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Nils Pemberton
Nils Pemberton
Medicinal Chemistry, RIA iMed, AstraZeneca
Verifierad e-postadress på astrazeneca.com
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Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria
JS Pinkner, H Remaut, F Buelens, E Miller, V Åberg, N Pemberton, ...
Proceedings of the National Academy of Sciences 103 (47), 17897-17902, 2006
3652006
Synthesis of 2-alkyl-substituted chromone derivatives using microwave irradiation
M Friden-Saxin, N Pemberton, K da Silva Andersson, C Dyrager, ...
The Journal of Organic Chemistry 74 (7), 2755-2759, 2009
652009
Synthesis of multi ring-fused 2-pyridones via an acyl-ketene imine cyclocondensation
N Pemberton, L Jakobsson, F Almqvist
Organic Letters 8 (5), 935-938, 2006
582006
Microwave-assisted synthesis of highly substituted aminomethylated 2-pyridones
N Pemberton, V Åberg, H Almstedt, A Westermark, F Almqvist
The Journal of organic chemistry 69 (23), 7830-7835, 2004
562004
Synthesis and functionalization of cyclic sulfonimidamides: a novel chiral heterocyclic carboxylic acid bioisostere
N Pemberton, H Graden, E Evertsson, E Bratt, M Lepistö, ...
ACS Medicinal Chemistry Letters 3 (7), 574-578, 2012
552012
A class of highly selective inhibitors bind to an active state of PI3Kγ
G Gangadhara, G Dahl, T Bohnacker, R Rae, J Gunnarsson, S Blaho, ...
Nature chemical biology 15 (4), 348-357, 2019
452019
Discovery of highly isoform selective orally bioavailable phosphoinositide 3-kinase (PI3K)-γ inhibitors
N Pemberton, M Mogemark, S Arlbrandt, P Bold, RJ Cox, C Gardelli, ...
Journal of Medicinal Chemistry 61 (12), 5435-5441, 2018
422018
KHMDS Enhanced SmI2-Mediated Reformatsky Type α-Cyanation
T Ankner, M Friden-Saxin, N Pemberton, T Seifert, M Grøtli, K Luthman, ...
Organic Letters 12 (10), 2210-2213, 2010
422010
Functionalization of bicyclic 2-pyridones targeting pilus biogenesis in uropathogenic Escherichia coli
N Pemberton, JS Pinkner, JM Jones, L Jakobsson, SJ Hultgren, ...
Tetrahedron letters 48 (26), 4543-4546, 2007
312007
NMR studies of interactions between periplasmic chaperones from uropathogenic E. coli and pilicides that interfere with chaperone function and pilus assembly
M Hedenström, H Emtenäs, N Pemberton, V Åberg, SJ Hultgren, ...
Organic & biomolecular chemistry 3 (23), 4193-4200, 2005
292005
Synthesis and evaluation of dihydroimidazolo and dihydrooxazolo ring-fused 2-pyridones—targeting pilus biogenesis in uropathogenic bacteria
N Pemberton, JS Pinkner, S Edvinsson, SJ Hultgren, F Almqvist
Tetrahedron 64 (40), 9368-9376, 2008
272008
Cycloaddition of Δ2-Thiazolines and Acyl Ketenes under Acidic Conditions Results in Bicyclic 1,3-Oxazinones and Not 6-Acylpenams as Earlier Reported
N Pemberton, H Emtenäs, D Boström, PJ Domaille, WA Greenberg, ...
Organic Letters 7 (6), 1019-1021, 2005
272005
Design and synthesis of soluble and cell-permeable PI3Kδ inhibitors for long-acting inhaled administration
MWD Perry, K Björhall, B Bonn, J Carlsson, Y Chen, A Eriksson, ...
Journal of Medicinal Chemistry 60 (12), 5057-5071, 2017
242017
Discovery of AZD8154, a dual PI3Kγδ inhibitor for the treatment of asthma
MWD Perry, K Bjorhall, P Bold, M Brulls, U Borjesson, J Carlsson, ...
Journal of Medicinal Chemistry 64 (12), 8053-8075, 2021
232021
Recent Advances in the Synthesis of β-Ketonitriles
K Kiyokawa, T Nagata, S Minakata
Synthesis 50 (03), 485-498, 2018
162018
Chroman-4-one and chromone based somatostatin β-turn mimetics
M Friden-Saxin, T Seifert, M Malo, K da Silva Andersson, N Pemberton, ...
European Journal of Medicinal Chemistry 114, 59-64, 2016
162016
Application of the Intramolecular Diels–Alder Vinylarenе (IMDAV) Approach for the Synthesis of Thieno [2, 3-f] isoindoles
MA Nadirova, YOV Laba, VP Zaytsev, JS Sokolova, KM Pokazeev, ...
Synthesis 52 (15), 2196-2223, 2020
122020
Enantiomeric purity determination by NMR: proving the purity of a single enantiomer
RJ Lewis, MA Bernstein, HF Chang, D Chapman, N Pemberton
Tetrahedron: Asymmetry 24 (13-14), 866-870, 2013
112013
MeONH2· HCl-Mediated α-Methylenation/Conjugate Addition of α-Sulfonyl o-Hydroxyacetophenones with Methyl Sulfoxides: Route to 3-Sulfonylchroman-4-ones
MY Chang, KT Chen
Synthesis 53 (01), 135-145, 2021
92021
Microwave-assisted synthesis and functionalization of 2-pyridones, 2-quinolones and other ring-fused 2-pyridones
N Pemberton, E Chorell, F Almqvist
Microwave-Assisted Synthesis of Heterocycles, 1-30, 2006
92006
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Artiklar 1–20