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Julia Fakhiri
Julia Fakhiri
Scientist
Verifierad e-postadress på roche.com
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Engineered anti-CRISPR proteins for optogenetic control of CRISPR–Cas9
F Bubeck, MD Hoffmann, Z Harteveld, S Aschenbrenner, A Bietz, ...
Nature methods 15 (11), 924-927, 2018
1962018
Cell-specific CRISPR–Cas9 activation by microRNA-dependent expression of anti-CRISPR proteins
MD Hoffmann, S Aschenbrenner, S Grosse, K Rapti, C Domenger, ...
Nucleic acids research 47 (13), e75-e75, 2019
942019
Relevance of assembly-activating protein for adeno-associated virus vector production and capsid protein stability in mammalian and insect cells
S Grosse, M Penaud-Budloo, AK Herrmann, K Börner, J Fakhiri, V Laketa, ...
Journal of virology 91 (20), 10.1128/jvi. 01198-17, 2017
752017
Pre-arrayed pan-AAV peptide display libraries for rapid single-round screening
K Börner, E Kienle, LY Huang, J Weinmann, A Sacher, P Bayer, C Stüllein, ...
Molecular therapy 28 (4), 1016-1032, 2020
522020
Novel chimeric gene therapy vectors based on adeno-associated virus and four different mammalian bocaviruses
J Fakhiri, MA Schneider, J Puschhof, M Stanifer, V Schildgen, ...
Molecular Therapy-Methods & Clinical Development 12, 202-222, 2019
472019
Ex vivo/in vivo gene editing in hepatocytes using “all-in-one” CRISPR-adeno-associated virus vectors with a self-linearizing repair template
SA Krooss, Z Dai, F Schmidt, A Rovai, J Fakhiri, A Dhingra, Q Yuan, ...
Iscience 23 (1), 2020
422020
Fantastic AAV gene therapy vectors and how to find them—random diversification, rational design and machine learning
J Becker, J Fakhiri, D Grimm
Pathogens 11 (7), 756, 2022
392022
Semirational bioengineering of AAV vectors with increased potency and specificity for systemic gene therapy of muscle disorders
J El Andari, E Renaud-Gabardos, W Tulalamba, J Weinmann, L Mangin, ...
Science advances 8 (38), eabn4704, 2022
302022
Best of most possible worlds: Hybrid gene therapy vectors based on parvoviruses and heterologous viruses
J Fakhiri, D Grimm
Molecular Therapy 29 (12), 3359-3382, 2021
182021
Rapid and simple screening of CRISPR guide RNAs (gRNAs) in cultured cells using adeno-associated viral (AAV) vectors
J Fakhiri, M Nickl, D Grimm
CRISPR Gene Editing: Methods and Protocols, 111-126, 2019
142019
Breaking the sound barrier: Towards next-generation AAV vectors for gene therapy of hearing disorders
J Fakhiri, LD Landegger, D Grimm
Hearing Research 413, 108092, 2022
122022
Impact of natural or synthetic singletons in the capsid of human bocavirus 1 on particle infectivity and immunoreactivity
J Fakhiri, KP Linse, M Mietzsch, M Xu, MA Schneider, M Meister, ...
Journal of Virology 94 (11), 10.1128/jvi. 00170-20, 2020
102020
Severe human bocavirus 1 respiratory tract infection in an immunodeficient child with fatal outcome
J Tabatabai, J Fakhiri, J Meyburg, KP Linse, M Xu, M Söderlund-Venermo, ...
The Pediatric Infectious Disease Journal 38 (9), e219-e222, 2019
92019
Characterization of the GBoV1 capsid and its antibody interactions
JC Yu, M Mietzsch, A Singh, A Jimenez Ybargollin, S Kailasan, ...
Viruses 13 (2), 330, 2021
62021
Means and methods for inactivating therapeutic dna in a cell
D Grimm, J Fakhiri
US Patent App. 16/094,788, 2019
42019
254. New Chimeric Gene Therapy Vectors Based on Four Different Mammalian Bocaviruses
J Fakhiri, M Schneider, S Kailasan, M Meister, MA McKenna, Z Yan, J Qiu, ...
Molecular Therapy 24, S100, 2016
32016
Novel assay format for total anti-adeno-associated virus antibody detection with low capsid consumption and built-in specificity control
U Wessels, F Neff, J Fakhiri, K Mayer, U Brinkmann, K Stubenrauch
Bioanalysis, 2024
2024
Peptide-displaying chimeric AAV vectors with increased skeletal muscle potency and liver detargeting for systemic gene therapy
E Renaud-Gabardos, J El Andari, L Mangin, J Weinmann, E Attebi, ...
Myology 2022, 2022
2022
Efficient Crossing of the Primate Bloodbrain Barrier by Adeno-Associated Virus Serotype 4 (AAV4)
O Maiakovska, JL Guo, F Bubeck, M Tiffany, J Becker, G Huber, ...
MOLECULAR THERAPY 30 (4), 242-242, 2022
2022
Modulated cas-inhibitors
D Niopek, R Eils, F Bubeck, D Grimm, MD Hoffmann, MC Waldhauer, ...
US Patent App. 16/756,887, 2021
2021
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