|BiGGER: a new (soft) docking algorithm for predicting protein interactions|
PN Palma, L Krippahl, JE Wampler, JJG Moura
Proteins: Structure, Function, and Bioinformatics 39 (4), 372-384, 2000
|Catechol‐O‐methyltransferase and Its Inhibitors in Parkinson's Disease|
MJ Bonifácio, PN Palma, L Almeida, P Soares‐da‐Silva
CNS drug reviews 13 (3), 352-379, 2007
|Discovery of a Long-Acting, Peripherally Selective Inhibitor of Catechol-O-methyltransferase|
LE Kiss, HS Ferreira, L Torrao, MJ Bonifácio, PN Palma, ...
Journal of medicinal chemistry 53 (8), 3396-3411, 2010
|Eslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: a comparison with carbamazepine, oxcarbazepine and lacosamide|
S Hebeisen, N Pires, AI Loureiro, MJ Bonifácio, N Palma, A Whyment, ...
Neuropharmacology 89, 122-135, 2015
|Heteronuclear NMR and Soft Docking: An Experimental Approach for a Structural Model of the Cytochrome c553−Ferredoxin Complex|
X Morelli, A Dolla, M Czjzek, PN Palma, F Blasco, L Krippahl, JJG Moura, ...
Biochemistry 39 (10), 2530-2537, 2000
|Structure of the tetraheme cytochrome from Desulfovibrio desulfuricans ATCC 27774: X-ray diffraction and electron paramagnetic resonance studies|
J Morais, PN Palma, C Frazao, J Caldeira, J LeGall, I Moura, JJG Moura, ...
Biochemistry 34 (39), 12830-12841, 1995
|A novel approach for assesing macromolecular complexes combining soft‐docking calculations with NMR data|
XJ Morelli, PN Palma, F Guerlesquin, AC Rigby
Protein Science 10 (10), 2131-2137, 2001
|Pharmacokinetics, Pharmacodynamics and Tolerability of Opicapone, a Novel Catechol-O-Methyltransferase Inhibitor, in Healthy Subjects|
L Almeida, JF Rocha, A Falcão, PN Palma, AI Loureiro, R Pinto, ...
Clinical pharmacokinetics 52 (2), 139-151, 2013
|Opicapone: a short lived and very long acting novel catechol‐O‐methyltransferase inhibitor following multiple dose administration in healthy subjects|
JF Rocha, L Almeida, A Falcão, PN Palma, AI Loureiro, R Pinto, ...
British journal of clinical pharmacology 76 (5), 763-775, 2013
|Modeling protein complexes with BiGGER|
L Krippahl, JJ Moura, PN Palma
Proteins: Structure, Function, and Bioinformatics 52 (1), 19-23, 2003
|Eslicarbazepine acetate for the treatment of focal epilepsy: an update on its proposed mechanisms of action|
P Soares‐da‐Silva, N Pires, MJ Bonifácio, AI Loureiro, N Palma, ...
Pharmacology research & perspectives 3 (2), e00124, 2015
|Structural Model of the Fe-Hydrogenase/Cytochromec 553 Complex Combining Transverse Relaxation-optimized Spectroscopy Experiments and Soft Docking Calculations|
X Morelli, M Czjzek, CE Hatchikian, O Bornet, JC Fontecilla-Camps, ...
Journal of Biological Chemistry 275 (30), 23204-23210, 2000
|Effects of iontophoresis of noradrenaline and stimulation of the periaqueductal gray on single‐unit activity in the rat superficial dorsal horn|
J Millar, GV Williams
Journal of Comparative Neurology 287 (1), 119-133, 1989
|Comparative study of ortho-and meta-nitrated inhibitors of catechol-O-methyltransferase: interactions with the active site and regioselectivity of O-methylation|
PN Palma, ML Rodrigues, M Archer, MJ Bonifacio, AI Loureiro, ...
Molecular pharmacology 70 (1), 143-153, 2006
|Synthesis, biological evaluation, and molecular modeling studies of a novel, peripherally selective inhibitor of catechol-O-methyltransferase|
DA Learmonth, PN Palma, MA Vieira-Coelho, P Soares-da-Silva
Journal of medicinal chemistry 47 (25), 6207-6217, 2004
|Computation of the binding affinities of catechol‐O‐methyltransferase inhibitors: Multisubstate relative free energy calculations|
P Nuno Palma, M João Bonifácio, A Isabel Loureiro, P Soares‐da‐Silva
Journal of Computational Chemistry, 2012
|Molecular modeling and metabolic studies of the interaction of catechol-O-methyltransferase and a new nitrocatechol inhibitor|
PN Palma, MJ Bonifacio, AI Loureiro, LC Wright, DA Learmonth, ...
Drug metabolism and disposition 31 (3), 250-258, 2003
|Pharmacological profile of opicapone, a third‐generation nitrocatechol catechol‐O‐methyl transferase inhibitor, in the rat|
MJ Bonifacio, L Torrao, AI Loureiro, PN Palma, LC Wright, ...
British journal of pharmacology 172 (7), 1739-1752, 2015
|Tumor-promoting and nonpromoting proinflammatory esters act as human lymphocyte mitogens with different sensitivities to inhibition by cyclosporin A.|
MC Edwards, AM Nouri, D Gordon, FJ Evans
Molecular pharmacology 23 (3), 703-708, 1983
|The structure of an electron transfer complex containing a cytochrome c and a peroxidase|
GW Pettigrew, S Prazeres, C Costa, N Palma, L Krippahl, I Moura, ...
Journal of Biological Chemistry 274 (16), 11383-11389, 1999