Följ
Sidi Chen, PhD
Sidi Chen, PhD
Yale University (Previous: MIT, Broad Institute, University of Chicago)
Verifierad e-postadress på yale.edu - Startsida
Titel
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CRISPR-Cas9 knockin mice for genome editing and cancer modeling
RJ Platt, S Chen, Y Zhou, MJ Yim, L Swiech, HR Kempton, JE Dahlman, ...
Cell 159 (2), 440-455, 2014
19412014
Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype
H Yin, W Xue, S Chen, RL Bogorad, E Benedetti, M Grompe, ...
Nature biotechnology 32 (6), 551-553, 2014
11952014
Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells
X Wu, DA Scott, AJ Kriz, AC Chiu, PD Hsu, DB Dadon, AW Cheng, ...
Nature biotechnology 32 (7), 670-676, 2014
11352014
Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis
S Chen, NE Sanjana, K Zheng, O Shalem, K Lee, X Shi, DA Scott, J Song, ...
Cell 160 (6), 1246-1260, 2015
10372015
CRISPR-mediated direct mutation of cancer genes in the mouse liver
W Xue, S Chen, H Yin, T Tammela, T Papagiannakopoulos, NS Joshi, ...
Nature 514 (7522), 380-384, 2014
8702014
Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase
K Fan, P Wei, Q Feng, S Chen, C Huang, L Ma, B Lai, J Pei, Y Liu, J Chen, ...
Journal of Biological Chemistry 279 (3), 1637-1642, 2004
3672004
New genes as drivers of phenotypic evolution
S Chen, BH Krinsky, M Long
Nature Reviews Genetics 14 (9), 645-660, 2013
3622013
New genes in Drosophila quickly become essential
S Chen, YE Zhang, M Long
science 330 (6011), 1682-1685, 2010
3022010
High-content CRISPR screening
C Bock, P Datlinger, F Chardon, MA Coelho, MB Dong, KA Lawson, T Lu, ...
Nature Reviews Methods Primers 2 (1), 8, 2022
2682022
New gene evolution: little did we know
M Long, NW VanKuren, S Chen, MD Vibranovski
Annual review of genetics 47, 307-333, 2013
2552013
Systematic immunotherapy target discovery using genome-scale in vivo CRISPR screens in CD8 T cells
MB Dong, G Wang, RD Chow, L Ye, L Zhu, X Dai, JJ Park, HR Kim, ...
Cell 178 (5), 1189-1204. e23, 2019
2222019
AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma
RD Chow, CD Guzman, G Wang, F Schmidt, MW Youngblood, L Ye, ...
Nature neuroscience 20 (10), 1329-1341, 2017
2132017
Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes
NG Ravindra, MM Alfajaro, V Gasque, NC Huston, H Wan, K Szigeti-Buck, ...
PLoS biology 19 (3), e3001143, 2021
1802021
Nonstructural protein 1 of SARS-CoV-2 is a potent pathogenicity factor redirecting host protein synthesis machinery toward viral RNA
S Yuan, L Peng, JJ Park, Y Hu, SC Devarkar, MB Dong, Q Shen, S Wu, ...
Molecular cell 80 (6), 1055-1066. e6, 2020
1562020
In vivo CRISPR screening in CD8 T cells with AAV–Sleeping Beauty hybrid vectors identifies membrane targets for improving immunotherapy for glioblastoma
L Ye, JJ Park, MB Dong, Q Yang, RD Chow, L Peng, Y Du, J Guo, X Dai, ...
Nature biotechnology 37 (11), 1302-1313, 2019
1342019
One-step generation of modular CAR-T cells with AAV–Cpf1
X Dai, JJ Park, Y Du, HR Kim, G Wang, Y Errami, S Chen
Nature methods 16 (3), 247-254, 2019
1322019
Acyl-CoA dehydrogenase drives heat adaptation by sequestering fatty acids
DK Ma, Z Li, AY Lu, F Sun, S Chen, M Rothe, R Menzel, F Sun, HR Horvitz
Cell 161 (5), 1152-1163, 2015
1212015
Global microRNA depletion suppresses tumor angiogenesis
S Chen, Y Xue, X Wu, C Le, A Bhutkar, EL Bell, F Zhang, R Langer, ...
Genes & development 28 (10), 1054-1067, 2014
982014
A web tool for the design of prime-editing guide RNAs
RD Chow, JS Chen, J Shen, S Chen
Nature biomedical engineering 5 (2), 190-194, 2021
972021
Cancer CRISPR screens in vivo
RD Chow, S Chen
Trends in cancer 4 (5), 349-358, 2018
952018
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Artiklar 1–20