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Christopher N Toepfer
Christopher N Toepfer
Sir Henry Dale Fellow, Associate Professor, University of Oxford
Verifierad e-postadress på cardiov.ox.ac.uk - Startsida
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Genetic variants associated with cancer therapy–induced cardiomyopathy
P Garcia-Pavia, Y Kim, MA Restrepo-Cordoba, IG Lunde, H Wakimoto, ...
Circulation 140 (1), 31-41, 2019
2362019
Myosin sequestration regulates sarcomere function, cardiomyocyte energetics, and metabolism, informing the pathogenesis of hypertrophic cardiomyopathy
CN Toepfer, AC Garfinkel, G Venturini, H Wakimoto, G Repetti, L Alamo, ...
Circulation 141 (10), 828-842, 2020
2212020
Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin
CN Toepfer, H Wakimoto, AC Garfinkel, B McDonough, D Liao, J Jiang, ...
Science translational medicine 11 (476), eaat1199, 2019
1692019
SarcTrack: an adaptable software tool for efficient large-scale analysis of sarcomere function in hiPSC-cardiomyocytes
CN Toepfer, A Sharma, M Cicconet, AC Garfinkel, M Mücke, M Neyazi, ...
Circulation research 124 (8), 1172-1183, 2019
992019
Myosin regulatory light chain (RLC) phosphorylation change as a modulator of cardiac muscle contraction in disease
C Toepfer, V Caorsi, T Kampourakis, MB Sikkel, T West, JC Leung, ...
Biophysical Journal 104 (2), 309a-310a, 2013
822013
CRISPR/Cas9‐mediated fluorescent tagging of endogenous proteins in human pluripotent stem cells
A Sharma, CN Toepfer, T Ward, L Wasson, R Agarwal, DA Conner, JH Hu, ...
Current protocols in human genetics 96 (1), 21.11. 1-21.11. 20, 2018
772018
Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor
Y Guo, BD Jardin, P Zhou, I Sethi, BN Akerberg, CN Toepfer, Y Ai, Y Li, ...
Nature communications 9 (1), 3837, 2018
732018
Cardiac myosin super relaxation (SRX): a perspective on fundamental biology, human disease and therapeutics
M Schmid, CN Toepfer
Biology open 10 (2), bio057646, 2021
622021
Novel therapies for prevention and early treatment of cardiomyopathies: now and in the future
GG Repetti, CN Toepfer, JG Seidman, CE Seidman
Circulation research 124 (11), 1536-1550, 2019
592019
GATA6 mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm
A Sharma, LK Wasson, JAL Willcox, SU Morton, JM Gorham, ...
Elife 9, e53278, 2020
412020
CalTrack: high-throughput automated calcium transient analysis in cardiomyocytes
Y Psaras, F Margara, M Cicconet, AJ Sparrow, GG Repetti, M Schmid, ...
Circulation research 129 (2), 326-341, 2021
402021
Differentiation and contractile analysis of GFP‐sarcomere reporter hiPSC‐cardiomyocytes
A Sharma, CN Toepfer, M Schmid, AC Garfinkel, CE Seidman
Current protocols in human genetics 96 (1), 21.12. 1-21.12. 12, 2018
402018
Filamin C cardiomyopathy variants cause protein and lysosome accumulation
R Agarwal, JA Paulo, CN Toepfer, JK Ewoldt, S Sundaram, A Chopra, ...
Circulation research 129 (7), 751-766, 2021
362021
Non-linear optical microscopy sheds light on cardiovascular disease
V Caorsi, C Toepfer, MB Sikkel, AR Lyon, K MacLeod, MA Ferenczi
PLoS One 8 (2), e56136, 2013
342013
Power output of skinned skeletal muscle fibres from the cheetah (Acinonyx jubatus)
TG West, CN Toepfer, RC Woledge, NA Curtin, A Rowlerson, ...
Journal of Experimental Biology 216 (15), 2974-2982, 2013
282013
Genetic Studies of Hypertrophic Cardiomyopathy in Singaporeans Identify Variants in TNNI3 and TNNT2 That Are Common in Chinese Patients
CJ Pua, N Tham, CWL Chin, R Walsh, CC Khor, CN Toepfer, GG Repetti, ...
Circulation: Genomic and Precision Medicine 13 (5), 424-434, 2020
242020
Revisiting Frank–Starling: regulatory light chain phosphorylation alters the rate of force redevelopment (ktr) in a length‐dependent fashion
CN Toepfer, TG West, MA Ferenczi
The Journal of Physiology 594 (18), 5237-5254, 2016
242016
Mechanism based therapies enable personalised treatment of hypertrophic cardiomyopathy
F Margara, Y Psaras, ZJ Wang, M Schmid, R Doste, AC Garfinkel, ...
Scientific reports 12 (1), 22501, 2022
152022
Cardiomyocyte infection by Trypanosoma cruzi promotes innate immune response and glycolysis activation
G Venturini, JM Alvim, K Padilha, CN Toepfer, JM Gorham, LK Wasson, ...
Frontiers in cellular and infection microbiology 13, 1098457, 2023
132023
Pathogenesis of Cardiomyopathy Caused by Variants in ALPK3, an Essential Pseudokinase in the Cardiomyocyte Nucleus and Sarcomere
R Agarwal, H Wakimoto, JA Paulo, Q Zhang, D Reichart, C Toepfer, ...
Circulation 146 (22), 1674-1693, 2022
122022
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