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Tudor Oprea
Tudor Oprea
VP, Translational Informatics, Roivant Discovery Sciences
Verifierad e-postadress på roivant.com - Startsida
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A comprehensive map of molecular drug targets
R Santos, O Ursu, A Gaulton, AP Bento, RS Donadi, CG Bologa, ...
Nature reviews Drug discovery 16 (1), 19-34, 2017
15872017
Is There a Difference Between Leads and Drugs? A Historical Perspective.
TI Oprea, AM Davis, SJ Teague, PD Leeson
Journal of chemical information and computer sciences 41 (5), 1308-1315, 2001
9532001
The design of leadlike combinatorial libraries
SJ Teague, AM Davis, PD Leeson, T Oprea
Angewandte Chemie International Edition 38 (24), 3743-3748, 1999
9371999
Virtual and biomolecular screening converge on a selective agonist for GPR30
CG Bologa, CM Revankar, SM Young, BS Edwards, JB Arterburn, ...
Nature chemical biology 2 (4), 207-212, 2006
8552006
Estrogen signaling through the transmembrane G protein-coupled receptor GPR30
ER Prossnitz, JB Arterburn, HO Smith, TI Oprea, LA Sklar, HJ Hathaway
Annual review of physiology 70 (1), 165-190, 2008
7222008
Property distribution of drug-related chemical databases
TI Oprea
Journal of computer-aided molecular design 14 (3), 251-264, 2000
7042000
BDDCS applied to over 900 drugs
LZ Benet, F Broccatelli, TI Oprea
The AAPS journal 13 (4), 519-547, 2011
6092011
Pursuing the leadlikeness concept in pharmaceutical research
MM Hann, TI Oprea
Current opinion in chemical biology 8 (3), 255-263, 2004
6082004
In vivo effects of a GPR30 antagonist
MK Dennis, R Burai, C Ramesh, WK Petrie, SN Alcon, TK Nayak, ...
Nature chemical biology 5 (6), 421-427, 2009
5492009
Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system
E Brailoiu, SL Dun, GC Brailoiu, K Mizuo, LA Sklar, TI Oprea, ER Prossnitz, ...
Journal of endocrinology 193 (2), 311-321, 2007
5432007
G protein–coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17β-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells
L Albanito, A Madeo, R Lappano, A Vivacqua, V Rago, A Carpino, ...
Cancer research 67 (4), 1859-1866, 2007
4842007
BDDCS, the Rule of 5 and drugability
LZ Benet, CM Hosey, O Ursu, TI Oprea
Advanced drug delivery reviews 101, 89-98, 2016
4222016
Chemography: the art of navigating in chemical space
TI Oprea, J Gottfries
Journal of combinatorial chemistry 3 (2), 157-166, 2001
3692001
Integrating virtual screening in lead discovery
TI Oprea, H Matter
Current opinion in chemical biology 8 (4), 349-358, 2004
3592004
VALIDATE: A new method for the receptor-based prediction of binding affinities of novel ligands
RD Head, ML Smythe, TI Oprea, CL Waller, SM Green, GR Marshall
Journal of the American Chemical society 118 (16), 3959-3969, 1996
3351996
QSAR without borders
EN Muratov, J Bajorath, RP Sheridan, IV Tetko, D Filimonov, V Poroikov, ...
Chemical Society Reviews 49 (11), 3525-3564, 2020
3342020
Temporal disease trajectories condensed from population-wide registry data covering 6.2 million patients
AB Jensen, PL Moseley, TI Oprea, SG Ellesøe, R Eriksson, H Schmock, ...
Nature communications 5 (1), 1-10, 2014
3212014
Current trends in lead discovery: Are we looking at the appropriate property
TI Oprea
Journal of computer-aided molecular design 16 (5-6), 325-334, 2002
313*2002
Drug repurposing from an academic perspective
TI Oprea, JE Bauman, CG Bologa, T Buranda, A Chigaev, BS Edwards, ...
Drug Discovery Today: Therapeutic Strategies 8 (3-4), 61-69, 2011
3072011
Novel chemical space exploration via natural products
J Rosén, J Gottfries, S Muresan, A Backlund, TI Oprea
Journal of medicinal chemistry 52 (7), 1953-1962, 2009
3032009
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Artiklar 1–20