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Elisa Passini
Elisa Passini
National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs)
Verifierad e-postadress på nc3rs.org.uk - Startsida
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Human in silico drug trials demonstrate higher accuracy than animal models in predicting clinical pro-arrhythmic cardiotoxicity
E Passini, OJ Britton, HR Lu, J Rohrbacher, AN Hermans, DJ Gallacher, ...
Frontiers in physiology, 668, 2017
2092017
Variability in cardiac electrophysiology: using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm
A Muszkiewicz, OJ Britton, P Gemmell, E Passini, C Sánchez, X Zhou, ...
Progress in biophysics and molecular biology 120 (1-3), 115-127, 2016
1492016
Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy
E Passini, A Mincholé, R Coppini, E Cerbai, B Rodriguez, S Severi, ...
Journal of molecular and cellular cardiology 96, 72-81, 2016
1012016
Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block
J Tomek, A Bueno-Orovio, E Passini, X Zhou, A Minchole, O Britton, ...
Elife 8, 2019
902019
General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy
Z Li, GR Mirams, T Yoshinaga, BJ Ridder, X Han, JE Chen, ...
Clinical Pharmacology & Therapeutics 107 (1), 102-111, 2020
572020
Phenotypic variability in LQT3 human induced pluripotent stem cell-derived cardiomyocytes and their response to antiarrhythmic pharmacologic therapy: an in silico approach
M Paci, E Passini, S Severi, J Hyttinen, B Rodriguez
Heart Rhythm 14 (11), 1704-1712, 2017
492017
Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop
B Rodriguez, A Carusi, N Abi-Gerges, R Ariga, O Britton, G Bub, ...
Ep Europace 18 (9), 1287-1298, 2015
482015
Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior
V András, J Tomek, N Nagy, L Virág, E Passini, B Rodriguez, I Baczkó
Physiological reviews, 2021
442021
Drug‐induced shortening of the electromechanical window is an effective biomarker for in silico prediction of clinical risk of arrhythmias
E Passini, C Trovato, P Morissette, F Sannajust, A Bueno‐Orovio, ...
British journal of pharmacology 176 (19), 3819-3833, 2019
392019
Recurrent intradialytic paroxysmal atrial fibrillation: hypotheses on onset mechanisms based on clinical data and computational analysis
A Vincenti, E Passini, P Fabbrini, MC Luise, S Severi, S Genovesi
Europace 16 (3), 396-404, 2014
382014
All-optical electrophysiology refines populations of in silico human iPSC-CMs for drug evaluation
M Paci, E Passini, A Klimas, S Severi, J Hyttinen, B Rodriguez, ...
Biophysical journal 118 (10), 2596-2611, 2020
332020
Human Purkinje in silico model enables mechanistic investigations into automaticity and pro-arrhythmic abnormalities
C Trovato, E Passini, N Nagy, A Varró, N Abi-Gerges, S Severi, ...
Journal of molecular and cellular cardiology 142, 24-38, 2020
302020
Blinded in silico drug trial reveals the minimum set of ion channels for torsades de pointes risk assessment
X Zhou, Y Qu, E Passini, A Bueno-Orovio, Y Liu, HM Vargas, B Rodriguez
Frontiers in pharmacology, 1643, 2020
222020
Simulation of the effects of extracellular calcium changes leads to a novel computational model of human ventricular action potential with a revised calcium handling
C Bartolucci, E Passini, J Hyttinen, M Paci, S Severi
Frontiers in physiology 11, 314, 2020
202020
Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19
A Delaunois, M Abernathy, WD Anderson, KA Beattie, KW Chaudhary, ...
Clinical and Translational Science 14 (3), 1133-1146, 2021
122021
A population of in silico models to face the variability of human induced pluripotent stem cell-derived cardiomyocytes: the hERG block case study
M Paci, E Passini, S Severi, J Hyttinen, B Rodriguez
2016 Computing in Cardiology Conference (CinC), 1189-1192, 2016
102016
Comparison of the Simulated Response of Three in Silico Human Stem Cell-Derived Cardiomyocytes Models and in Vitro Data Under 15 Drug Actions
M Paci, JT Koivumäki, HR Lu, DJ Gallacher, E Passini, B Rodriguez
Frontiers in pharmacology 12, 604713, 2021
82021
The virtual assay software for human in silico drug trials to augment drug cardiac testing
E Passini, X Zhou, C Trovato, OJ Britton, A Bueno-Orovio, B Rodriguez
Journal of Computational Science 52, 101202, 2021
72021
Human atrial cell models to analyse haemodialysis-related effects on cardiac electrophysiology: work in progress
E Passini, S Genovesi, S Severi
Computational and Mathematical Methods in Medicine 2014, 2014
72014
In silico populations optimized on optogenetic recordings predict drug effects in human induced pluripotent stem cell-derived cardiomyocytes
M Paci, E Passini, A Klimas, S Severi, J Hyttinen, B Rodriguez, ...
2018 Computing in Cardiology Conference (CinC) 45, 1-4, 2018
62018
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