Ayaz Najafov
Ayaz Najafov
Harvard Medical School
Verified email at hms.harvard.edu
Cited by
Cited by
Activation of necroptosis in multiple sclerosis
D Ofengeim, Y Ito, A Najafov, Y Zhang, B Shan, JP DeWitt, J Ye, X Zhang, ...
Cell reports 10 (11), 1836-1849, 2015
RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS
Y Ito, D Ofengeim, A Najafov, S Das, S Saberi, Y Li, J Hitomi, H Zhu, ...
Science 353 (6299), 603-608, 2016
Roles of caspases in necrotic cell death
J Yuan, A Najafov, BF Py
Cell 167 (7), 1693-1704, 2016
Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1
A Najafov, EM Sommer, JM Axten, MP DeYoung, DR Alessi
Biochemical Journal 433 (2), 357-369, 2011
Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis
J Geng, Y Ito, L Shi, P Amin, J Chu, AT Ouchida, AK Mookhtiar, H Zhao, ...
Nature communications 8 (1), 1-12, 2017
The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans
ML Landsverk, S Li, AH Hutagalung, A Najafov, T Hoppe, JM Barral, ...
The Journal of cell biology 177 (2), 205-210, 2007
Necroptosis in development and diseases
B Shan, H Pan, A Najafov, J Yuan
Genes & development 32 (5-6), 327-340, 2018
Clinicopathological and genetic study of early-onset demyelinating neuropathy
Y Parman, E Battaloğlu, I Barış, B Bilir, M Poyraz, N Bissar-Tadmouri, ...
Brain 127 (11), 2540, 2004
Akt is efficiently activated by PIF-pocket-and PtdIns (3, 4, 5) P3-dependent mechanisms leading to resistance to PDK1 inhibitors
A Najafov, N Shpiro, DR Alessi
Biochemical Journal 448 (2), 285-295, 2012
Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death
H Xia, A Najafov, J Geng, L Galan-Acosta, X Han, Y Guo, B Shan, ...
Journal of Cell Biology 210 (5), 705-716, 2015
G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L
T Zhang, K Dong, W Liang, D Xu, H Xia, J Geng, A Najafov, M Liu, Y Li, ...
Elife 4, e06734, 2015
Necroptosis and cancer
A Najafov, H Chen, J Yuan
Trends in cancer 3 (4), 294-301, 2017
Uncoupling the Warburg effect from cancer
A Najafov, DR Alessi
Proceedings of the National Academy of Sciences 107 (45), 19135-19136, 2010
Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis
P Amin, M Florez, A Najafov, H Pan, J Geng, D Ofengeim, SA Dziedzic, ...
Proceedings of the National Academy of Sciences 115 (26), E5944-E5953, 2018
ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC
SA Dziedzic, Z Su, VJ Barrett, A Najafov, AK Mookhtiar, P Amin, H Pan, ...
Nature cell biology 20 (1), 58-68, 2018
PDK1 regulates VDJ recombination, cell‐cycle exit and survival during B‐cell development
RKC Venigalla, VA McGuire, R Clarke, JC Patterson‐Kane, A Najafov, ...
The EMBO journal 32 (7), 1008-1022, 2013
ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ ATPase
G Hoxhaj, A Najafov, R Toth, DG Campbell, AR Prescott, C MacKintosh
Journal of cell science 125 (19), 4662-4675, 2012
TAM kinases promote necroptosis by regulating oligomerization of MLKL
A Najafov, AK Mookhtiar, HS Luu, A Ordureau, H Pan, PP Amin, Y Li, Q Lu, ...
Molecular cell 75 (3), 457-468. e4, 2019
MENA is a transcriptional target of the Wnt/beta-catenin pathway
A Najafov, T Şeker, İ Even, G Hoxhaj, O Selvi, DE Özel, A Koman, ...
PLoS One 7 (5), e37013, 2012
Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets
E Kavak, A Najafov, N Ozturk, T Seker, K Cavusoglu, T Aslan, AD Duru, ...
Cellular signalling 22 (10), 1523-1535, 2010
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