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Wojciech Michno
Wojciech Michno
Uppsala University, SciLifeLab
Verified email at scilifelab.uu.se
Title
Cited by
Cited by
Year
Novel trimodal MALDI imaging mass spectrometry (IMS3) at 10 μm reveals spatial lipid and peptide correlates implicated in Aβ plaque pathology in Alzheimer’s disease
I Kaya, D Brinet, W Michno, M Başkurt, H Zetterberg, K Blenow, ...
ACS chemical neuroscience 8 (12), 2778-2790, 2017
1002017
Delineating amyloid plaque associated neuronal sphingolipids in transgenic Alzheimer’s disease mice (tgArcSwe) using MALDI imaging mass spectrometry
I Kaya, D Brinet, W Michno, S Syvänen, D Sehlin, H Zetterberg, ...
ACS chemical neuroscience 8 (2), 347-355, 2017
772017
Histology-compatible MALDI mass spectrometry based imaging of neuronal lipids for subsequent immunofluorescent staining
I Kaya, W Michno, D Brinet, Y Iacone, G Zanni, K Blennow, H Zetterberg, ...
Analytical chemistry 89 (8), 4685-4694, 2017
742017
Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer’s disease pathology
W Michno, S Nyström, P Wehrli, T Lashley, G Brinkmalm, L Guerard, ...
Journal of Biological Chemistry 294 (17), 6719-6732, 2019
652019
Lithium accumulates in neurogenic brain regions as revealed by high resolution ion imaging
G Zanni, W Michno, E Di Martino, A Tjärnlund-Wolf, J Pettersson, ...
Scientific reports 7 (1), 40726, 2017
492017
Probing amyloid‐β pathology in transgenic Alzheimer's disease (tgArcSwe) mice using MALDI imaging mass spectrometry
L Carlred, W Michno, I Kaya, P Sjövall, S Syvänen, J Hanrieder
Journal of neurochemistry 138 (3), 469-478, 2016
482016
Molecular imaging mass spectrometry for probing protein dynamics in neurodegenerative disease pathology
W Michno, PM Wehrli, K Blennow, H Zetterberg, J Hanrieder
Journal of neurochemistry 151 (4), 488-506, 2019
472019
Multimodal chemical imaging of amyloid plaque polymorphism reveals Aβ aggregation dependent anionic lipid accumulations and metabolism
W Michno, I Kaya, S Nyström, L Guerard, KPR Nilsson, ...
Analytical chemistry 90 (13), 8130-8138, 2018
432018
GM1 locates to mature amyloid structures implicating a prominent role for glycolipid-protein interactions in Alzheimer pathology
W Michno, PM Wehrli, H Zetterberg, K Blennow, J Hanrieder
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1867 (5), 458-467, 2019
422019
Aggregated Aβ1-42 is selectively toxic for neurons, whereas glial cells produce mature fibrils with low toxicity in Drosophila
M Jonson, S Nyström, A Sandberg, M Carlback, W Michno, J Hanrieder, ...
Cell chemical biology 25 (5), 595-610. e5, 2018
332018
Following spatial Aβ aggregation dynamics in evolving Alzheimer’s disease pathology by imaging stable isotope labeling kinetics
W Michno, KM Stringer, T Enzlein, MK Passarelli, S Escrig, K Vitanova, ...
Science Advances 7 (25), eabg4855, 2021
272021
The Uppsala APP deletion causes early onset autosomal dominant Alzheimer’s disease by altering APP processing and increasing amyloid β fibril formation
M Pagnon de la Vega, V Giedraitis, W Michno, L Kilander, G Güner, ...
Science translational medicine 13 (606), eabc6184, 2021
252021
Computational analysis of Alzheimer amyloid plaque composition in 2D-and elastically reconstructed 3D-MALDI MS images
T Enzlein, J Cordes, B Munteanu, W Michno, L Serneels, B De Strooper, ...
Analytical chemistry 92 (21), 14484-14493, 2020
202020
Chemical imaging of evolving amyloid plaque pathology and associated Aβ peptide aggregation in a transgenic mouse model of Alzheimer’s disease
W Michno, P Wehrli, SR Meier, D Sehlin, S Syvänen, H Zetterberg, ...
Journal of Neurochemistry 152 (5), 602-616, 2020
202020
Structural amyloid plaque polymorphism is associated with distinct lipid accumulations revealed by trapped ion mobility mass spectrometry imaging
W Michno, PM Wehrli, S Koutarapu, C Marsching, K Minta, J Ge, ...
Journal of Neurochemistry 160 (4), 482-498, 2022
192022
MALDI imaging delineates hippocampal glycosphingolipid changes associated with neurotoxin induced proteopathy following neonatal BMAA exposure
O Karlsson, W Michno, Y Ransome, J Hanrieder
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1865 (7), 740-746, 2017
172017
Chemometric Strategies for Sensitive Annotation and Validation of Anatomical Regions of Interest in Complex Imaging Mass Spectrometry Data
PM Wehrli, W Michno, K Blennow, H Zetterberg, J Hanrieder
Journal of The American Society for Mass Spectrometry 30 (11), 2278-2288, 2019
142019
Refining the amyloid β peptide and oligomer fingerprint ambiguities in Alzheimer’s disease: Mass spectrometric molecular characterization in brain, cerebrospinal fluid, blood …
W Michno, K Blennow, H Zetterberg, G Brinkmalm
Journal of Neurochemistry 159 (2), 234-257, 2021
112021
Carnitine octanoyltransferase is important for the assimilation of exogenous acetyl-L-carnitine into acetyl-CoA in mammalian cells
J Hsu, N Fatuzzo, N Weng, W Michno, W Dong, M Kienle, Y Dai, A Pasca, ...
Journal of Biological Chemistry 299 (2), 2023
82023
Herpes simplex virus 1 and 2 infections during differentiation of human cortical neurons
P Bergström, E Trybala, CE Eriksson, M Johansson, TM Satir, S Widéhn, ...
Viruses 13 (10), 2072, 2021
82021
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