Jon Clardy
Jon Clardy
Professor of Biological Chemistry, Harvard Medical School
Verifierad e-postadress på hms.harvard.edu
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Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products
J Handelsman, MR Rondon, SF Brady, J Clardy, RM Goodman
Chemistry & biology 5 (10), R245-R249, 1998
19851998
Cloning the soil metagenome: a strategy for accessing the genetic and functional diversity of uncultured microorganisms
MR Rondon, PR August, AD Bettermann, SF Brady, TH Grossman, ...
Appl. Environ. Microbiol. 66 (6), 2541-2547, 2000
14612000
Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin
GD Van Duyne, RF Standaert, PA Karplus, SL Schreiber, J Clardy
Journal of molecular biology 229 (1), 105-124, 1993
13061993
Lessons from natural molecules
J Clardy, C Walsh
Nature 432 (7019), 829-837, 2004
12292004
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature
PG Arnison, MJ Bibb, G Bierbaum, AA Bowers, TS Bugni, G Bulaj, ...
Natural product reports 30 (1), 108-160, 2013
10712013
Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria
K Tachibana, PJ Scheuer, Y Tsukitani, H Kikuchi, D Van Engen, J Clardy, ...
Journal of the American Chemical Society 103 (9), 2469-2471, 1981
8961981
Structure of the FKBP12-rapamycin complex interacting with binding domain of human FRAP
J Choi, J Chen, SL Schreiber, J Clardy
Science 273 (5272), 239-242, 1996
8451996
Isolation and structure of bryostatin 1
GR Pettit, CL Herald, DL Doubek, DL Herald, E Arnold, J Clardy
Journal of the American Chemical Society 104 (24), 6846-6848, 1982
8321982
Diarrhetic shellfish toxins
T Yasumoto, M Murata, Y Oshima, M Sano, GK Matsumoto, J Clardy
Tetrahedron 41 (6), 1019-1025, 1985
7301985
D-amino acids trigger biofilm disassembly
I Kolodkin-Gal, D Romero, S Cao, J Clardy, R Kolter, R Losick
Science 328 (5978), 627-629, 2010
6942010
Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex
GD Van Duyne, RF Standaert, PA Karplus, SL Schreiber, J Clardy
Science 252 (5007), 839-842, 1991
6921991
Isolation and structure of brevetoxin B from the" red tide" dinoflagellate Ptychodiscus brevis (Gymnodinium breve)
YY Lin, M Risk, SM Ray, D Van Engen, J Clardy, J Golik, JC James, ...
Journal of the American Chemical Society 103 (22), 6773-6775, 1981
6251981
New antibiotics from bacterial natural products
J Clardy, MA Fischbach, CT Walsh
Nature biotechnology 24 (12), 1541-1550, 2006
5832006
Isolation of antibiotics turbomycin A and B from a metagenomic library of soil microbial DNA
DE Gillespie, SF Brady, AD Bettermann, NP Cianciotto, MR Liles, ...
Appl. Environ. Microbiol. 68 (9), 4301-4306, 2002
5602002
Crystal and molecular structure of dynemicin A: a novel 1, 5-diyn-3-ene antitumor antibiotic
M Konishi, H Ohkuma, T Tsuno, T Oki, GD VanDuyne, J Clardy
Journal of the American Chemical Society 112 (9), 3715-3716, 1990
5081990
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators
H Hieronymus, J Lamb, KN Ross, XP Peng, C Clement, A Rodina, ...
Cancer cell 10 (4), 321-330, 2006
5012006
Tyrosol is a quorum-sensing molecule in Candida albicans
H Chen, M Fujita, Q Feng, J Clardy, GR Fink
Proceedings of the National Academy of Sciences 101 (14), 5048-5052, 2004
4852004
Castanospermine, a 1, 6, 7, 8-tetrahydroxyoctahydroindolizine alkaloid, from seeds of Castanospermum australe
LD Hohenschutz, EA Bell, PJ Jewess, DP Leworthy, RJ Pryce, E Arnold, ...
Phytochemistry 20 (4), 811-814, 1981
4831981
Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters
P Cimermancic, MH Medema, J Claesen, K Kurita, LCW Brown, ...
Cell 158 (2), 412-421, 2014
4602014
Structure of human methionine aminopeptidase-2 complexed with fumagillin
S Liu, J Widom, CW Kemp, CM Crews, J Clardy
Science 282 (5392), 1324-1327, 1998
4541998
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Artiklar 1–20