A multifunctional bispecific antibody protects against Pseudomonas aeruginosa A DiGiandomenico, AE Keller, C Gao, GJ Rainey, P Warrener, ... Science translational medicine 6 (262), 262ra155-262ra155, 2014 | 276 | 2014 |
Multiple mechanisms of action for inhibitors of histidine protein kinases from bacterial two-component systems JJ Hilliard, RM Goldschmidt, L Licata, EZ Baum, K Bush Antimicrobial agents and chemotherapy 43 (7), 1693-1699, 1999 | 222 | 1999 |
Assessment of an anti-alpha-toxin monoclonal antibody for prevention and treatment of Staphylococcus aureus-induced pneumonia L Hua, JJ Hilliard, Y Shi, C Tkaczyk, LI Cheng, X Yu, V Datta, S Ren, ... Antimicrobial agents and chemotherapy 58 (2), 1108-1117, 2014 | 189 | 2014 |
Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections TS Cohen, JJ Hilliard, O Jones-Nelson, AE Keller, T O’Day, C Tkaczyk, ... Science Translational Medicine 8 (329), 329ra31-329ra31, 2016 | 114 | 2016 |
Novel inhibitors of bacterial two-component systems with gram positive antibacterial activity: pharmacophore identification based on the screening hit closantel DJ Hlasta, JP Demers, BD Foleno, SA Fraga-Spano, J Guan, JJ Hilliard, ... Bioorganic & medicinal chemistry letters 8 (14), 1923-1928, 1998 | 95 | 1998 |
Staphylococcus aureus alpha toxin suppresses effective innate and adaptive immune responses in a murine dermonecrosis model C Tkaczyk, MM Hamilton, V Datta, XP Yang, JJ Hilliard, GL Stephens, ... PLoS One 8 (10), e75103, 2013 | 94 | 2013 |
MEDI4893* promotes survival and extends the antibiotic treatment window in a Staphylococcus aureus immunocompromised pneumonia model L Hua, TS Cohen, Y Shi, V Datta, JJ Hilliard, C Tkaczyk, J Suzich, ... Antimicrobial agents and chemotherapy 59 (8), 4526-4532, 2015 | 75 | 2015 |
A comparison of active site binding of 4-quinolones and novel flavone gyrase inhibitors to DNA gyrase JJ Hilliard, HM Krause, JI Bernstein, JA Fernandez, V Nguyen, ... Antimicrobial Resistance: A Crisis in Health Care, 59-69, 1995 | 74 | 1995 |
Candida albicans Augments Staphylococcus aureus Virulence by Engaging the Staphylococcal agr Quorum Sensing System OA Todd, PL Fidel Jr, JM Harro, JJ Hilliard, C Tkaczyk, BR Sellman, ... MBio 10 (3), 10.1128/mbio. 00910-19, 2019 | 70 | 2019 |
Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a Staphylococcus aureus dermonecrosis model JJ Hilliard, V Datta, C Tkaczyk, M Hamilton, A Sadowska, O Jones-Nelson, ... Antimicrobial agents and chemotherapy 59 (1), 299-309, 2015 | 64 | 2015 |
Synthesis and topoisomerase inhibitory activities of novel aza-analogues of flavones Z Sui, VN Nguyen, J Altom, J Fernandez, JJ Hilliard, JI Bernstein, ... European journal of medicinal chemistry 34 (5), 381-387, 1999 | 52 | 1999 |
Targeting alpha toxin to mitigate its lethal toxicity in ferret and rabbit models of Staphylococcus aureus necrotizing pneumonia BA Diep, JJ Hilliard, VTM Le, C Tkaczyk, HN Le, VG Tran, RL Rao, EC Dip, ... Antimicrobial agents and chemotherapy 61 (4), 10.1128/aac. 02456-16, 2017 | 42 | 2017 |
Testing potential gyrase inhibitors of bacterial DNA gyrase: a comparison of the supercoiling inhibition assay and" cleavable complex" assay JF Barrett, JI Bernstein, HM Krause, JJ Hilliard, KA Ohemeng Analytical biochemistry 214 (1), 313-317, 1993 | 40 | 1993 |
Critical role of alpha-toxin and protective effects of its neutralization by a human antibody in acute bacterial skin and skin structure infections VTM Le, C Tkaczyk, S Chau, RL Rao, EC Dip, EP Pereira-Franchi, ... Antimicrobial agents and chemotherapy 60 (10), 5640-5648, 2016 | 39 | 2016 |
PinA inhibits ATP hydrolysis and energy-dependent protein degradation by Lon protease JJ Hilliard, LD Simon, L Van Melderen, MR Maurizi Journal of Biological Chemistry 273 (1), 524-527, 1998 | 37 | 1998 |
The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones MA Weidner-Wells, HM Werblood, R Goldschmidt, K Bush, BD Foleno, ... Bioorganic & medicinal chemistry letters 14 (12), 3069-3072, 2004 | 34 | 2004 |
Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes X Xu, T Henninger, D Abbanat, K Bush, B Foleno, J Hilliard, M Macielag Bioorganic & medicinal chemistry letters 15 (4), 883-887, 2005 | 33 | 2005 |
Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics TC Henninger, X Xu, D Abbanat, EZ Baum, BD Foleno, JJ Hilliard, K Bush, ... Bioorganic & medicinal chemistry letters 14 (17), 4495-4499, 2004 | 32 | 2004 |
DNA gyrase inhibitory and antimicrobial activities of some diphenic acid monohydroxamides KA Ohemeng, BL Podlogar, VN Nguyen, JI Bernstein, HM Krause, ... Journal of medicinal chemistry 40 (20), 3292-3296, 1997 | 31 | 1997 |
DNA gyrase inhibitory activity of ellagic acid derivatives MA Weidner-Wells, J Altom, J Fernandez, SA Fraga-Spano, J Hilliard, ... Bioorganic & medicinal chemistry letters 8 (1), 97-100, 1998 | 27 | 1998 |