Maria A. Telpoukhovskaia
Maria A. Telpoukhovskaia
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The art of building multifunctional metal-binding agents from basic molecular scaffolds for the potential application in neurodegenerative diseases
C Rodríguez-Rodríguez, M Telpoukhovskaia, C Orvig
Coordination Chemistry Reviews 256 (19-20), 2308-2332, 2012
Werner coordination chemistry and neurodegeneration
MA Telpoukhovskaia, C Orvig
Chemical Society Reviews 42 (4), 1836-1846, 2013
Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis
ME Ward, R Chen, HY Huang, C Ludwig, M Telpoukhovskaia, A Taubes, ...
Science translational medicine 9 (385), 2017
N-Aryl-substituted 3-(β-D-glucopyranosyloxy)-2-methyl-4 (1H)-pyridinones as agents for Alzheimer's therapy
LE Scott, M Telpoukhovskaia, C Rodríguez-Rodríguez, M Merkel, ...
Chemical Science 2 (4), 642-648, 2011
Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix [4] arene scaffold
LK Tsou, GE Dutschman, EA Gullen, M Telpoukhovskaia, YC Cheng, ...
Bioorganic & medicinal chemistry letters 20 (7), 2137-2139, 2010
Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases
C Wang, MA Telpoukhovskaia, BA Bahr, X Chen, L Gan
Current Opinion in Neurobiology 48, 52-58, 2018
Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain
L Zhan, G Krabbe, F Du, I Jones, MC Reichert, M Telpoukhovskaia, ...
PLoS biology 17 (2), e3000134, 2019
Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy
FA Sayed, M Telpoukhovskaia, L Kodama, Y Li, Y Zhou, D Le, A Hauduc, ...
Proceedings of the National Academy of Sciences 115 (40), 10172-10177, 2018
Exploring the multifunctionality of thioflavin-and deferiprone-based molecules as acetylcholinesterase inhibitors for potential application in Alzheimer's disease
MA Telpoukhovskaia, BO Patrick, C Rodríguez-Rodríguez, C Orvig
Molecular BioSystems 9 (4), 792-805, 2013
3-Hydroxy-4-pyridinone derivatives as metal ion and amyloid binding agents
MA Telpoukhovskaia, C Rodríguez-Rodríguez, JF Cawthray, LE Scott, ...
Metallomics 6 (2), 249-262, 2014
In silico to in vitro screening of hydroxypyridinones as acetylcholinesterase inhibitors
MA Telpoukhovskaia, BO Patrick, C Rodríguez-Rodríguez, C Orvig
Bioorganic & Medicinal Chemistry Letters 26 (6), 1624-1628, 2016
Thioflavin-based molecular probes for application in Alzheimer's disease: from in silico to in vitro models
C Rodríguez-Rodríguez, MA Telpoukhovskaia, J Alí-Torres, ...
Metallomics 7 (1), 83-92, 2015
3-Hydroxy-4-pyridinone derivatives designed for fluorescence studies to determine interaction with amyloid protein as well as cell permeability
MA Telpoukhovskaia, JF Cawthray, C Rodríguez-Rodríguez, LE Scott, ...
Bioorganic & Medicinal Chemistry Letters 25 (17), 3654-3657, 2015
Synthesis, characterization, and cytotoxicity studies of Cu (II), Zn (II), and Fe (III) complexes of< i> N-</i> derivatized 3-hydroxy-4-pyridiones
MA Telpoukhovskaia, C Rodríguez-Rodríguez, LE Scott, BDG Page, ...
Journal of Inorganic Biochemistry 132, 59-66, 2014
Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia
MA Telpoukhovskaia, K Liu, FA Sayed, JI Etchegaray, M Xie, L Zhan, Y Li, ...
Scientific Reports 10 (1), 1-12, 2020
AD-linked R47H-TREM2 mutation induces disease-enhancing proinflammatory microglial states in mice and humans
FA Sayed, L Kodama, JC Udeochu, L Fan, GK Carling, D Le, Q Li, L Zhou, ...
bioRxiv, 2020
Single nuclear RNA sequencing reveals microglia diversity associated with cognitive resilience in the AD‐BXD mouse model of human Alzheimer’s disease: Molecular and cell …
SE Heuer, J Zhang, M Samuels, N Hadad, M Telpoukhovskaia, ...
Alzheimer's & Dementia 16, e041543, 2020
Brain‐wide spatial analysis to identify region‐specific changes in cell composition associated with resilience to Alzheimer’s disease in the AD‐BXD mouse population: Developing …
B Gurdon, N Hadad, M Telpoukhovskaia, S Yates, MA Puchades, ...
Alzheimer's & Dementia 16, e047613, 2020
Single nuclear RNA sequencing reveals glial diversity associated with cognitive resilience in the AD-BXD mouse model of human Alzheimer’s disease
SE Heuer, J Zhang, M Samuels, N Hadad, AR Ouellette, KMS O'Connell, ...
AAIC Neuroscience Next, 2020
AD-Linked TREM2 Mutation Induces Unique Microglial States Associated with Toxic Function in Tauopathy
FA Sayed, L Kodama, J Udeochu, H Mathys, D Le, X Niu, L Mazutis, ...
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