Wei Gu, Ph.D.
Wei Gu, Ph.D.
Abraham and Mildred Goldstein Professor at Columbia University
Verified email at - Homepage
Cited by
Cited by
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
W Gu, RG Roeder
Cell 90 (4), 595-606, 1997
Negative control of p53 by Sir2α promotes cell survival under stress
J Luo, AY Nikolaev, S Imai, D Chen, F Su, A Shiloh, L Guarente, W Gu
Cell 107 (2), 137-148, 2001
Ferroptosis as a p53-mediated activity during tumour suppression
L Jiang, N Kon, T Li, SJ Wang, T Su, H Hibshoosh, R Baer, W Gu
Nature 520 (7545), 57-62, 2015
Modes of p53 regulation
JP Kruse, W Gu
Cell 137 (4), 609-622, 2009
Mammalian SIRT1 represses forkhead transcription factors
MC Motta, N Divecha, M Lemieux, C Kamel, D Chen, W Gu, Y Bultsma, ...
Cell 116 (4), 551-563, 2004
CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy
W Wang, M Green, JE Choi, M Gijón, PD Kennedy, JK Johnson, P Liao, ...
Nature 569 (7755), 270-274, 2019
Ferroptosis as a target for protection against cardiomyopathy
X Fang, H Wang, D Han, E Xie, X Yang, J Wei, S Gu, F Gao, N Zhu, X Yin, ...
Proceedings of the National Academy of Sciences 116 (7), 2672-2680, 2019
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
M Li, D Chen, A Shiloh, J Luo, AY Nikolaev, J Qin, W Gu
Nature 416 (6881), 648-653, 2002
p53 ubiquitination: Mdm2 and beyond
CL Brooks, W Gu
Molecular cell 21 (3), 307-315, 2006
Deacetylation of p53 modulates its effect on cell growth and apoptosis
J Luo, F Su, D Chen, A Shiloh, W Gu
Nature 408 (6810), 377-381, 2000
Mono-versus polyubiquitination: differential control of p53 fate by Mdm2
M Li, CL Brooks, F Wu-Baer, D Chen, R Baer, W Gu
Science 302 (5652), 1972-1975, 2003
Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation
CL Brooks, W Gu
Current opinion in cell biology 15 (2), 164-171, 2003
Acetylation is indispensable for p53 activation
Y Tang, W Zhao, Y Chen, Y Zhao, W Gu
Cell 133 (4), 612-626, 2008
Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence
T Li, N Kon, L Jiang, M Tan, T Ludwig, Y Zhao, R Baer, W Gu
Cell 149 (6), 1269-1283, 2012
SIRT1 transgenic mice show phenotypes resembling calorie restriction
L Bordone, D Cohen, A Robinson, MC Motta, E Van Veen, A Czopik, ...
Aging cell 6 (6), 759-767, 2007
Synergistic activation of transcription by CBP and p53
W Gu, XL Shi, RG Roeder
Nature 387 (6635), 819-823, 1997
Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis
Y Tang, J Luo, W Zhang, W Gu
Molecular cell 24 (6), 827-839, 2006
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ
L Qiang, L Wang, N Kon, W Zhao, S Lee, Y Zhang, M Rosenbaum, Y Zhao, ...
Cell 150 (3), 620-632, 2012
A dynamic role of HAUSP in the p53-Mdm2 pathway
M Li, CL Brooks, N Kon, W Gu
Molecular cell 13 (6), 879-886, 2004
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
WY Chen, DH Wang, RWC Yen, J Luo, W Gu, SB Baylin
Cell 123 (3), 437-448, 2005
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