| The art of building multifunctional metal-binding agents from basic molecular scaffolds for the potential application in neurodegenerative diseases C Rodríguez-Rodríguez, M Telpoukhovskaia, C Orvig Coordination Chemistry Reviews 256 (19-20), 2308-2332, 2012 | 151 | 2012 |
| Werner coordination chemistry and neurodegeneration MA Telpoukhovskaia, C Orvig Chemical Society Reviews 42 (4), 1836-1846, 2013 | 101 | 2013 |
| N-Aryl-substituted 3-(β-D-glucopyranosyloxy)-2-methyl-4 (1H)-pyridinones as agents for Alzheimer's therapy LE Scott, M Telpoukhovskaia, C Rodríguez-Rodríguez, M Merkel, ... Chemical Science 2 (4), 642-648, 2011 | 76 | 2011 |
| Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis ME Ward, R Chen, HY Huang, C Ludwig, M Telpoukhovskaia, A Taubes, ... Science translational medicine 9 (385), 2017 | 71 | 2017 |
| Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix [4] arene scaffold LK Tsou, GE Dutschman, EA Gullen, M Telpoukhovskaia, YC Cheng, ... Bioorganic & medicinal chemistry letters 20 (7), 2137-2139, 2010 | 63 | 2010 |
| Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases C Wang, MA Telpoukhovskaia, BA Bahr, X Chen, L Gan Current Opinion in Neurobiology 48, 52-58, 2018 | 48 | 2018 |
| Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy FA Sayed, M Telpoukhovskaia, L Kodama, Y Li, Y Zhou, D Le, A Hauduc, ... Proceedings of the National Academy of Sciences 115 (40), 10172-10177, 2018 | 34 | 2018 |
| Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain L Zhan, G Krabbe, F Du, I Jones, MC Reichert, M Telpoukhovskaia, ... PLoS biology 17 (2), e3000134, 2019 | 32 | 2019 |
| Exploring the multifunctionality of thioflavin-and deferiprone-based molecules as acetylcholinesterase inhibitors for potential application in Alzheimer's disease MA Telpoukhovskaia, BO Patrick, C Rodríguez-Rodríguez, C Orvig Molecular BioSystems 9 (4), 792-805, 2013 | 22 | 2013 |
| 3-Hydroxy-4-pyridinone derivatives as metal ion and amyloid binding agents MA Telpoukhovskaia, C Rodríguez-Rodríguez, JF Cawthray, LE Scott, ... Metallomics 6 (2), 249-262, 2014 | 17 | 2014 |
| 3-Hydroxy-4-pyridinone derivatives designed for fluorescence studies to determine interaction with amyloid protein as well as cell permeability MA Telpoukhovskaia, JF Cawthray, C Rodríguez-Rodríguez, LE Scott, ... Bioorganic & Medicinal Chemistry Letters 25 (17), 3654-3657, 2015 | 16 | 2015 |
| Thioflavin-based molecular probes for application in Alzheimer's disease: from in silico to in vitro models C Rodríguez-Rodríguez, MA Telpoukhovskaia, J Alí-Torres, ... Metallomics 7 (1), 83-92, 2015 | 13 | 2015 |
| Synthesis, characterization, and cytotoxicity studies of Cu (II), Zn (II), and Fe (III) complexes of< i> N-</i> derivatized 3-hydroxy-4-pyridiones MA Telpoukhovskaia, C Rodríguez-Rodríguez, LE Scott, BDG Page, ... Journal of Inorganic Biochemistry 132, 59-66, 2014 | 13 | 2014 |
| In silico to in vitro screening of hydroxypyridinones as acetylcholinesterase inhibitors MA Telpoukhovskaia, BO Patrick, C Rodríguez-Rodríguez, C Orvig Bioorganic & Medicinal Chemistry Letters 26 (6), 1624-1628, 2016 | 11 | 2016 |
| Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia MA Telpoukhovskaia, K Liu, FA Sayed, JI Etchegaray, M Xie, L Zhan, Y Li, ... Scientific Reports 10 (1), 1-12, 2020 | | 2020 |
| Single nuclear RNA sequencing reveals microglia diversity associated with cognitive resilience in the AD-BXD mouse model of human Alzheimer’s disease SE Heuer, J Zhang, M Samuels, N Hadad, M Telpoukhovskaia, ... 2020 Alzheimer's Association International Conference, 2020 | | 2020 |
| Brain-wide spatial analysis to identify region-specific changes in cell composition associated with resilience to Alzheimer’s Disease in the AD-BXD mouse population B Gurdon, N Hadad, M Telpoukhovskaia, S Yates, MA Puchades, ... 2020 Alzheimer's Association International Conference, 2020 | | 2020 |
| AD-linked R47H-TREM2 mutation induces disease-enhancing proinflammatory microglial states in mice and humans FA Sayed, L Kodama, JC Udeochu, L Fan, GK Carling, D Le, Q Li, L Zhou, ... bioRxiv, 2020 | | 2020 |
| AD-Linked TREM2 Mutation Induces Unique Microglial States Associated with Toxic Function in Tauopathy FA Sayed, L Kodama, J Udeochu, H Mathys, D Le, X Niu, L Mazutis, ... | | 2019 |
| Identifying compounds that restore normal cellular function in Frontotemporal dementia caused by progranulin haploinsufficiency M Telpoukhovskaia, K Liu, F Sayed, JI Etchegaray, Y Zhou, D Le, M Xie, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 256, 2018 | | 2018 |
Chris OrvigProfessor of Chemistry and Pharmaceutical SciencesVerified email at chem.ubc.ca
