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Ralph T. Mosley
Ralph T. Mosley
Merck , Pharmasset
Verifierad e-postadress på arbutusbio.com - Startsida
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Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry
SP Rohrer, ET Birzin, RT Mosley, SC Berk, SM Hutchins, DM Shen, ...
Science 282 (5389), 737-740, 1998
5671998
Novel peroxisome proliferator-activated receptor (PPAR) γ and PPARδ ligands produce distinct biological effects
J Berger, MD Leibowitz, TW Doebber, A Elbrecht, B Zhang, G Zhou, ...
Journal of Biological Chemistry 274 (10), 6718-6725, 1999
5541999
Distinct properties and advantages of a novel peroxisome proliferator-activated protein γ selective modulator
JP Berger, AE Petro, KL Macnaul, LJ Kelly, BB Zhang, K Richards, ...
Molecular Endocrinology 17 (4), 662-676, 2003
3992003
Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase
MJ Sofia, W Chang, PA Furman, RT Mosley, BS Ross
Journal of medicinal chemistry 55 (6), 2481-2531, 2012
3492012
Chemical similarity using physiochemical property descriptors
SK Kearsley, S Sallamack, EM Fluder, JD Andose, RT Mosley, ...
Journal of Chemical Information and Computer Sciences 36 (1), 118-127, 1996
3491996
What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases
JF Evans, AD Ferguson, RT Mosley, JH Hutchinson
Trends in pharmacological sciences 29 (2), 72-78, 2008
2932008
Molecular determinants of ligand binding to the human melanocortin-4 receptor
Y Yang, TM Fong, CJ Dickinson, C Mao, JY Li, MR Tota, R Mosley, ...
Biochemistry 39 (48), 14900-14911, 2000
2262000
Design and Pharmacology of N-[(3 R)-1, 2, 3, 4-Tetrahydroisoquinolinium-3-ylcarbonyl]-(1 R)-1-(4-chlorobenzyl)-2-[4-cyclohexyl-4-(1 H-1, 2, 4-triazol-1-ylmethyl) piperidin-1-yl …
IK Sebhat, WJ Martin, Z Ye, K Barakat, RT Mosley, DBR Johnston, ...
Journal of medicinal chemistry 45 (21), 4589-4593, 2002
2252002
Selective small-molecule agonists of G protein–coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice
CP Tan, Y Feng, YP Zhou, GJ Eiermann, A Petrov, C Zhou, S Lin, ...
Diabetes 57 (8), 2211-2219, 2008
2102008
Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2
L Yang, SC Berk, SP Rohrer, RT Mosley, L Guo, DJ Underwood, ...
Proceedings of the National Academy of Sciences 95 (18), 10836-10841, 1998
1781998
Structure and chemistry of apicidins, a class of novel cyclic tetrapeptides without a terminal α-keto epoxide as inhibitors of histone deacetylase with potent antiprotozoal …
SB Singh, DL Zink, JM Liesch, RT Mosley, AW Dombrowski, GF Bills, ...
The Journal of Organic Chemistry 67 (3), 815-825, 2002
1742002
6H-Benzo [c] chromen-6-one derivatives as selective ERβ agonists
W Sun, LD Cama, ET Birzin, S Warrier, L Locco, R Mosley, ML Hammond, ...
Bioorganic & medicinal chemistry letters 16 (6), 1468-1472, 2006
1702006
Isolation and structure of chaetomellic acids A and B from Chaetomella acutiseta: farnesyl pyrophosphate mimic inhibitors of Ras farnesyl-protein transferase
SB Singh, DL Zink, JM Liesch, MA Goetz, RG Jenkins, M Nallin-Omstead, ...
Tetrahedron 49 (27), 5917-5926, 1993
1431993
Structure of hepatitis C virus polymerase in complex with primer-template RNA
RT Mosley, TE Edwards, E Murakami, AM Lam, RL Grice, J Du, MJ Sofia, ...
Journal of virology 86 (12), 6503-6511, 2012
1412012
Molecular interaction of Agouti protein and Agouti-related protein with human melanocortin receptors
MR Tota, TS Smith, C Mao, T MacNeil, RT Mosley, LHT Van der Ploeg, ...
Biochemistry 38 (3), 897-904, 1999
1401999
Attenuating pregnane X receptor (PXR) activation: a molecular modelling approach
YD Gao, SH Olson, JM Balkovec, Y Zhu, I Royo, J Yabut, R Evers, EY Tan, ...
Xenobiotica 37 (2), 124-138, 2007
1142007
Estrogen receptor ligands. II. Discovery of benzoxathiins as potent, selective estrogen receptor α modulators
S Kim, JY Wu, ET Birzin, K Frisch, W Chan, LY Pai, YT Yang, RT Mosley, ...
Journal of medicinal chemistry 47 (9), 2171-2175, 2004
1062004
Discovery of 5-aryloxy-2, 4-thiazolidinediones as potent GPR40 agonists
C Zhou, C Tang, E Chang, M Ge, S Lin, E Cline, CP Tan, Y Feng, YP Zhou, ...
Bioorganic & Medicinal Chemistry Letters 20 (3), 1298-1301, 2010
972010
The differential interactions of peroxisome proliferator-activated receptor γ ligands with Tyr473 is a physical basis for their unique biological activities
M Einstein, TE Akiyama, GA Castriota, CF Wang, B McKeever, RT Mosley, ...
Molecular Pharmacology 73 (1), 62-74, 2008
922008
Selective PPARγ modulators with improved pharmacological profiles
K Liu, RM Black, JJ Acton III, R Mosley, S Debenham, R Abola, M Yang, ...
Bioorganic & medicinal chemistry letters 15 (10), 2437-2440, 2005
792005
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