| Sobol sensitivity analysis: a tool to guide the development and evaluation of systems pharmacology models XY Zhang, MN Trame, LJ Lesko, S Schmidt CPT: pharmacometrics & systems pharmacology 4 (2), 69-79, 2015 | 446 | 2015 |
| Population pharmacokinetics of busulfan in children: increased evidence for body surface area and allometric body weight dosing of busulfan in children MN Trame, M Bergstrand, MO Karlsson, J Boos, G Hempel Clinical Cancer Research 17 (21), 6867-6877, 2011 | 73 | 2011 |
| Population pharmacokinetics of enoxaparin in infants, children and adolescents during secondary thromboembolic prophylaxis: a cohort study MN Trame, L Mitchell, A Krümpel, C Male, G Hempel, U Nowak‐Göttl Journal of Thrombosis and Haemostasis 8 (9), 1950-1958, 2010 | 65 | 2010 |
| Population pharmacokinetics of liposomal amphotericin B and caspofungin in allogeneic hematopoietic stem cell recipients G Würthwein, C Young, C Lanvers-Kaminsky, G Hempel, MN Trame, ... Antimicrobial agents and chemotherapy 56 (1), 536-543, 2012 | 60 | 2012 |
| Population pharmacokinetics of escalating doses of caspofungin in a phase II study of patients with invasive aspergillosis G Würthwein, OA Cornely, MN Trame, JJ Vehreschild, MJGT Vehreschild, ... Antimicrobial agents and chemotherapy 57 (4), 1664-1671, 2013 | 54 | 2013 |
| Nonlinear mixed‐effects model development and simulation using nlmixr and related R open‐source packages M Fidler, JJ Wilkins, R Hooijmaijers, TM Post, R Schoemaker, MN Trame, ... CPT: pharmacometrics & systems pharmacology 8 (9), 621-633, 2019 | 52 | 2019 |
| Evaluation of changes in oral drug absorption in preterm and term neonates for Biopharmaceutics Classification System (BCS) class I and II compounds AA Somani, K Thelen, S Zheng, MN Trame, K Coboeken, M Meyer, ... British Journal of Clinical Pharmacology 81 (1), 137-147, 2016 | 39 | 2016 |
| Systems pharmacology to predict drug safety in drug development MN Trame, K Biliouris, LJ Lesko, JT Mettetal European Journal of Pharmaceutical Sciences 94, 93-95, 2016 | 35 | 2016 |
| Development and validation of a LC–MS/MS assay for quantification of cisplatin in rat plasma and urine AN Shaik, DA Altomare, LJ Lesko, MN Trame Journal of Chromatography B 1046, 243-249, 2017 | 33 | 2017 |
| A semi‐mechanistic population pharmacokinetic model of nusinersen: an antisense oligonucleotide for the treatment of spinal muscular atrophy K Biliouris, P Gaitonde, W Yin, DA Norris, Y Wang, S Henry, R Fey, ... CPT: Pharmacometrics & Systems Pharmacology 7 (9), 581-592, 2018 | 23 | 2018 |
| Improving drug safety with a systems pharmacology approach P Schotland, N Bojunga, A Zien, MN Trame, LJ Lesko European Journal of Pharmaceutical Sciences 94, 84-92, 2016 | 21 | 2016 |
| Physiologically based pharmacokinetic modeling to evaluate formulation factors influencing bioequivalence of metoprolol extended‐release products S Basu, H Yang, L Fang, M Gonzalez‐Sales, L Zhao, MN Trame, L Lesko, ... The Journal of Clinical Pharmacology 59 (9), 1252-1263, 2019 | 20 | 2019 |
| A Comprehensive Review of Novel Drug–Disease Models in Diabetes Drug Development P Gaitonde, P Garhyan, C Link, JY Chien, MN Trame, S Schmidt Clinical pharmacokinetics 55, 769-788, 2016 | 19 | 2016 |
| Quantitative systems pharmacology model to predict the effects of commonly used anticoagulants on the human coagulation network S Hartmann, K Biliouris, LJ Lesko, U Nowak‐Göttl, MN Trame CPT: Pharmacometrics & Systems Pharmacology 5 (10), 554-564, 2016 | 17 | 2016 |
| Quantitative systems pharmacology model-based predictions of clinical endpoints to optimize Warfarin and Rivaroxaban anti-thrombosis therapy S Hartmann, K Biliouris, LJ Lesko, U Nowak-Göttl, MN Trame Frontiers in Pharmacology 11, 520954, 2020 | 13 | 2020 |
| Perspective on the state of pharmacometrics and systems pharmacology integration MN Trame, M Riggs, K Biliouris, D Marathe, J Mettetal, TM Post, ML Rizk, ... CPT: pharmacometrics & systems pharmacology 7 (10), 617-620, 2018 | 13 | 2018 |
| Challenges in alzheimer's disease drug discovery and development: The role of modeling, simulation, and open data DJ Conrado, S Duvvuri, H Geerts, J Burton, C Biesdorf, M Ahamadi, ... Clinical Pharmacology & Therapeutics 107 (4), 796-805, 2020 | 12 | 2020 |
| A pre-clinical quantitative model predicts the pharmacokinetics/pharmacodynamics of an anti-BDCA2 monoclonal antibody in humans K Biliouris, I Nestorov, H Naik, D Dai, G Xiao, Q Wang, A Pellerin, ... Journal of pharmacokinetics and pharmacodynamics 45, 817-827, 2018 | 12 | 2018 |
| Population pharmacokinetics of dimethylacetamide in children during standard and once-daily IV busulfan administration MN Trame, IH Bartelink, J Boos, JJ Boelens, G Hempel Cancer chemotherapy and pharmacology 72, 1149-1155, 2013 | 12 | 2013 |
| nlmixr: Nonlinear mixed effects models in population pharmacokinetics and pharmacodynamics M Fidler, Y Xiong, R Schoemaker, J Wilkins, M Trame, T Post, W Wang R package version 2 (1), 2021 | 11 | 2021 |
