The cellular prion protein binds copper in vivo DR Brown, K Qin, JW Herms, A Madlung, J Manson, R Strome, PE Fraser, ... Nature 390 (6661), 684, 1997 | 1678 | 1997 |
Normal prion protein has an activity like that of superoxide dismutase DR Brown, W Boon-Seng, F Hafiz, C Clive, SJ HASWELL, IM JONES Biochemical Journal 344 (1), 1-5, 1999 | 726 | 1999 |
Role of microglia and host prion protein in neurotoxicity of a prion protein fragment DR Brown, B Schmidt, HA Kretzschmar Nature 380 (6572), 345, 1996 | 637 | 1996 |
Prion protein-deficient cells show altered response to oxidative stress due to decreased SOD-1 activity DR Brown, WJ Schulz-Schaeffer, B Schmidt, HA Kretzschmar Experimental neurology 146 (1), 104-112, 1997 | 609 | 1997 |
Prion protein expression and superoxide dismutase activity DR BROWN, A Besinger Biochemical Journal 334 (2), 423-429, 1998 | 371 | 1998 |
Consequences of manganese replacement of copper for prion protein function and proteinase resistance DR Brown, F Hafiz, LL Glasssmith, BS Wong, IM Jones, C Clive, ... The EMBO journal 19 (6), 1180-1186, 2000 | 331 | 2000 |
Antioxidant activity related to copper binding of native prion protein DR Brown, C Clive, SJ Haswell Journal of neurochemistry 76 (1), 69-76, 2001 | 303 | 2001 |
Role of microglia in neuronal cell death in prion disease A Giese, DR Brown, MH Groschup, C Feldmann, I Haist, HA Kretzschmar Brain Pathology 8 (3), 449-457, 1998 | 298 | 1998 |
Lack of prion protein expression results in a neuronal phenotype sensitive to stress DR Brown, RSJ Nicholas, L Canevari Journal of neuroscience research 67 (2), 211-224, 2002 | 294 | 2002 |
Preferential Cu2+ coordination by His96 and His111 induces β-sheet formation in the unstructured amyloidogenic region of the prion protein CE Jones, SR Abdelraheim, DR Brown, JH Viles Journal of Biological Chemistry 279 (31), 32018-32027, 2004 | 290 | 2004 |
Prion and prejudice: normal protein and the synapse DR Brown Trends in neurosciences 24 (2), 85-90, 2001 | 278 | 2001 |
Biological inorganic and bioinorganic chemistry of neurodegeneration based on prion and Alzheimer diseases DR Brown, H Kozlowski Dalton Transactions, 1907-1917, 2004 | 274 | 2004 |
Mouse cortical cells lacking cellular PrP survive in culture with a neurotoxic PrP fragment. DR Brown, J Herms, HA Kretzschmar Neuroreport 5 (16), 2057-2060, 1994 | 260 | 1994 |
Immunization delays the onset of prion disease in mice EM Sigurdsson, DR Brown, M Daniels, RJ Kascsak, R Kascsak, R Carp, ... The American journal of pathology 161 (1), 13-17, 2002 | 249 | 2002 |
Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein BS Wong, T Liu, R Li, T Pan, RB Petersen, MA Smith, P Gambetti, G Perry, ... Journal of neurochemistry 76 (2), 565-572, 2001 | 244 | 2001 |
Copper chelation delays the onset of prion disease EM Sigurdsson, DR Brown, MA Alim, H Scholtzova, R Carp, HC Meeker, ... Journal of Biological Chemistry 278 (47), 46199-46202, 2003 | 243 | 2003 |
Aberrant metal binding by prion protein in human prion disease BS Wong, SG Chen, M Colucci, Z Xie, T Pan, T Liu, R Li, P Gambetti, ... Journal of neurochemistry 78 (6), 1400-1408, 2001 | 243 | 2001 |
Seeking a mechanism for the toxicity of oligomeric α-synuclein H Roberts, D Brown Biomolecules 5 (2), 282-305, 2015 | 241 | 2015 |
Metal imbalance and compromised antioxidant function are early changes in prion disease AM Thackray, R Knight, SJ Haswell, R Bujdoso, DR Brown Biochemical Journal 362 (2), 253-258, 2002 | 238 | 2002 |
Alpha-synuclein is a cellular ferrireductase P Davies, D Moualla, DR Brown PloS one 6 (1), e15814, 2011 | 228 | 2011 |