling and metabolic studies of the interaction of catechol-O-methyltransferase and a new nitrocatechol inhibitor
PN Palma, MJ Bonifacio, AI Loureiro, LC Wright, DA Learmonth, ...
Drug metabolism and disposition 31 (3), 250-258, 2003
462003
Pharmacological profile of opicapone, a third‐generation nitrocatechol catechol‐O‐methyl transferase inhibitor, in the rat
MJ Bonifacio, L Torrao, AI Loureiro, PN Palma, LC Wright, ...
British journal of pharmacology 172 (7), 1739-1752, 2015
422015
Tumor-promoting and nonpromoting proinflammatory esters act as human lymphocyte mitogens with different sensitivities to inhibition by cyclosporin A.
MC Edwards, AM Nouri, D Gordon, FJ Evans
Molecular pharmacology 23 (3), 703-708, 1983
41*1983
The structure of an electron transfer complex containing a cytochrome c and a peroxidase
GW Pettigrew, S Prazeres, C Costa, N Palma, L Krippahl, I Moura, ...
Journal of Biological Chemistry 274 (16), 11383-11389, 1999
391999
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Artiklar 1–20