Jamese Hilliard
Jamese Hilliard
Janssen Pharmceutical R&D
Verified email at its.jnj.com
Cited by
Cited by
Multiple mechanisms of action for inhibitors of histidine protein kinases from bacterial two-component systems
JJ Hilliard, RM Goldschmidt, L Licata, EZ Baum, K Bush
Antimicrobial agents and chemotherapy 43 (7), 1693-1699, 1999
A multifunctional bispecific antibody protects against Pseudomonas aeruginosa
A DiGiandomenico, AE Keller, C Gao, GJ Rainey, P Warrener, ...
Science Translational Medicine 6 (262), 262ra155-262ra155, 2014
Assessment of an anti-alpha-toxin monoclonal antibody for prevention and treatment of Staphylococcus aureus-induced pneumonia
L Hua, JJ Hilliard, Y Shi, C Tkaczyk, LI Cheng, X Yu, V Datta, S Ren, ...
Antimicrobial agents and chemotherapy 58 (2), 1108-1117, 2014
Novel inhibitors of bacterial two-component systems with gram positive antibacterial activity: pharmacophore identification based on the screening hit closantel
DJ Hlasta, JP Demers, BD Foleno, SA Fraga-Spano, J Guan, JJ Hilliard, ...
Bioorganic & Medicinal Chemistry Letters 8 (14), 1923-1928, 1998
Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections
TS Cohen, JJ Hilliard, O Jones-Nelson, AE Keller, T O’Day, C Tkaczyk, ...
Science Translational Medicine 8 (329), 329ra31-329ra31, 2016
Staphylococcus aureus alpha toxin suppresses effective innate and adaptive immune responses in a murine dermonecrosis model
C Tkaczyk, MM Hamilton, V Datta, XP Yang, JJ Hilliard, GL Stephens, ...
PLoS One 8 (10), e75103, 2013
A comparison of active site binding of 4-quinolones and novel flavone gyrase inhibitors to DNA gyrase
JJ Hilliard, HM Krause, JI Bernstein, JA Fernandez, V Nguyen, ...
Antimicrobial resistance, 59-69, 1995
MEDI4893* promotes survival and extends the antibiotic treatment window in a Staphylococcus aureus immunocompromised pneumonia model
L Hua, TS Cohen, Y Shi, V Datta, JJ Hilliard, C Tkaczyk, J Suzich, ...
Antimicrobial agents and chemotherapy 59 (8), 4526-4532, 2015
Synthesis and topoisomerase inhibitory activities of novel aza-analogues of flavones
Z Sui, VN Nguyen, J Altom, J Fernandez, JJ Hilliard, JI Bernstein, ...
European journal of medicinal chemistry 34 (5), 381-387, 1999
Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a Staphylococcus aureus dermonecrosis model
JJ Hilliard, V Datta, C Tkaczyk, M Hamilton, A Sadowska, O Jones-Nelson, ...
Antimicrobial agents and chemotherapy 59 (1), 299-309, 2015
Testing potential gyrase inhibitors of bacterial DNA gyrase: a comparison of the supercoiling inhibition assay and" cleavable complex" assay
JF Barrett, JI Bernstein, HM Krause, JJ Hilliard, KA Ohemeng
Analytical biochemistry 214 (1), 313-317, 1993
PinA inhibits ATP hydrolysis and energy-dependent protein degradation by Lon protease
JJ Hilliard, LD Simon, L Van Melderen, MR Maurizi
Journal of Biological Chemistry 273 (1), 524-527, 1998
Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics
TC Henninger, X Xu, D Abbanat, EZ Baum, BD Foleno, JJ Hilliard, K Bush, ...
Bioorganic & medicinal chemistry letters 14 (17), 4495-4499, 2004
The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones
MA Weidner-Wells, HM Werblood, R Goldschmidt, K Bush, BD Foleno, ...
Bioorganic & medicinal chemistry letters 14 (12), 3069-3072, 2004
Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes
X Xu, T Henninger, D Abbanat, K Bush, B Foleno, J Hilliard, M Macielag
Bioorganic & medicinal chemistry letters 15 (4), 883-887, 2005
DNA gyrase inhibitory and antimicrobial activities of some diphenic acid monohydroxamides
KA Ohemeng, BL Podlogar, VN Nguyen, JI Bernstein, HM Krause, ...
Journal of medicinal chemistry 40 (20), 3292-3296, 1997
Targeting alpha toxin to mitigate its lethal toxicity in ferret and rabbit models of Staphylococcus aureus necrotizing pneumonia
BA Diep, JJ Hilliard, VTM Le, C Tkaczyk, HN Le, VG Tran, RL Rao, EC Dip, ...
Antimicrobial agents and chemotherapy 61 (4), 2017
Critical role of alpha-toxin and protective effects of its neutralization by a human antibody in acute bacterial skin and skin structure infections
VTM Le, C Tkaczyk, S Chau, RL Rao, EC Dip, EP Pereira-Franchi, ...
Antimicrobial agents and chemotherapy 60 (10), 5640-5648, 2016
Synthesis and antibacterial activity of 7-(1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-7-yl) quinolones
B Zhu, BA Marinelli, R Goldschmidt, BD Foleno, JJ Hilliard, K Bush, ...
Bioorganic & medicinal chemistry letters 19 (17), 4933-4936, 2009
In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457
JJ Hilliard, J Fernandez, J Melton, MJ Macielag, R Goldschmidt, K Bush, ...
Antimicrobial agents and chemotherapy 53 (5), 2028-2033, 2009
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