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Qi Zhang
Qi Zhang
Verified email at mdanderson.org
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Year
An inhibitor of oxidative phosphorylation exploits cancer vulnerability
JR Molina, Y Sun, M Protopopova, S Gera, M Bandi, C Bristow, T McAfoos, ...
Nature medicine 24 (7), 1036-1046, 2018
7172018
Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML
CD DiNardo, IS Tiong, A Quaglieri, S MacRaild, S Loghavi, FC Brown, ...
Blood, The Journal of the American Society of Hematology 135 (11), 791-803, 2020
4692020
A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity
S Khan, X Zhang, D Lv, Q Zhang, Y He, P Zhang, X Liu, D Thummuri, ...
Nature medicine 25 (12), 1938-1947, 2019
4022019
Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models
L Han, Q Zhang, M Dail, C Shi, A Cavazos, VR Ruvolo, Y Zhao, E Kim, ...
Haematologica 105 (3), 697, 2020
982020
Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials
TA Yap, N Daver, M Mahendra, J Zhang, C Kamiya-Matsuoka, ...
Nature medicine 29 (1), 115-126, 2023
922023
Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models
RS Mali, Q Zhang, RA DeFilippis, A Cavazos, VM Kuruvilla, J Raman, ...
Haematologica 106 (4), 1034, 2021
912021
Disruption of Wnt/β-catenin exerts antileukemia activity and synergizes with FLT3 inhibition in FLT3-mutant acute myeloid leukemia
X Jiang, PY Mak, H Mu, W Tao, DH Mak, S Kornblau, Q Zhang, P Ruvolo, ...
Clinical Cancer Research 24 (10), 2417-2429, 2018
792018
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity
D Lv, P Pal, X Liu, Y Jia, D Thummuri, P Zhang, W Hu, J Pei, Q Zhang, ...
Nature communications 12 (1), 6896, 2021
742021
Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia
Q Zhang, B Riley-Gillis, L Han, Y Jia, A Lodi, H Zhang, S Ganesan, R Pan, ...
Signal transduction and targeted therapy 7 (1), 51, 2022
702022
A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies
DC Phillips, S Jin, GP Gregory, Q Zhang, J Xue, X Zhao, J Chen, Y Tong, ...
Leukemia 34 (6), 1646-1657, 2020
622020
Regulation of PI3K signaling in T-cell acute lymphoblastic leukemia: a novel PTEN/Ikaros/miR-26b mechanism reveals a critical targetable role for PIK3CD
T Yuan, Y Yang, J Chen, W Li, Q Zhang, Y Mi, RS Goswami, JQ You, ...
Leukemia 31 (11), 2355-2364, 2017
602017
Inhibition of mTORC1/C2 signaling improves anti-leukemia efficacy of JAK/STAT blockade in CRLF2 rearranged and/or JAK driven Philadelphia chromosome–like acute B-cell …
Q Zhang, C Shi, L Han, N Jain, KG Roberts, H Ma, T Cai, A Cavazos, ...
Oncotarget 9 (8), 8027, 2018
482018
Antileukemia efficacy and mechanisms of action of SL-101, a novel anti-CD123 antibody conjugate, in acute myeloid leukemia
L Han, JL Jorgensen, C Brooks, C Shi, Q Zhang, GM Nogueras González, ...
Clinical Cancer Research 23 (13), 3385-3395, 2017
442017
Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition
K Saito, Q Zhang, H Yang, K Yamatani, T Ai, V Ruvolo, N Baran, T Cai, ...
Blood advances 5 (20), 4233-4255, 2021
422021
MLN0128, a novel mTOR kinase inhibitor, disrupts survival signaling and triggers apoptosis in AML and AML stem/progenitor cells
Z Zeng, RY Wang, YH Qiu, DH Mak, K Coombes, SY Yoo, Q Zhang, ...
Oncotarget 7 (34), 55083, 2016
342016
Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia
H Kuusanmäki, O Dufva, M Vähä-Koskela, AM Leppä, J Huuhtanen, ...
Blood 141 (13), 1610-1625, 2023
332023
Interim analysis of phase II study of venetoclax with 10-day decitabine (DEC10-VEN) in acute myeloid leukemia and myelodysplastic syndrome
A Maiti, CD DiNardo, JE Cortes, G Borthakur, N Pemmaraju, CB Benton, ...
Blood 132, 286, 2018
242018
Selective inhibition of the second bromodomain of BET family proteins results in robust antitumor activity in preclinical models of acute myeloid leukemia
L Zhang, T Cai, X Lin, X Huang, MH Bui, JP Plotnik, RJ Bellin, EJ Faivre, ...
Molecular cancer therapeutics 20 (10), 1809-1819, 2021
232021
Targeting CD123 in blastic plasmacytoid dendritic cell neoplasm using allogeneic anti-CD123 CAR T cells
T Cai, A Gouble, KL Black, A Skwarska, AS Naqvi, D Taylor, M Zhao, ...
Nature communications 13 (1), 2228, 2022
212022
Ten-day decitabine with venetoclax (DEC10-VEN) in acute myeloid leukemia: updated results of a phase II trial
A Maiti, CD DiNardo, CR Rausch, JE Cortes, N Pemmaraju, NG Daver, ...
Blood 134, 2637, 2019
212019
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