Karen van Eunen
Karen van Eunen
Section Systems Medicine of Metabolism and Signalling, Department of Pediatrics, UMCG
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The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
G Den Besten, K Van Eunen, AK Groen, K Venema, DJ Reijngoud, ...
Journal of lipid research 54 (9), 2325-2340, 2013
Short-chain fatty acids protect against high-fat diet–induced obesity via a PPARγ-dependent switch from lipogenesis to fat oxidation
G Den Besten, A Bleeker, A Gerding, K van Eunen, R Havinga, ...
Diabetes 64 (7), 2398-2408, 2015
Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids
G den Besten, K Lange, R Havinga, TH van Dijk, A Gerding, K van Eunen, ...
American Journal of Physiology-Gastrointestinal and Liver Physiology 305 (12 …, 2013
Measuring enzyme activities under standardized in vivo‐like conditions for systems biology
K Van Eunen, J Bouwman, P Daran‐Lapujade, J Postmus, AB Canelas, ...
The FEBS journal 277 (3), 749-760, 2010
A systems study reveals concurrent activation of AMPK and mTOR by amino acids
P Dalle Pezze, S Ruf, AG Sonntag, M Langelaar-Makkinje, P Hall, ...
Nature communications 7 (1), 13254, 2016
Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains
AB Canelas, N Harrison, A Fazio, J Zhang, JP Pitkänen, J Van Den Brink, ...
Nature communications 1 (1), 145, 2010
Protection against the metabolic syndrome by guar gum-derived short-chain fatty acids depends on peroxisome proliferator-activated receptor γ and glucagon-like peptide-1
G den Besten, A Gerding, TH van Dijk, J Ciapaite, A Bleeker, K van Eunen, ...
PloS one 10 (8), e0136364, 2015
Testing Biochemistry Revisited: How In Vivo Metabolism Can Be Understood from In Vitro Enzyme Kinetics
K van Eunen, JAL Kiewiet, HV Westerhoff, BM Bakker
PLoS computational biology 8 (4), e1002483, 2012
Molecular mechanisms of mTOR regulation by stress
AM Heberle, MT Prentzell, K Van Eunen, BM Bakker, SN Grellscheid, ...
Molecular & cellular oncology 2 (2), e970489, 2015
The short-chain fatty acid uptake fluxes by mice on a guar gum supplemented diet associate with amelioration of major biomarkers of the metabolic syndrome
G den Besten, R Havinga, A Bleeker, S Rao, A Gerding, K van Eunen, ...
PloS one 9 (9), e107392, 2014
Biochemical competition makes fatty-acid β-oxidation vulnerable to substrate overload
K van Eunen, SMJ Simons, A Gerding, A Bleeker, G den Besten, ...
PLoS computational biology 9 (8), e1003186, 2013
A model reduction method for biochemical reaction networks
S Rao, A der Schaft, K Eunen, BM Bakker, B Jayawardhana
BMC systems biology 8, 1-17, 2014
Translational targeted proteomics profiling of mitochondrial energy metabolic pathways in mouse and human samples
JC Wolters, J Ciapaite, K Van Eunen, KE Niezen-Koning, A Matton, ...
Journal of proteome research 15 (9), 3204-3213, 2016
The importance and challenges of in vivo-like enzyme kinetics
K van Eunen, BM Bakker
Perspectives in Science 1 (1-6), 126-130, 2014
Gene flow between arrhenotokous and thelytokous populations of Venturia canescens (Hymenoptera)
MV Schneider, G Driessen, LW Beukeboom, R Boll, K Van Eunen, ...
Heredity 90 (3), 260-267, 2003
Metabolic regulation rather than de novo enzyme synthesis dominates the osmo‐adaptation of yeast
J Bouwman, J Kiewiet, A Lindenbergh, K van Eunen, M Siderius, ...
Yeast 28 (1), 43-53, 2011
The promiscuous enzyme medium-chain 3-keto-acyl-CoA thiolase triggers a vicious cycle in fatty-acid beta-oxidation
ACMF Martines, K Van Eunen, DJ Reijngoud, BM Bakker
PLoS computational biology 13 (4), e1005461, 2017
Simultaneous induction of glycolysis and oxidative phosphorylation during activation of hepatic stellate cells reveals novel mitochondrial targets to treat liver fibrosis
N Smith-Cortinez, K van Eunen, J Heegsma, SA Serna-Salas, S Sydor, ...
Cells 9 (11), 2456, 2020
Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids
P Riemer, M Rydenfelt, M Marks, K van Eunen, K Thedieck, BG Herrmann, ...
Journal of Cell Biology 216 (6), 1567-1577, 2017
Living on the edge: substrate competition explains loss of robustness in mitochondrial fatty-acid oxidation disorders
K van Eunen, CML Volker-Touw, A Gerding, A Bleeker, JC Wolters, ...
BMC biology 14, 1-15, 2016
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