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Jay L. Hess
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MLL targets SET domain methyltransferase activity to Hox gene promoters
TA Milne, SD Briggs, HW Brock, ME Martin, D Gibbs, CD Allis, JL Hess
Molecular cell 10 (5), 1107-1117, 2002
12742002
Altered Hox expression and segmental identity in Mll-mutant mice
BD Yu, JL Hess, SE Horning, GAJ Brown, SJ Korsmeyer
Nature 378 (6556), 505-508, 1995
10541995
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
Y Dou, TA Milne, AJ Tackett, ER Smith, A Fukuda, J Wysocka, CD Allis, ...
Cell 121 (6), 873-885, 2005
7912005
Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus
CM Hughes, O Rozenblatt-Rosen, TA Milne, TD Copeland, SS Levine, ...
Molecular cell 13 (4), 587-597, 2004
7312004
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors
TA Milne, CM Hughes, R Lloyd, Z Yang, O Rozenblatt-Rosen, Y Dou, ...
Proceedings of the National Academy of Sciences 102 (3), 749-754, 2005
5352005
A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification
D Mueller, C Bach, D Zeisig, MP Garcia-Cuellar, S Monroe, A Sreekumar, ...
Blood, The Journal of the American Society of Hematology 110 (13), 4445-4454, 2007
4482007
MLL: a histone methyltransferase disrupted in leukemia
JL Hess
Trends in molecular medicine 10 (10), 500-507, 2004
4412004
Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
J Grembecka, S He, A Shi, T Purohit, AG Muntean, RJ Sorenson, ...
Nature chemical biology 8 (3), 277-284, 2012
4252012
MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis
BD Yu, RD Hanson, JL Hess, SE Horning, SJ Korsmeyer
Proceedings of the National Academy of Sciences 95 (18), 10632-10636, 1998
4121998
Hoxa9 and Meis1 Are Key Targets for MLL-ENL-Mediated Cellular Immortalization
BB Zeisig, T Milne, MP García-Cuéllar, S Schreiner, ME Martin, U Fuchs, ...
Molecular and cellular biology 24 (2), 617-628, 2004
3992004
The pathogenesis of mixed-lineage leukemia
AG Muntean, JL Hess
Annual Review of Pathology: Mechanisms of Disease 7, 283-301, 2012
3722012
Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo
D Borkin, S He, H Miao, K Kempinska, J Pollock, J Chase, T Purohit, ...
Cancer cell 27 (4), 589-602, 2015
3582015
Mammalian Trithorax and Polycomb-group homologues are antagonistic regulators of homeotic development
RD Hanson, JL Hess, BD Yu, P Ernst, M Van Lohuizen, A Berns, ...
Proceedings of the National Academy of Sciences 96 (25), 14372-14377, 1999
3351999
Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia
A Akalin, FE Garrett-Bakelman, M Kormaksson, J Busuttil, L Zhang, ...
PLoS genetics 8 (6), e1002781, 2012
3342012
Defects in Yolk Sac Hematopoiesis in Mll-Null Embryos
JL Hess, BD Yu, B Li, R Hanson, SJ Korsmeyer
Blood, The Journal of the American Society of Hematology 90 (5), 1799-1806, 1997
3341997
Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia
F Cao, EC Townsend, H Karatas, J Xu, L Li, S Lee, L Liu, Y Chen, ...
Molecular cell 53 (2), 247-261, 2014
3292014
MLL associates specifically with a subset of transcriptionally active target genes
TA Milne, Y Dou, ME Martin, HW Brock, RG Roeder, JL Hess
Proceedings of the National Academy of Sciences 102 (41), 14765-14770, 2005
2792005
The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis
AG Muntean, J Tan, K Sitwala, Y Huang, J Bronstein, JA Connelly, ...
Cancer cell 17 (6), 609-621, 2010
2682010
Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications
TA Milne, ME Martin, HW Brock, RK Slany, JL Hess
Cancer research 65 (24), 11367-11374, 2005
2322005
Identification and characterization of Hoxa9 binding sites in hematopoietic cells
Y Huang, K Sitwala, J Bronstein, D Sanders, M Dandekar, C Collins, ...
Blood, The Journal of the American Society of Hematology 119 (2), 388-398, 2012
2292012
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