Steven Fletcher
Steven Fletcher
Associate Professor of Chemistry at the University of Maryland
Verified email at
Cited by
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A novel small-molecule disrupts Stat3 SH2 domain–phosphotyrosine interactions and Stat3-dependent tumor processes
X Zhang, P Yue, S Fletcher, W Zhao, PT Gunning, J Turkson
Biochemical pharmacology 79 (10), 1398-1409, 2010
The Mitsunobu reaction in the 21 st century
S Fletcher
Organic Chemistry Frontiers 2 (6), 739-752, 2015
Targeting protein–protein interactions by rational design: mimicry of protein surfaces
S Fletcher, AD Hamilton
Journal of the Royal Society Interface 3 (7), 215-233, 2006
Protein surface recognition and proteomimetics: mimics of protein surface structure and function
S Fletcher, AD Hamilton
Current opinion in chemical biology 9 (6), 632-638, 2005
Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein
S Fletcher, J Turkson, PT Gunning
ChemMedChem 3 (8), 1159, 2008
Small-molecule inhibitors of the Myc oncoprotein
S Fletcher, EV Prochownik
Biochimica Et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1849 (5), 525-543, 2015
Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein
S Fletcher, JA Drewry, VM Shahani, BDG Page, PT Gunning
Biochemistry and Cell Biology 87 (6), 825-833, 2009
The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition
C Peddaboina, D Jupiter, S Fletcher, JL Yap, A Rai, RP Tobin, W Jiang, ...
BMC cancer 12 (1), 1-12, 2012
Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities
S Fletcher, J Singh, X Zhang, P Yue, BDG Page, S Sharmeen, ...
Chembiochem: a European journal of chemical biology 10 (12), 1959, 2009
Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity
BDG Page, H Khoury, RC Laister, S Fletcher, M Vellozo, A Manzoli, P Yue, ...
Journal of medicinal chemistry 55 (3), 1047-1055, 2012
Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain
P Mistry, MHW Laird, RS Schwarz, S Greene, T Dyson, GA Snyder, ...
Proceedings of the National Academy of Sciences 112 (17), 5455-5460, 2015
Protein-protein interaction inhibitors: small molecules from screening techniques
S Fletcher, AD Hamilton
Current topics in medicinal chemistry 7 (10), 922-927, 2007
The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein–protein …
X Cao, JL Yap, MK Newell-Rogers, C Peddaboina, W Jiang, ...
Molecular cancer 12 (1), 1-16, 2013
Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: Identification of potent Bcl-x L inhibitors
JL Yap, X Cao, K Vanommeslaeghe, KY Jung, C Peddaboina, PT Wilder, ...
Organic & biomolecular chemistry 10 (15), 2928-2933, 2012
Perturbation of the c-Myc–Max protein–protein interaction via synthetic α-helix mimetics
KY Jung, H Wang, P Teriete, JL Yap, L Chen, ME Lanning, A Hu, ...
Journal of medicinal chemistry 58 (7), 3002-3024, 2015
Small Molecule Inhibitors of the ERK Signalling Pathway: Towards Novel Anti-cancer Therapeutics
JL Yap, S Worlikar, AD MacKerell Jr, P Shapiro, S Fletcher
ChemMedChem 6 (1), 38, 2011
BRD4 structure–activity relationships of dual PLK1 kinase/BRD4 bromodomain inhibitor BI-2536
L Chen, JL Yap, M Yoshioka, ME Lanning, RN Fountain, M Raje, ...
ACS medicinal chemistry letters 6 (7), 764-769, 2015
An activatable multimodal/multifunctional nanoprobe for direct imaging of intracellular drug delivery
RN Mitra, M Doshi, X Zhang, JC Tyus, N Bengtsson, S Fletcher, ...
Biomaterials 33 (5), 1500-1508, 2012
Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain
BDG Page, S Fletcher, P Yue, Z Li, X Zhang, S Sharmeen, A Datti, ...
Bioorganic & medicinal chemistry letters 21 (18), 5605-5609, 2011
Mild, efficient and rapid O-debenzylation of ortho-substituted phenols with trifluoroacetic acid
S Fletcher, PT Gunning
Tetrahedron Letters 49 (33), 4817-4819, 2008
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