Bryce K. Allen
Bryce K. Allen
Silicon Therapeutics
Verifierad e-postadress på silicontx.com
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Relative binding free energy calculations in drug discovery: recent advances and practical considerations
Z Cournia, B Allen, W Sherman
Journal of chemical information and modeling 57 (12), 2911-2937, 2017
1552017
BET bromodomain proteins are required for glioblastoma cell proliferation
C Pastori, M Daniel, C Penas, CH Volmar, AL Johnstone, SP Brothers, ...
Epigenetics 9 (4), 611-620, 2014
992014
Data Portal for the Library of Integrated Network-based Cellular Signatures (LINCS) program: integrated access to diverse large-scale cellular perturbation response data
A Koleti, R Terryn, V Stathias, C Chung, DJ Cooper, JP Turner, D Vidović, ...
Nucleic acids research 46 (D1), D558-D566, 2018
732018
Large-scale computational screening identifies first in class multitarget inhibitor of EGFR kinase and BRD4
BK Allen, S Mehta, SWJ Ember, E Schonbrunn, N Ayad, SC Schürer
Scientific reports 5, 16924, 2015
412015
Epigenetic pathways and glioblastoma treatment: insights from signaling cascades
BK Allen, V Stathias, ME Maloof, D Vidovic, EF Winterbottom, ...
Journal of cellular biochemistry 116 (3), 351-363, 2015
142015
Identification of a novel class of BRD4 inhibitors by computational screening and binding simulations
BK Allen, S Mehta, SWJ Ember, JY Zhu, E Schönbrunn, NG Ayad, ...
ACS omega 2 (8), 4760-4771, 2017
132017
Rigorous free energy simulations in virtual screening
Z Cournia, BK Allen, T Beuming, DA Pearlman, BK Radak, W Sherman
Journal of Chemical Information and Modeling 60 (9), 4153-4169, 2020
102020
Comprehensive analysis of tissue-wide gene expression and phenotype data reveals tissues affected in rare genetic disorders
A Feiglin, BK Allen, IS Kohane, SW Kong
Cell systems 5 (2), 140-148. e2, 2017
82017
Improved Alchemical Free Energy Calculations with Optimized Smoothstep Softcore Potentials
TS Lee, Z Lin, BK Allen, C Lin, BK Radak, Y Tao, HC Tsai, W Sherman, ...
42020
Alchemical Binding Free Energy Calculations in AMBER20: Advances and Best Practices for Drug Discovery
TS Lee, BK Allen, TJ Giese, Z Guo, P Li, C Lin, TD McGee Jr, ...
Journal of Chemical Information and Modeling, 2020
32020
Kinome-wide activity classification of small molecules by deep learning
BK Allen, NG Ayad, SC Schürer
bioRxiv, 512459, 2018
22018
Oxoacridinyl acetic acid derivatives and methods of use
BT Chamberlain, JM Rice, FE JERNIGAN III, W Sherman, MM Kulkarni, ...
US Patent 10,745,358, 2020
12020
Best practices for alchemical free energy calculations
ASJS Mey, B Allen, HEB Macdonald, JD Chodera, M Kuhn, J Michel, ...
arXiv preprint arXiv:2008.03067, 2020
12020
Ligand-and structure-based virtual screening to discover dual EGFR and BRD4 inhibitors
B Allen, S Mehta, N Ayad, S Schürer
Cancer Research 75 (15 Supplement), 3690-3690, 2015
12015
DD-01LIGAND-AND STRUCTURE-BASED VIRTUAL SCREENING TO DISCOVER POLYPHARMACOLOGICAL DUAL EGFR AND BRD4 INHIBITORS
B Allen, S Mehta, N Ayad, S Schürer
Neuro-oncology 16 (Suppl 5), v60, 2014
12014
True small molecule STING agonist generates systemic and potent anti-tumor immunity required for effective cancer immunotherapy
MM Kulkarni, T Dwight, K Marino, BK Allen, M Taimi, C Bastos, S Lai, ...
MOLECULAR CANCER THERAPEUTICS 18 (12), 2019
2019
Abstract LB-A20: True small molecule STING agonist generates systemic and potent anti-tumor immunity required for effective cancer immunotherapy
MM Kulkarni, T Dwight, K Marino, BK Allen, M Taimi, C Bastos, S Lai, ...
Molecular Cancer Therapeutics 18 (12 Supplement), LB-A20-LB-A20, 2019
2019
Identification of therapeutic combinations in glioblastoma using personalized gene expression networks
V Stathias, M Forlin, B Allen, S Schürer, NG Ayad
Cancer Research 77 (13 Supplement), 416-416, 2017
2017
Large-scale Computational Screening and Machine Learning Approaches to Drug Discovery
BK Allen
University of Miami, 2016
2016
Combinatorial compound stratification based on integration of LINCS, TCGA and PubChem data
V Stathias, B Allen, J Clarke, NG Ayad, S Schürer
Cancer Research 76 (14 Supplement), 775-775, 2016
2016
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Artiklar 1–20