| Understanding fibroblast activation protein (FAP): substrates, activities, expression and targeting for cancer therapy EJ Hamson, FM Keane, S Tholen, O Schilling, MD Gorrell PROTEOMICS–Clinical Applications 8 (5-6), 454-463, 2014 | 371 | 2014 |
| Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease D Erny, N Dokalis, C Mezö, A Castoldi, O Mossad, O Staszewski, ... Cell Metabolism 33 (11), 2260-2276. e7, 2021 | 202 | 2021 |
| Fibroblast activation protein-α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterations MM Koczorowska, S Tholen, F Bucher, L Lutz, JN Kizhakkedathu, ... Molecular oncology 10 (1), 40-58, 2016 | 99 | 2016 |
| A transcriptional circuit filters oscillating circadian hormonal inputs to regulate fat cell differentiation Z Bahrami-Nejad, ML Zhao, S Tholen, D Hunerdosse, KE Tkach, ... Cell metabolism 27 (4), 854-868. e8, 2018 | 68 | 2018 |
| Identification of Novel Natural Substrates of Fibroblast Activation Protein-alpha by Differential Degradomics and Proteomics*[S] HE Zhang, EJ Hamson, MM Koczorowska, S Tholen, S Chowdhury, ... Molecular & Cellular Proteomics 18 (1), 65-85, 2019 | 44 | 2019 |
| A High-Frequency Mutation in Bacillus subtilis: Requirements for the Decryptification of the gudB Glutamate Dehydrogenase Gene K Gunka, S Tholen, J Gerwig, C Herzberg, J Stülke, FM Commichau Journal of bacteriology 194 (5), 1036-1044, 2012 | 43 | 2012 |
| Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome S Tholen, ML Biniossek, M Gansz, A Gomez-Auli, F Bengsch, A Noel, ... Molecular & Cellular Proteomics 12 (3), 611-625, 2013 | 42 | 2013 |
| Proteomic identification of protease cleavage sites: cell-biological and biomedical applications H Shahinian, S Tholen, O Schilling Expert review of proteomics 10 (5), 421-433, 2013 | 40 | 2013 |
| Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis S Tholen, ML Biniossek, M Gansz, TD Ahrens, M Schlimpert, ... Cellular and molecular life sciences 71, 899-916, 2014 | 38 | 2014 |
| Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts S Tholen, ML Biniossek, AL Geßler, S Müller, J Weißer, JN Kizhakkedathu, ... Walter de Gruyter 392 (11), 961-971, 2011 | 37 | 2011 |
| The stromal cell-surface protease fibroblast activation protein-α localizes to lipid rafts and is recruited to invadopodia JD Knopf, S Tholen, MM Koczorowska, O De Wever, ML Biniossek, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1853 (10), 2515-2525, 2015 | 28 | 2015 |
| The papain-like cysteine proteinases NbCysP6 and NbCysP7 are highly processive enzymes with substrate specificities complementary to Nicotiana benthamiana cathepsin B M Paireder, S Tholen, A Porodko, ML Biniossek, B Mayer, M Novinec, ... Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1865 (4), 444-452, 2017 | 24 | 2017 |
| The death enzyme CP14 is a unique papain-like cysteine proteinase with a pronounced S2 subsite selectivity M Paireder, U Mehofer, S Tholen, A Porodko, P Schähs, D Maresch, ... Archives of Biochemistry and Biophysics 603, 110-117, 2016 | 22 | 2016 |
| Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo M Tholen, LE Hillebrand, S Tholen, O Sedelmeier, SJ Arnold, ... Nature Communications 5 (1), 4931, 2014 | 19 | 2014 |
| Skin barrier defects caused by keratinocyte-specific deletion of ADAM17 or EGFR are based on highly similar proteome and degradome alterations S Tholen, C Wolf, B Mayer, JD Knopf, S Löffek, Y Qian, ... Journal of Proteome Research 15 (5), 1402-1417, 2016 | 17 | 2016 |
| SPABBATS: A pathway-discovery method based on Boolean satisfiability that facilitates the characterization of suppressor mutants LA Flórez, K Gunka, R Polanía, S Tholen, J Stülke BMC systems biology 5, 1-9, 2011 | 17 | 2011 |
| Proteomics highlights decrease of matricellular proteins in left ventricular assist device therapy JH Shahinian, B Mayer, S Tholen, K Brehm, ML Biniossek, H Füllgraf, ... European Journal of Cardio-Thoracic Surgery 51 (6), 1063-1071, 2017 | 14 | 2017 |
| Impact of left ventricular assist device therapy on the cardiac proteome and metabolome composition in ischemic cardiomyopathy JH Shahinian, EA Rog‐Zielinska, M Schlimpert, B Mayer, S Tholen, ... Artificial Organs 44 (3), 257-267, 2020 | 7 | 2020 |
| Pregnancy specific β-1 glycoprotein 1 is expressed in pancreatic ductal adenocarcinoma and its subcellular localization correlates with overall survival JH Shahinian, H Fuellgraf, S Tholen, J Mastroianni, JD Knopf, M Kuehs, ... Journal of Cancer 7 (14), 2018, 2016 | 7 | 2016 |
| Lipidomic and proteomic alterations induced by even and odd medium-chain fatty acids on fibroblasts of long-chain fatty acid oxidation disorders KI Alatibi, S Tholen, Z Wehbe, J Hagenbuchner, D Karall, ... International Journal of Molecular Sciences 22 (19), 10556, 2021 | 6 | 2021 |
Oliver SchillingUniversity of FreiburgVerified email at mol-med.uni-freiburg.de
