Justin Bloomfield Siegel
Justin Bloomfield Siegel
Associate Professor, UC Davis
Verified email at ucdavis.edu - Homepage
Title
Cited by
Cited by
Year
Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction
JB Siegel, A Zanghellini, HM Lovick, G Kiss, AR Lambert, JLS Clair, ...
Science 329 (5989), 309-313, 2010
8502010
Increased Diels-Alderase activity through backbone remodeling guided by Foldit players
CB Eiben, JB Siegel, JB Bale, S Cooper, F Khatib, BW Shen, BL Stoddard, ...
Nature biotechnology 30 (2), 190-192, 2012
2992012
Computational protein design enables a novel one-carbon assimilation pathway
JB Siegel, AL Smith, S Poust, AJ Wargacki, A Bar-Even, C Louw, ...
Proceedings of the National Academy of Sciences 112 (12), 3704-3709, 2015
1752015
Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase
N Preiswerk, T Beck, JD Schulz, P Milovník, C Mayer, JB Siegel, D Baker, ...
Proceedings of the National Academy of Sciences 111 (22), 8013-8018, 2014
1052014
Computational design of an α-gliadin peptidase
SR Gordon, EJ Stanley, S Wolf, A Toland, SJ Wu, D Hadidi, JH Mills, ...
Journal of the American Chemical Society 134 (50), 20513-20520, 2012
932012
Expanding the product profile of a microbial alkane biosynthetic pathway
M Harger, L Zheng, A Moon, C Ager, JH An, C Choe, YL Lai, B Mo, ...
ACS synthetic biology 2 (1), 59-62, 2013
752013
Computational enzyme design: Transitioning from catalytic proteins to enzymes
WS Mak, JB Siegel
Current opinion in structural biology 27, 87-94, 2014
532014
Integrative genomic mining for enzyme function to enable engineering of a non-natural biosynthetic pathway
WS Mak, S Tran, R Marcheschi, S Bertolani, J Thompson, D Baker, ...
Nature communications 6 (1), 1-10, 2015
522015
Engineering of Kuma030: a gliadin peptidase that rapidly degrades immunogenic gliadin peptides in gastric conditions
C Wolf, JB Siegel, C Tinberg, A Camarca, C Gianfrani, S Paski, R Guan, ...
Journal of the American Chemical Society 137 (40), 13106-13113, 2015
522015
Foldit Standalone: a video game-derived protein structure manipulation interface using Rosetta
R Kleffner, J Flatten, A Leaver-Fay, D Baker, JB Siegel, F Khatib, ...
Bioinformatics 33 (17), 2765-2767, 2017
502017
Biofuel production
Y Kashiyama, Y Yoshikuni, D Baker, JB Siegel
US Patent App. 12/245,540, 2009
502009
Mechanistically informed predictions of binding modes for carbocation intermediates of a sesquiterpene synthase reaction
TE O'Brien, SJ Bertolani, DJ Tantillo, JB Siegel
Chemical science 7 (7), 4009-4015, 2016
322016
Macromolecular modeling and design in Rosetta: recent methods and frameworks
JK Leman, BD Weitzner, SM Lewis, J Adolf-Bryfogle, N Alam, RF Alford, ...
Nature methods 17 (7), 665-680, 2020
302020
Comparative analyses of ubiquitin-like ATG8 and cysteine protease ATG4 autophagy genes in the plant lineage and cross-kingdom processing of ATG8 by ATG4
E Seo, J Woo, E Park, SJ Bertolani, JB Siegel, D Choi, SP Dinesh-Kumar
Autophagy 12 (11), 2054-2068, 2016
302016
Janus: prediction and ranking of mutations required for functional interconversion of enzymes
TA Addington, RW Mertz, JB Siegel, JM Thompson, AJ Fisher, V Filkov, ...
Journal of molecular biology 425 (8), 1378-1389, 2013
302013
Kinetic characterization of 100 glycoside hydrolase mutants enables the discovery of structural features correlated with kinetic constants
DA Carlin, RW Caster, X Wang, SA Betzenderfer, CX Chen, VM Duong, ...
PloS one 11 (1), e0147596, 2016
292016
Mechanistic analysis of an engineered enzyme that catalyzes the formose reaction
S Poust, J Piety, A Bar‐Even, C Louw, D Baker, JD Keasling, JB Siegel
ChemBioChem 16 (13), 1950-1954, 2015
232015
Predicting productive binding modes for substrates and carbocation intermediates in terpene synthases—Bornyl diphosphate synthase as a representative case
TE O’Brien, SJ Bertolani, Y Zhang, JB Siegel, DJ Tantillo
ACS catalysis 8 (4), 3322-3330, 2018
202018
Improvement of a potential anthrax therapeutic by computational protein design
SJ Wu, CB Eiben, JH Carra, I Huang, D Zong, P Liu, CT Wu, J Nivala, ...
Journal of Biological Chemistry 286 (37), 32586-32592, 2011
182011
Engineering a nicotinamide mononucleotide redox cofactor system for biocatalysis
WB Black, L Zhang, WS Mak, S Maxel, Y Cui, E King, B Fong, AS Martinez, ...
Nature chemical biology 16 (1), 87-94, 2020
152020
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