Bruno Laugel
Bruno Laugel
Senior Research Fellow
Verified email at - Homepage
Cited by
Cited by
RcsCDB His‐Asp phosphorelay system negatively regulates the flhDC operon in Escherichia coli
A Francez‐Charlot, B Laugel, A Van Gemert, N Dubarry, F Wiorowski, ...
Molecular microbiology 49 (3), 823-832, 2003
Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor
A Varela-Rohena, PE Molloy, SM Dunn, Y Li, MM Suhoski, RG Carroll, ...
Nature medicine 14 (12), 1390-1395, 2008
Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotoxic T lymphocyte activation and tetramer binding properties
B Laugel, HA van den Berg, E Gostick, DK Cole, L Wooldridge, J Boulter, ...
Journal of Biological Chemistry 282 (33), 23799-23810, 2007
Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface
L Wooldridge, HA van den Berg, M Glick, E Gostick, B Laugel, ...
Journal of Biological Chemistry 280 (30), 27491-27501, 2005
Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition
B Laugel, JM Boulter, N Lissin, A Vuidepot, Y Li, E Gostick, LE Crotty, ...
Journal of Biological Chemistry 280 (3), 1882-1892, 2005
Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens
EW Meermeier, BF Laugel, AK Sewell, AJ Corbett, J Rossjohn, ...
Nature communications 7 (1), 12506, 2016
The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities
SL Hutchinson, L Wooldridge, S Tafuro, B Laugel, M Glick, JM Boulter, ...
Journal of Biological Chemistry 278 (27), 24285-24293, 2003
CD8 controls T cell cross-reactivity
L Wooldridge, B Laugel, J Ekeruche, M Clement, HA van den Berg, ...
The Journal of Immunology 185 (8), 4625-4632, 2010
Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region
L Wooldridge, A Lissina, J Vernazza, E Gostick, B Laugel, SL Hutchinson, ...
European journal of immunology 37 (5), 1323-1333, 2007
The molecular determinants of CD 8 co‐receptor function
DK Cole, B Laugel, M Clement, DA Price, L Wooldridge, AK Sewell
Immunology 137 (2), 139-148, 2012
Adenosine and cAMP signalling skew human dendritic cell differentiation towards a tolerogenic phenotype with defective CD8+ T‐cell priming capacity
J Challier, D Bruniquel, AK Sewell, B Laugel
Immunology 138 (4), 402-410, 2013
The HLA A*0201–restricted hTERT540–548 peptide is not detected on tumor cells by a CTL clone or a high-affinity T-cell receptor
MA Purbhoo, Y Li, DH Sutton, JE Brewer, E Gostick, G Bossi, B Laugel, ...
Molecular cancer therapeutics 6 (7), 2081-2091, 2007
Coreceptor CD8-driven modulation of T cell antigen receptor specificity
HA van den Berg, L Wooldridge, B Laugel, AK Sewell
Journal of theoretical biology 249 (2), 395-408, 2007
Beyond the antigen receptor: editing the genome of T-cells for cancer adoptive cellular therapies
A Lloyd, ON Vickery, B Laugel
Frontiers in immunology 4, 221, 2013
The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells
B Laugel, DK Cole, M Clement, L Wooldridge, DA Price, AK Sewell
Journal of leukocyte biology 90 (6), 1089-1099, 2011
CD8 exerts differential effects on the deployment of cytotoxic T lymphocyte effector functions
B Laugel, DA Price, A Milicic, AK Sewell
European journal of immunology 37 (4), 905-913, 2007
Cladribine inhibits cytokine secretion by T cells independently of deoxycytidine kinase activity
B Laugel, F Borlat, L Galibert, A Vicari, R Weissert, Y Chvatchko, ...
Journal of Neuroimmunology 240, 52-57, 2011
MHC class I molecules with superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs
L Wooldridge, M Clement, A Lissina, ESJ Edwards, K Ladell, J Ekeruche, ...
The Journal of Immunology 184 (7), 3357-3366, 2010
Cellular-level versus receptor-level response threshold hierarchies in T-cell activation
HA van den Berg, K Ladell, K Miners, B Laugel, S Llewellyn-Lacey, ...
Frontiers in immunology 4, 250, 2013
Engineering of isogenic cells deficient for MR1 with a CRISPR/Cas9 lentiviral system: Tools to study microbial antigen processing and presentation to human MR1-restricted T cells
B Laugel, A Lloyd, EW Meermeier, MD Crowther, TR Connor, G Dolton, ...
The Journal of Immunology 197 (3), 971-982, 2016
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