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Kresten Skak
Kresten Skak
Senior Director, Inflammation, Dragonfly Therapeutics CPH
Verified email at dragonflytx.com
Title
Cited by
Cited by
Year
An open-label, two-arm, phase I trial of recombinant human interleukin-21 in patients with metastatic melanoma
ID Davis, BK Skrumsager, J Cebon, T Nicholaou, JW Barlow, NPH Moller, ...
Clinical Cancer Research 13 (12), 3630-3636, 2007
1882007
Interleukin‐21 activates human natural killer cells and modulates their surface receptor expression
K Skak, KS Frederiksen, D Lundsgaard
Immunology 123 (4), 575-583, 2008
1672008
Clinical and biological efficacy of recombinant human interleukin-21 in patients with stage IV malignant melanoma without prior treatment: a phase IIa trial
ID Davis, B Brady, RF Kefford, M Millward, J Cebon, BK Skrumsager, ...
Clinical Cancer Research 15 (6), 2123-2129, 2009
1602009
IL-21 induces in vivo immune activation of NK cells and CD8+ T cells in patients with metastatic melanoma and renal cell carcinoma
KS Frederiksen, D Lundsgaard, JA Freeman, SD Hughes, TL Holm, ...
Cancer Immunology, Immunotherapy 57, 1439-1449, 2008
1382008
Interleukin 21: combination strategies for cancer therapy
K Skak, M Kragh, D Hausman, MJ Smyth, PV Sivakumar
Nature reviews Drug discovery 7 (3), 231-240, 2008
1302008
Interleukin-21 signaling: functions in cancer and autoimmunity
ID Davis, K Skak, MJ Smyth, PEG Kristjansen, DM Miller, PV Sivakumar
Clinical cancer research 13 (23), 6926-6932, 2007
1152007
Histone deacetylase inhibitors: a new class of immunosuppressors targeting a novel signal pathway essential for CD154 expression
S Skov, K Rieneck, LF Bovin, K Skak, S Tomra, BK Michelsen, N Ødum
Blood, The Journal of the American Society of Hematology 101 (4), 1430-1438, 2003
1062003
IL‐21: roles in immunopathology and cancer therapy
H Søndergaard, K Skak
Tissue antigens 74 (6), 467-479, 2009
902009
Interleukin 21 therapy increases the density of tumor infiltrating CD8+ T cells and inhibits the growth of syngeneic tumors
H Søndergaard, KS Frederiksen, P Thygesen, ED Galsgaard, K Skak, ...
Cancer Immunology, Immunotherapy 56, 1417-1428, 2007
872007
Distinct molecular signatures of mild extrinsic and intrinsic atopic dermatitis
BC Martel, T Litman, A Hald, H Norsgaard, P Lovato, B Dyring‐Andersen, ...
Experimental dermatology 25 (6), 453-459, 2016
752016
Improved β-Cell Survival and Reduced Insulitis in a Type 1 Diabetic Rat Model After Treatment With a β-Cell–Selective KATP Channel Opener
K Skak, CF Gotfredsen, D Lundsgaard, JB Hansen, J Sturis, H Markholst
Diabetes 53 (4), 1089-1095, 2004
532004
IL-21 induces apoptosis of antigen-specific CD8+ T lymphocytes
BR Barker, JG Parvani, D Meyer, AS Hey, K Skak, NL Letvin
The Journal of Immunology 179 (6), 3596-3603, 2007
442007
Ingenol mebutate signals via PKC/MEK/ERK in keratinocytes and induces interleukin decoy receptors IL1R2 and IL13RA2
SN Freiberger, PF Cheng, G Iotzova-Weiss, J Neu, Q Liu, P Dziunycz, ...
Molecular cancer therapeutics 14 (9), 2132-2142, 2015
422015
Intratumoral interleukin-21 increases antitumor immunity, tumor-infiltrating CD8+ T-cell density and activity, and enlarges draining lymph nodes
H Søndergaard, ED Galsgaard, M Bartholomaeussen, PT Straten, ...
Journal of Immunotherapy 33 (3), 236-249, 2010
402010
The combination of IL-21 and IFN-α boosts STAT3 activation, cytotoxicity and experimental tumor therapy
KW Eriksen, H Søndergaard, A Woetmann, T Krejsgaard, K Skak, ...
Molecular immunology 46 (5), 812-820, 2009
312009
The TATA-less rat GAD65 promoter can be activated by Sp1 through non-consensus elements
K Skak, BK Michelsen
Gene 236 (2), 231-241, 1999
301999
IL‐21 Modulates Activation of NKT Cells in Patients with Stage IV Malignant Melanoma
JM Coquet, K Skak, ID Davis, MJ Smyth, DI Godfrey
Clinical & translational immunology 2 (10), e6, 2013
272013
Endogenous IL-21 restricts CD8+ T cell expansion and is not required for tumor immunity
H Søndergaard, JM Coquet, AP Uldrich, N McLaughlin, DI Godfrey, ...
The Journal of Immunology 183 (11), 7326-7336, 2009
242009
Immune activation in advanced cancer patients treated with recombinant IL-21: multianalyte profiling of serum proteins
MG Dodds, KS Frederiksen, K Skak, LT Hansen, D Lundsgaard, ...
Cancer immunology, immunotherapy 58, 843-854, 2009
232009
Local activation of dendritic cells leads to insulitis and development of insulin-dependent diabetes in transgenic mice expressing CD154 on the pancreatic β-cells
C Haase, K Skak, BK Michelsen, H Markholst
Diabetes 53 (10), 2588-2595, 2004
222004
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