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Federica Cossu
Federica Cossu
Istituto di Biofisica - UOS Milano - Consiglio Nazionale delle Ricerche
Verifierad e-postadress på guest.unimi.it
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Targeting the BIR domains of inhibitor of apoptosis (IAP) proteins in cancer treatment
F Cossu, M Milani, E Mastrangelo, D Lecis
Computational and Structural Biotechnology Journal 17, 142-150, 2019
832019
Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2
F Cossu, E Mastrangelo, M Milani, G Sorrentino, D Lecis, D Delia, ...
Biochemical and biophysical research communications 378 (2), 162-167, 2009
722009
TREX1 C-terminal frameshift mutations in the systemic variant of retinal vasculopathy with cerebral leukodystrophy
JC DiFrancesco, F Novara, O Zuffardi, A Forlino, R Gioia, F Cossu, ...
Neurological sciences 36, 323-330, 2015
662015
Structural basis for bivalent Smac-mimetics recognition in the IAP protein family
F Cossu, M Milani, E Mastrangelo, P Vachette, F Servida, D Lecis, ...
Journal of molecular biology 392 (3), 630-644, 2009
522009
Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo [5.3. 0] alkane smac mimetics. Structure, activity, and recognition principles
E Mastrangelo, F Cossu, M Milani, G Sorrentino, D Lecis, D Delia, ...
Journal of molecular biology 384 (3), 673-689, 2008
492008
Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization
D Lecis, E Mastrangelo, L Belvisi, M Bolognesi, M Civera, F Cossu, ...
Bioorganic & medicinal chemistry 20 (22), 6709-6723, 2012
352012
Kinetic and structural evidences on human prolidase pathological mutants suggest strategies for enzyme functional rescue
R Besio, R Gioia, F Cossu, E Monzani, S Nicolis, L Cucca, A Profumo, ...
PloS one 8 (3), e58792, 2013
282013
Recognition of Smac‐mimetic compounds by the BIR domain of cIAP1
F Cossu, F Malvezzi, G Canevari, E Mastrangelo, D Lecis, D Delia, ...
Protein science 19 (12), 2418-2429, 2010
262010
The activator of apoptosis Smac-DIABLO acts as a tetramer in solution
E Mastrangelo, P Vachette, F Cossu, F Malvezzi, M Bolognesi, M Milani
Biophysical Journal 108 (3), 714-723, 2015
232015
Cellulose production is coupled to sensing of the pyrimidine biosynthetic pathway via c‐di‐GMP production by the DgcQ protein of Escherichia coli
E Rossi, S Motta, A Aliverti, F Cossu, L Gourlay, P Mauri, P Landini
Environmental microbiology 19 (11), 4551-4563, 2017
202017
Structural insight into inhibitor of apoptosis proteins recognition by a potent divalent smac-mimetic
F Cossu, M Milani, P Vachette, F Malvezzi, S Grassi, D Lecis, D Delia, ...
PLoS One 7 (11), e49527, 2012
202012
Homo-and heterodimeric SMAC mimetic compounds as apoptosis inducers
P Seneci, L Belvisi, F Cossu, D Delia, C Drago, D Lecis, S Maiorana, ...
US Patent 9,321,808, 2016
162016
Structure‐based design and molecular profiling of Smac‐mimetics selective for cellular IAP s
A Corti, M Milani, D Lecis, P Seneci, M de Rosa, E Mastrangelo, F Cossu
The FEBS journal 285 (17), 3286-3298, 2018
122018
Structural bases of the altered catalytic properties of a pathogenic variant of apoptosis inducing factor
L Sorrentino, F Cossu, M Milani, A Aliverti, E Mastrangelo
Biochemical and Biophysical Research Communications 490 (3), 1011-1017, 2017
122017
NF023 binding to XIAP‐BIR1: Searching drugs for regulation of the NF‐κB pathway
F Cossu, M Milani, S Grassi, F Malvezzi, A Corti, M Bolognesi, ...
Proteins: Structure, Function, and Bioinformatics 83 (4), 612-620, 2015
122015
Novel neurofibromatosis type 2 mutation presenting with status epilepticus
JC DiFrancesco, R Sestini, F Cossu, M Bolognesi, E Sala, S Mariani, ...
Epileptic Disorders 16 (1), 132-137, 2014
122014
A NMR and computational study of Smac mimics targeting both the BIR2 and BIR3 domains in XIAP protein
D Potenza, L Belvisi, F Vasile, E Moroni, F Cossu, P Seneci
Organic & biomolecular chemistry 10 (16), 3278-3287, 2012
102012
Structure-based identification of a new IAP-targeting compound that induces cancer cell death inducing NF-κB pathway
F Cossu, S Camelliti, D Lecis, L Sorrentino, MT Majorini, M Milani, ...
Computational and Structural Biotechnology Journal 19, 6366-6374, 2021
72021
Structure‐Activity Relationship of NF023 Derivatives Binding to XIAP‐BIR1
L Sorrentino, F Cossu, M Milani, B Malkoc, WC Huang, SC Tsay, ...
ChemistryOpen 8 (4), 476-482, 2019
62019
Computational and experimental characterization of NF023, A candidate anticancer compound inhibiting cIAP2/TRAF2 assembly
F Cossu, L Sorrentino, E Fagnani, M Zaffaroni, M Milani, T Giorgino, ...
Journal of Chemical Information and Modeling 60 (10), 5036-5044, 2020
32020
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Artiklar 1–20