Christian Hurtz
Christian Hurtz
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BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR–ABL1 kinase inhibition
C Duy, C Hurtz, S Shojaee, L Cerchietti, H Geng, S Swaminathan, ...
Nature 473 (7347), 384-388, 2011
BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia
C Hurtz, K Hatzi, L Cerchietti, M Braig, E Park, Y Kim, S Herzog, ...
Journal of Experimental Medicine 208 (11), 2163-2174, 2011
Metabolic gatekeeper function of B-lymphoid transcription factors
LN Chan, Z Chen, D Braas, JW Lee, G Xiao, H Geng, KN Cosgun, C Hurtz, ...
Nature 542 (7642), 479-483, 2017
BCL6 is critical for the development of a diverse primary B cell repertoire
C Duy, JJ Yu, R Nahar, S Swaminathan, SM Kweon, JM Polo, E Valls, ...
Journal of Experimental Medicine 207 (6), 1209-1221, 2010
Erk negative feedback control enables pre-B cell transformation and represents a therapeutic target in acute lymphoblastic leukemia
S Shojaee, R Caeser, M Buchner, E Park, S Swaminathan, C Hurtz, ...
Cancer cell 28 (1), 114-128, 2015
Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia
H Geng, C Hurtz, KB Lenz, Z Chen, D Baumjohann, S Thompson, ...
Cancer cell 27 (3), 409-425, 2015
BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint
S Swaminathan, C Huang, H Geng, Z Chen, R Harvey, H Kang, C Ng, ...
Nature medicine 19 (8), 1014-1022, 2013
Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia
B Kharabi Masouleh, H Geng, C Hurtz, LN Chan, AC Logan, MS Chang, ...
Proceedings of the National Academy of Sciences 111 (21), E2219-E2228, 2014
Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia
H Geng, S Brennan, TA Milne, WY Chen, Y Li, C Hurtz, SM Kweon, L Zickl, ...
Cancer discovery 2 (11), 1004-1023, 2012
High incidence of Philadelphia chromosome-like acute lymphoblastic leukemia in older adults with B-ALL
SK Tasian, C Hurtz, GB Wertheim, NG Bailey, MS Lim, RC Harvey, ...
Leukemia 31 (4), 981-984, 2017
SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia
P Ramezani-Rad, H Geng, C Hurtz, LN Chan, Z Chen, H Jumaa, ...
Blood, The Journal of the American Society of Hematology 121 (1), 148-155, 2013
Ibrutinib inhibits pre-BCR+ B-cell acute lymphoblastic leukemia progression by targeting BTK and BLK
E Kim, C Hurtz, S Koehrer, Z Wang, S Balasubramanian, BY Chang, ...
Blood, The Journal of the American Society of Hematology 129 (9), 1155-1165, 2017
Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures
NA Graham, A Minasyan, A Lomova, A Cass, NG Balanis, M Friedman, ...
Molecular systems biology 13 (2), 914, 2017
Pre-BCR signaling in precursor B-cell acute lymphoblastic leukemia regulates PI3K/AKT, FOXO1 and MYC, and can be targeted by SYK inhibition
S Köhrer, O Havranek, F Seyfried, C Hurtz, GP Coffey, E Kim, ...
Leukemia 30 (6), 1246-1254, 2016
Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease
R Deng, C Hurtz, Q Song, C Yue, G Xiao, H Yu, X Wu, M Muschen, ...
Nature communications 8 (1), 978, 2017
O-acetylated N-acetylneuraminic acid as a novel target for therapy in human pre-B acute lymphoblastic leukemia
R Parameswaran, M Lim, A Arutyunyan, H Abdel-Azim, C Hurtz, K Lau, ...
Journal of Experimental Medicine 210 (4), 805-819, 2013
Signalling input from divergent pathways subverts B cell transformation
LN Chan, MA Murakami, ME Robinson, R Caeser, T Sadras, J Lee, ...
Nature 583 (7818), 845-851, 2020
Activated natural killer cells predict poor clinical prognosis in high-risk B-and T-cell acute lymphoblastic leukemia
C Duault, A Kumar, A Taghi Khani, SJ Lee, L Yang, M Huang, C Hurtz, ...
Blood 138 (16), 1465-1480, 2021
Oncogene-independent BCR-like signaling adaptation confers drug resistance in Ph-like ALL
C Hurtz, GB Wertheim, JP Loftus, D Blumenthal, A Lehman, Y Li, ...
The Journal of clinical investigation 130 (7), 3637-3653, 2020
Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia
C Hurtz, LN Chan, H Geng, E Ballabio, G Xiao, G Deb, H Khoury, ...
Genes & development 33 (17-18), 1265-1279, 2019
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