Xuewu Zhang
Xuewu Zhang
Departments of Pharmacology and Biophysics, UT Southwestern Medical Center
Verifierad e-postadress på utsouthwestern.edu - Startsida
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An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
X Zhang, J Gureasko, K Shen, PA Cole, J Kuriyan
Cell 125 (6), 1137-1149, 2006
14532006
Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment
N Jura, NF Endres, K Engel, S Deindl, R Das, MH Lamers, DE Wemmer, ...
Cell 137 (7), 1293-1307, 2009
5222009
Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING
X Zhang, H Shi, J Wu, X Zhang, L Sun, C Chen, ZJ Chen
Molecular cell 51 (2), 226-235, 2013
5012013
Structural and functional analysis of the costimulatory receptor programmed death-1
X Zhang, JCD Schwartz, X Guo, S Bhatia, E Cao, L Chen, ZY Zhang, ...
Immunity 20 (3), 337-347, 2004
3932004
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface
X Zhang, KA Pickin, R Bose, N Jura, PA Cole, J Kuriyan
Nature 450 (7170), 741-744, 2007
3302007
Structural basis for co-stimulation by the human CTLA-4/B7-2 complex
JCD Schwartz, X Zhang, AA Fedorov, SG Nathenson, SC Almo
Nature 410 (6828), 604-608, 2001
3082001
Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization
Y Shan, MP Eastwood, X Zhang, ET Kim, A Arkhipov, RO Dror, J Jumper, ...
Cell 149 (4), 860-870, 2012
2732012
Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms
N Jura, X Zhang, NF Endres, MA Seeliger, T Schindler, J Kuriyan
Molecular cell 42 (1), 9-22, 2011
2682011
The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop
X Zhang, J Wu, F Du, H Xu, L Sun, Z Chen, CA Brautigam, X Zhang, ...
Cell reports 6 (3), 421-430, 2014
1882014
Structural basis for the prion-like MAVS filaments in antiviral innate immunity
H Xu, X He, H Zheng, LJ Huang, F Hou, Z Yu, MJ de la Cruz, B Borkowski, ...
Elife 3, e01489, 2014
1462014
Structural mechanisms of costimulation
JCD Schwartz, X Zhang, SG Nathenson, SC Almo
Nature immunology 3 (5), 427-434, 2002
1382002
Plexins Are GTPase-Activating Proteins for Rap and Are Activated by Induced Dimerization
Y Wang, H He, N Srivastava, S Vikarunnessa, Y Chen, J Jiang, ...
Science's STKE 5 (207), ra6, 2012
1292012
Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling
X Zhang, JCD Schwartz, SC Almo, SG Nathenson
Proceedings of the National Academy of Sciences 100 (5), 2586-2591, 2003
1022003
Structural basis of STING binding with and phosphorylation by TBK1
C Zhang, G Shang, X Gui, X Zhang, X Bai, ZJ Chen
Nature 567 (7748), 394-398, 2019
892019
Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration
H He, T Yang, JR Terman, X Zhang
Proceedings of the National Academy of Sciences 106 (37), 15610-15615, 2009
872009
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP
G Shang, C Zhang, ZJ Chen, X Bai, X Zhang
Nature 567 (7748), 389-393, 2019
812019
The ErbB kinase domain: structural perspectives into kinase activation and inhibition
R Bose, X Zhang
Experimental cell research 315 (4), 649-658, 2009
772009
Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease
MT Falta, C Pinilla, DG Mack, AN Tinega, F Crawford, M Giulianotti, ...
Journal of Experimental Medicine 210 (7), 1403-1418, 2013
592013
Viral pseudo-enzymes activate RIG-I via deamidation to evade cytokine production
S He, J Zhao, S Song, X He, A Minassian, Y Zhou, J Zhang, K Brulois, ...
Molecular cell 58 (1), 134-146, 2015
532015
Structural Analysis and Functional Implications of the Negative mTORC1 Regulator REDD1,
S Vega-Rubin-de-Celis, Z Abdallah, L Kinch, NV Grishin, J Brugarolas, ...
Biochemistry 49 (11), 2491-2501, 2010
532010
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Artiklar 1–20