Sheo B Singh, PhD
Sheo B Singh, PhD
President, SBS Pharma Consulting
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Platensimycin is a selective FabF inhibitor with potent antibiotic properties
J Wang, SM Soisson, K Young, W Shoop, S Kodali, A Galgoci, R Painter, ...
Nature 441 (7091), 358-361, 2006
Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4
GR Pettit, SB Singh, E Hamel, CM Lin, DS Alberts, D Garcia-Kendal
Experientia 45 (2), 209-211, 1989
Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase
SJ Darkin-Rattray, AM Gurnett, RW Myers, PM Dulski, TM Crumley, ...
Proceedings of the National Academy of Sciences 93 (23), 13143-13147, 1996
Antineoplastic agents. 291. Isolation and synthesis of combretastatins A-4, A-5, and A-6
GR Pettit, SB Singh, MR Boyd, E Hamel, RK Pettit, JM Schmidt, F Hogan
Journal of medicinal chemistry 38 (10), 1666-1672, 1995
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties
J Wang, S Kodali, SH Lee, A Galgoci, R Painter, K Dorso, F Racine, ...
Proceedings of the National Academy of Sciences 104 (18), 7612-7616, 2007
Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study.
CM Lin, SB Singh, PS Chu, RO Dempcy, JM Schmidt, GR Pettit, E Hamel
Molecular pharmacology 34 (2), 200-208, 1988
Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrum
GR Pettit, SB Singh, ML Niven, E Hamel, JM Schmidt
Journal of natural products 50 (1), 119-131, 1987
Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo.
JB Gibbs, DL Pompliano, SD Mosser, E Rands, RB Lingham, SB Singh, ...
Journal of Biological Chemistry 268 (11), 7617-7620, 1993
Empirical antibacterial drug discovery—foundation in natural products
SB Singh, JF Barrett
Biochemical pharmacology 71 (7), 1006-1015, 2006
Isolation, structure, and absolute stereochemistry of platensimycin, a broad spectrum antibiotic discovered using an antisense differential sensitivity strategy
SB Singh, H Jayasuriya, JG Ondeyka, KB Herath, C Zhang, DL Zink, ...
Journal of the American Chemical Society 128 (36), 11916-11920, 2006
Antineoplastic agents. Part 189. The absolute configuration and synthesis of natural (-)-dolastatin 10
GR Pettit, SB Singh, F Hogan, P Lloyd-Williams, DL Herald, DD Burkett, ...
Journal of the American Chemical Society 111 (14), 5463-5465, 1989
Discovery of a small molecule that inhibits cell division by blocking FtsZ, a novel therapeutic target of antibiotics
J Wang, A Galgoci, S Kodali, KB Herath, H Jayasuriya, K Dorso, F Vicente, ...
Journal of Biological Chemistry 278 (45), 44424-44428, 2003
Discovery of FabH/FabF inhibitors from natural products
K Young, H Jayasuriya, JG Ondeyka, K Herath, C Zhang, S Kodali, ...
Antimicrobial agents and chemotherapy 50 (2), 519-526, 2006
Antineoplastic agents, 120. Pancratium littorale
GR Pettit, V Gaddamidi, DL Herald, SB Singh, GM Cragg, JM Schmidt, ...
Journal of natural products 49 (6), 995-1002, 1986
Isolation and structure of platencin: a FabH and FabF dual inhibitor with potent broad‐spectrum antibiotic activity
H Jayasuriya, KB Herath, C Zhang, DL Zink, A Basilio, O Genilloud, ...
Angewandte Chemie International Edition 46 (25), 4684-4688, 2007
Antineoplastic agents, 122. Constituents of Combretum caffrum
GR Pettit, GM Cragg, SB Singh
Journal of natural products 50 (3), 386-391, 1987
Equisetin and a novel opposite stereochemical homolog phomasetin, two fungal metabolites as inhibitors of HIV-1 integrase
SB Singh, DL Zink, MA Goetz, AW Dombrowski, JD Polishook, DJ Hazuda
Tetrahedron Letters 39 (16), 2243-2246, 1998
Nodulisporic Acid A, a Novel and Potent Insecticide from a Nodulisporium Sp. Isolation, Structure Determination, and Chemical Transformations
JG Ondeyka, GL Helms, OD Hensens, MA Goetz, DL Zink, A Tsipouras, ...
Journal of the American Chemical Society 119 (38), 8809-8816, 1997
A novel antiviral agent which inhibits the endonuclease of influenza viruses.
JE Tomassini, ME Davies, JC Hastings, R Lingham, M Mojena, ...
Antimicrobial agents and chemotherapy 40 (5), 1189-1193, 1996
Structure and chemistry of apicidins, a class of novel cyclic tetrapeptides without a terminal α-keto epoxide as inhibitors of histone deacetylase with potent antiprotozoal …
SB Singh, DL Zink, JM Liesch, RT Mosley, AW Dombrowski, GF Bills, ...
The Journal of Organic Chemistry 67 (3), 815-825, 2002
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