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Miika Mehine
Miika Mehine
Verifierad e-postadress på helsinki.fi
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MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas
N Mäkinen, M Mehine, J Tolvanen, E Kaasinen, Y Li, HJ Lehtonen, ...
Science 334 (6053), 252-255, 2011
7302011
Characterization of uterine leiomyomas by whole-genome sequencing
M Mehine, E Kaasinen, N Mäkinen, R Katainen, K Kämpjärvi, E Pitkänen, ...
New England Journal of Medicine 369 (1), 43-53, 2013
3462013
Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers
M Mehine, E Kaasinen, HR Heinonen, N Mäkinen, K Kämpjärvi, ...
Proceedings of the National Academy of Sciences 113 (5), 1315-1320, 2016
2082016
Genomics of uterine leiomyomas: insights from high-throughput sequencing
M Mehine, N Mäkinen, HR Heinonen, LA Aaltonen, P Vahteristo
Fertility and sterility 102 (3), 621-629, 2014
1982014
Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer
K Kämpjärvi, N Mäkinen, O Kilpivaara, J Arola, HR Heinonen, J Böhm, ...
British journal of cancer 107 (10), 1761-1765, 2012
1252012
AIP inactivation leads to pituitary tumorigenesis through defective Gαi-cAMP signaling
I Tuominen, E Heliövaara, A Raitila, MR Rautiainen, M Mehine, ...
Oncogene 34 (9), 1174-1184, 2015
1152015
Mutations in Exon 1 Highlight the Role of MED12 in Uterine Leiomyomas
K Kämpjärvi, MJ Park, M Mehine, NH Kim, AD Clark, R Bützow, T Böhling, ...
Human mutation 35 (9), 1136-1141, 2014
892014
Deficient H2A. Z deposition is associated with genesis of uterine leiomyoma
DG Berta, H Kuisma, N Välimäki, M Räisänen, M Jäntti, A Pasanen, ...
Nature 596 (7872), 398-403, 2021
582021
MED12 mutations and FH inactivation are mutually exclusive in uterine leiomyomas
K Kämpjärvi, N Mäkinen, M Mehine, S Välipakka, O Uimari, E Pitkänen, ...
British journal of cancer 114 (12), 1405-1411, 2016
542016
Global metabolomic profiling of uterine leiomyomas
HR Heinonen, M Mehine, N Mäkinen, A Pasanen, E Pitkänen, A Karhu, ...
British journal of cancer 117 (12), 1855-1864, 2017
402017
Germline-focused analysis of tumour-detected variants in 49,264 cancer patients: ESMO Precision Medicine Working Group recommendations
Z Kuzbari, C Bandlamudi, C Loveday, A Garrett, M Mehine, A George, ...
Annals of Oncology 34 (3), 215-227, 2023
322023
Clonally related uterine leiomyomas are common and display branched tumor evolution
M Mehine, HR Heinonen, N Sarvilinna, E Pitkänen, N Mäkinen, ...
Human molecular genetics 24 (15), 4407-4416, 2015
302015
Origin of uterine fibroids: conversion of myometrial stem cells to tumor-initiating cells
H Elkafas, Y Qiwei, A Al-Hendy
Seminars in reproductive medicine 35 (06), 481-486, 2017
282017
Genetic ancestry correlates with somatic differences in a real-world clinical cancer sequencing cohort
K Arora, TN Tran, Y Kemel, M Mehine, YL Liu, S Nandakumar, SA Smith, ...
Cancer discovery 12 (11), 2552-2565, 2022
272022
Chromothripsis in uterine leiomyomas.
DN Markowski, J Bullerdiek
The New England journal of medicine 369 (22), 2160-2160, 2013
192013
MIPUP: minimum perfect unmixed phylogenies for multi-sampled tumors via branchings and ILP
E Husić, X Li, A Hujdurović, M Mehine, R Rizzi, V Mäkinen, M Milanič, ...
Bioinformatics 35 (5), 769-777, 2019
152019
3′ RNA sequencing accurately classifies formalin-fixed paraffin-embedded uterine leiomyomas
M Mehine, S Khamaiseh, T Ahvenainen, T Heikkinen, A Äyräväinen, ...
Cancers 12 (12), 3839, 2020
112020
NBN Pathogenic Germline Variants are Associated with Pan-Cancer Susceptibility and In Vitro DNA Damage Response Defects
S Belhadj, A Khurram, C Bandlamudi, G Palou-Márquez, V Ravichandran, ...
Clinical Cancer Research 29 (2), 422-431, 2023
82023
Expanded genetic testing of GIST patients identifies high proportion of non-syndromic patients with germline alterations
D Mandelker, A Marra, N Mehta, P Selenica, Z Yelskaya, C Yang, J Somar, ...
NPJ Precision Oncology 7 (1), 1, 2023
72023
A novel uterine leiomyoma subtype exhibits NRF2 activation and mutations in genes associated with neddylation of the Cullin 3-RING E3 ligase
M Mehine, T Ahvenainen, S Khamaiseh, J Härkönen, S Reinikka, ...
Oncogenesis 11 (1), 52, 2022
62022
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