| Targeting protein–protein interactions by rational design: mimicry of protein surfaces S Fletcher, AD Hamilton Journal of the Royal Society Interface 3 (7), 215-233, 2006 | 167 | 2006 |
| A novel small-molecule disrupts Stat3 SH2 domain–phosphotyrosine interactions and Stat3-dependent tumor processes X Zhang, P Yue, S Fletcher, W Zhao, PT Gunning, J Turkson Biochemical pharmacology 79 (10), 1398-1409, 2010 | 163 | 2010 |
| Protein surface recognition and proteomimetics: mimics of protein surface structure and function S Fletcher, AD Hamilton Current opinion in chemical biology 9 (6), 632-638, 2005 | 137 | 2005 |
| Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein S Fletcher, J Turkson, PT Gunning ChemMedChem: Chemistry Enabling Drug Discovery 3 (8), 1159-1168, 2008 | 129 | 2008 |
| The Mitsunobu reaction in the 21 st century S Fletcher Organic Chemistry Frontiers 2 (6), 739-752, 2015 | 114 | 2015 |
| Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein S Fletcher, JA Drewry, VM Shahani, BDG Page, PT Gunning Biochemistry and Cell Biology 87 (6), 825-833, 2009 | 109 | 2009 |
| Disruption of Transcriptionally Active Stat3 Dimers with Non‐phosphorylated, Salicylic Acid‐Based Small Molecules: Potent in vitro and Tumor Cell Activities S Fletcher, J Singh, X Zhang, P Yue, BDG Page, S Sharmeen, ... ChemBioChem 10 (12), 1959-1964, 2009 | 100 | 2009 |
| Protein-protein interaction inhibitors: small molecules from screening techniques S Fletcher, AD Hamilton Current topics in medicinal chemistry 7 (10), 922-927, 2007 | 95 | 2007 |
| Small-molecule inhibitors of the Myc oncoprotein S Fletcher, EV Prochownik Biochimica Et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1849 (5), 525-543, 2015 | 94 | 2015 |
| The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition C Peddaboina, D Jupiter, S Fletcher, JL Yap, A Rai, RP Tobin, W Jiang, ... BMC cancer 12 (1), 541, 2012 | 87 | 2012 |
| Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity BDG Page, H Khoury, RC Laister, S Fletcher, M Vellozo, A Manzoli, P Yue, ... Journal of medicinal chemistry 55 (3), 1047-1055, 2012 | 83 | 2012 |
| The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein–protein … X Cao, JL Yap, MK Newell-Rogers, C Peddaboina, W Jiang, ... Molecular cancer 12 (1), 42, 2013 | 73 | 2013 |
| Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: Identification of potent Bcl-x L inhibitors JL Yap, X Cao, K Vanommeslaeghe, KY Jung, C Peddaboina, PT Wilder, ... Organic & biomolecular chemistry 10 (15), 2928-2933, 2012 | 68 | 2012 |
| An activatable multimodal/multifunctional nanoprobe for direct imaging of intracellular drug delivery RN Mitra, M Doshi, X Zhang, JC Tyus, N Bengtsson, S Fletcher, ... Biomaterials 33 (5), 1500-1508, 2012 | 62 | 2012 |
| Small‐molecule inhibitors of the ERK signaling pathway: Towards novel anticancer therapeutics JL Yap, S Worlikar, AD MacKerell Jr, P Shapiro, S Fletcher ChemMedChem 6 (1), 38-48, 2011 | 62 | 2011 |
| Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain P Mistry, MHW Laird, RS Schwarz, S Greene, T Dyson, GA Snyder, ... Proceedings of the National Academy of Sciences 112 (17), 5455-5460, 2015 | 61 | 2015 |
| Mild, efficient and rapid O-debenzylation of ortho-substituted phenols with trifluoroacetic acid S Fletcher, PT Gunning Tetrahedron Letters 49 (33), 4817-4819, 2008 | 61 | 2008 |
| Protein recognition and denaturation by self‐assembling fragments on a DNA quadruplex scaffold DM Tagore, KI Sprinz, S Fletcher, J Jayawickramarajah, AD Hamilton Angewandte Chemie International Edition 46 (1‐2), 223-225, 2007 | 59 | 2007 |
| Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain BDG Page, S Fletcher, P Yue, Z Li, X Zhang, S Sharmeen, A Datti, ... Bioorganic & medicinal chemistry letters 21 (18), 5605-5609, 2011 | 57 | 2011 |
| Antagonism of the Stat3–Stat3 protein dimer with salicylic acid based small molecules S Fletcher, BDG Page, X Zhang, P Yue, ZH Li, S Sharmeen, J Singh, ... ChemMedChem 6 (8), 1459-1470, 2011 | 51 | 2011 |
Patrick T. GunningCanada Research Chair and Associate Professor of ChemistryVerified email at utoronto.ca
