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Jamese Hilliard
Jamese Hilliard
Janssen Pharmceutical R&D
Verified email at its.jnj.com
Title
Cited by
Cited by
Year
A multifunctional bispecific antibody protects against Pseudomonas aeruginosa
A DiGiandomenico, AE Keller, C Gao, GJ Rainey, P Warrener, ...
Science translational medicine 6 (262), 262ra155-262ra155, 2014
2762014
Multiple mechanisms of action for inhibitors of histidine protein kinases from bacterial two-component systems
JJ Hilliard, RM Goldschmidt, L Licata, EZ Baum, K Bush
Antimicrobial agents and chemotherapy 43 (7), 1693-1699, 1999
2221999
Assessment of an anti-alpha-toxin monoclonal antibody for prevention and treatment of Staphylococcus aureus-induced pneumonia
L Hua, JJ Hilliard, Y Shi, C Tkaczyk, LI Cheng, X Yu, V Datta, S Ren, ...
Antimicrobial agents and chemotherapy 58 (2), 1108-1117, 2014
1892014
Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections
TS Cohen, JJ Hilliard, O Jones-Nelson, AE Keller, T O’Day, C Tkaczyk, ...
Science Translational Medicine 8 (329), 329ra31-329ra31, 2016
1142016
Novel inhibitors of bacterial two-component systems with gram positive antibacterial activity: pharmacophore identification based on the screening hit closantel
DJ Hlasta, JP Demers, BD Foleno, SA Fraga-Spano, J Guan, JJ Hilliard, ...
Bioorganic & medicinal chemistry letters 8 (14), 1923-1928, 1998
951998
Staphylococcus aureus alpha toxin suppresses effective innate and adaptive immune responses in a murine dermonecrosis model
C Tkaczyk, MM Hamilton, V Datta, XP Yang, JJ Hilliard, GL Stephens, ...
PLoS One 8 (10), e75103, 2013
942013
MEDI4893* promotes survival and extends the antibiotic treatment window in a Staphylococcus aureus immunocompromised pneumonia model
L Hua, TS Cohen, Y Shi, V Datta, JJ Hilliard, C Tkaczyk, J Suzich, ...
Antimicrobial agents and chemotherapy 59 (8), 4526-4532, 2015
752015
A comparison of active site binding of 4-quinolones and novel flavone gyrase inhibitors to DNA gyrase
JJ Hilliard, HM Krause, JI Bernstein, JA Fernandez, V Nguyen, ...
Antimicrobial Resistance: A Crisis in Health Care, 59-69, 1995
741995
Candida albicans Augments Staphylococcus aureus Virulence by Engaging the Staphylococcal agr Quorum Sensing System
OA Todd, PL Fidel Jr, JM Harro, JJ Hilliard, C Tkaczyk, BR Sellman, ...
MBio 10 (3), 10.1128/mbio. 00910-19, 2019
702019
Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a Staphylococcus aureus dermonecrosis model
JJ Hilliard, V Datta, C Tkaczyk, M Hamilton, A Sadowska, O Jones-Nelson, ...
Antimicrobial agents and chemotherapy 59 (1), 299-309, 2015
642015
Synthesis and topoisomerase inhibitory activities of novel aza-analogues of flavones
Z Sui, VN Nguyen, J Altom, J Fernandez, JJ Hilliard, JI Bernstein, ...
European journal of medicinal chemistry 34 (5), 381-387, 1999
521999
Targeting alpha toxin to mitigate its lethal toxicity in ferret and rabbit models of Staphylococcus aureus necrotizing pneumonia
BA Diep, JJ Hilliard, VTM Le, C Tkaczyk, HN Le, VG Tran, RL Rao, EC Dip, ...
Antimicrobial agents and chemotherapy 61 (4), 10.1128/aac. 02456-16, 2017
422017
Testing potential gyrase inhibitors of bacterial DNA gyrase: a comparison of the supercoiling inhibition assay and" cleavable complex" assay
JF Barrett, JI Bernstein, HM Krause, JJ Hilliard, KA Ohemeng
Analytical biochemistry 214 (1), 313-317, 1993
401993
Critical role of alpha-toxin and protective effects of its neutralization by a human antibody in acute bacterial skin and skin structure infections
VTM Le, C Tkaczyk, S Chau, RL Rao, EC Dip, EP Pereira-Franchi, ...
Antimicrobial agents and chemotherapy 60 (10), 5640-5648, 2016
392016
PinA inhibits ATP hydrolysis and energy-dependent protein degradation by Lon protease
JJ Hilliard, LD Simon, L Van Melderen, MR Maurizi
Journal of Biological Chemistry 273 (1), 524-527, 1998
371998
The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones
MA Weidner-Wells, HM Werblood, R Goldschmidt, K Bush, BD Foleno, ...
Bioorganic & medicinal chemistry letters 14 (12), 3069-3072, 2004
342004
Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes
X Xu, T Henninger, D Abbanat, K Bush, B Foleno, J Hilliard, M Macielag
Bioorganic & medicinal chemistry letters 15 (4), 883-887, 2005
332005
Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics
TC Henninger, X Xu, D Abbanat, EZ Baum, BD Foleno, JJ Hilliard, K Bush, ...
Bioorganic & medicinal chemistry letters 14 (17), 4495-4499, 2004
322004
DNA gyrase inhibitory and antimicrobial activities of some diphenic acid monohydroxamides
KA Ohemeng, BL Podlogar, VN Nguyen, JI Bernstein, HM Krause, ...
Journal of medicinal chemistry 40 (20), 3292-3296, 1997
311997
DNA gyrase inhibitory activity of ellagic acid derivatives
MA Weidner-Wells, J Altom, J Fernandez, SA Fraga-Spano, J Hilliard, ...
Bioorganic & medicinal chemistry letters 8 (1), 97-100, 1998
271998
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