| Bridging the NFAT and NF-κB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress C López-Rodrı́guez, J Aramburu, L Jin, AS Rakeman, M Michino, A Rao Immunity 15 (1), 47-58, 2001 | 307 | 2001 |
| Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008 M Michino, E Abola, GPCR Dock 2008 Participants, CL Brooks III, ... Nature Reviews Drug Discovery 8 (6), 455-463, 2009 | 304 | 2009 |
| Molecular determinants of selectivity and efficacy at the dopamine D3 receptor AH Newman, T Beuming, AK Banala, P Donthamsetti, K Pongetti, ... Journal of medicinal chemistry 55 (15), 6689-6699, 2012 | 186 | 2012 |
| Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression L Lama, C Adura, W Xie, D Tomita, T Kamei, V Kuryavyi, T Gogakos, ... Nature Communications 10 (1), 2261, 2019 | 156 | 2019 |
| A new mechanism of allostery in a G protein–coupled receptor dimer JR Lane, P Donthamsetti, J Shonberg, CJ Draper-Joyce, S Dentry, ... Nature chemical biology 10 (9), 745-752, 2014 | 125 | 2014 |
| What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands? M Michino, T Beuming, P Donthamsetti, AH Newman, JA Javitch, L Shi Pharmacological Reviews 67 (1), 198-213, 2015 | 120 | 2015 |
| Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance LA Kirkman, W Zhan, J Visone, A Dziedziech, PK Singh, H Fan, X Tong, ... Proceedings of the National Academy of Sciences 115 (29), E6863-E6870, 2018 | 80 | 2018 |
| A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors M Michino, P Donthamsetti, T Beuming, A Banala, L Duan, T Roux, Y Han, ... Molecular pharmacology 84 (6), 854-864, 2013 | 64 | 2013 |
| Computational approaches to detect allosteric pathways in transmembrane molecular machines S Stolzenberg, M Michino, MV LeVine, H Weinstein, L Shi Biochimica et Biophysica Acta (BBA)-Biomembranes 1858 (7), 1652-1662, 2016 | 61 | 2016 |
| Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic Ligand SN Mistry, J Shonberg, CJ Draper-Joyce, C Klein Herenbrink, M Michino, ... Journal of medicinal chemistry 58 (17), 6819-6843, 2015 | 54 | 2015 |
| Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D3 Receptor M Michino, CA Boateng, P Donthamsetti, H Yano, OM Bakare, A Bonifazi, ... Journal of medicinal chemistry 60 (2), 580-593, 2017 | 53 | 2017 |
| Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells E Mullarky, J Xu, AD Robin, DJ Huggins, A Jennings, N Noguchi, A Olland, ... Bioorganic & medicinal chemistry letters 29 (17), 2503-2510, 2019 | 44 | 2019 |
| FoldGPCR: Structure prediction protocol for the transmembrane domain of G protein‐coupled receptors from class A M Michino, J Chen, RC Stevens, CL Brooks III Proteins: Structure, Function, and Bioinformatics 78 (10), 2189-2201, 2010 | 42 | 2010 |
| Improved model building and assessment of the calcium‐sensing receptor transmembrane domain L Bu, M Michino, RM Wolf, CL Brooks III Proteins: Structure, Function, and Bioinformatics 71 (1), 215-226, 2008 | 38 | 2008 |
| Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor … MF Zou, TM Keck, V Kumar, P Donthamsetti, M Michino, C Burzynski, ... Journal of medicinal chemistry 59 (7), 2973-2988, 2016 | 36 | 2016 |
| Structural basis for Na+-sensitivity in dopamine D2 and D3 receptors M Michino, RB Free, TB Doyle, DR Sibley, L Shi Chemical communications 51 (41), 8618-8621, 2015 | 34 | 2015 |
| Enhancing hit discovery in virtual screening through absolute protein–ligand binding free-energy calculations W Chen, D Cui, SV Jerome, M Michino, EB Lenselink, DJ Huggins, ... Journal of Chemical Information and Modeling 63 (10), 3171-3185, 2023 | 30 | 2023 |
| The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor CJ Draper-Joyce, M Michino, RK Verma, CK Herenbrink, J Shonberg, ... Biochemical pharmacology 148, 315-328, 2018 | 28 | 2018 |
| Small-molecule inhibition of the acyl-lysine reader ENL as a strategy against acute myeloid leukemia Y Liu, Q Li, F Alikarami, DR Barrett, L Mahdavi, H Li, S Tang, TA Khan, ... Cancer discovery 12 (11), 2684-2709, 2022 | 25 | 2022 |
| Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti‐malaria Activity in Humanized Mice W Zhan, H Zhang, J Ginn, A Leung, YJ Liu, M Michino, A Toita, ... Angewandte Chemie 133 (17), 9365-9369, 2021 | 21 | 2021 |
