| The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase T Gerken, CA Girard, YCL Tung, CJ Webby, V Saudek, KS Hewitson, ... Science 318 (5855), 1469-1472, 2007 | 1782 | 2007 |
| The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases R Chowdhury, KK Yeoh, YM Tian, L Hillringhaus, EA Bagg, NR Rose, ... EMBO reports 12 (5), 463-469, 2011 | 1104 | 2011 |
| Structural studies on 2-oxoglutarate oxygenases and related double-stranded β-helix fold proteins IJ Clifton, MA McDonough, D Ehrismann, NJ Kershaw, N Granatino, ... Journal of inorganic biochemistry 100 (4), 644-669, 2006 | 521 | 2006 |
| Inhibition of 2-oxoglutarate dependent oxygenases NR Rose, MA McDonough, ONF King, A Kawamura, CJ Schofield Chemical Society Reviews 40 (8), 4364-4397, 2011 | 419 | 2011 |
| Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2) MA McDonough, V Li, E Flashman, R Chowdhury, C Mohr, BMR Liénard, ... Proceedings of the National Academy of Sciences 103 (26), 9814-9819, 2006 | 402 | 2006 |
| Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity SS Ng, KL Kavanagh, MA McDonough, D Butler, ES Pilka, BMR Lienard, ... Nature 448 (7149), 87-91, 2007 | 347 | 2007 |
| Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α PJ Pollard, C Loenarz, DR Mole, MA McDonough, JM Gleadle, ... Biochemical Journal 416 (3), 387-394, 2008 | 336 | 2008 |
| Structural studies on human 2-oxoglutarate dependent oxygenases MA McDonough, C Loenarz, R Chowdhury, IJ Clifton, CJ Schofield Current opinion in structural biology 20 (6), 659-672, 2010 | 323 | 2010 |
| Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH) ME Cockman, DE Lancaster, IP Stolze, KS Hewitson, MA McDonough, ... Proceedings of the National Academy of Sciences 103 (40), 14767-14772, 2006 | 320 | 2006 |
| Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates KS Hewitson, BMR Liénard, MA McDonough, IJ Clifton, D Butler, ... Journal of Biological Chemistry 282 (5), 3293-3301, 2007 | 262 | 2007 |
| Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases NR Rose, SS Ng, J Mecinovic, BMR Liénard, SH Bello, Z Sun, ... Journal of medicinal chemistry 51 (22), 7053-7056, 2008 | 261 | 2008 |
| Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates J Brem, R Cain, S Cahill, MA McDonough, IJ Clifton, ... Nature communications 7 (1), 12406, 2016 | 250 | 2016 |
| Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor ML Coleman, MA McDonough, KS Hewitson, C Coles, J Mecinovicí, ... Journal of Biological Chemistry 282 (33), 24027-24038, 2007 | 250 | 2007 |
| Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases R Chowdhury, MA McDonough, J Mecinović, C Loenarz, E Flashman, ... Structure 17 (7), 981-989, 2009 | 248 | 2009 |
| The enzymes of β-lactam biosynthesis RB Hamed, JR Gomez-Castellanos, L Henry, C Ducho, MA McDonough, ... Natural product reports 30 (1), 21-107, 2013 | 234 | 2013 |
| Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases WS Aik, MA McDonough, A Thalhammer, R Chowdhury, CJ Schofield Current opinion in structural biology 22 (6), 691-700, 2012 | 206 | 2012 |
| Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation WS Aik, JS Scotti, H Choi, L Gong, M Demetriades, CJ Schofield, ... Nucleic acids research 42 (7), 4741-4754, 2014 | 188 | 2014 |
| Structural basis of metallo-β-lactamase inhibition by captopril stereoisomers J Brem, SS van Berkel, D Zollman, SY Lee, O Gileadi, PJ McHugh, ... Antimicrobial agents and chemotherapy 60 (1), 142-150, 2016 | 185 | 2016 |
| Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches NR Rose, ECY Woon, GL Kingham, ONF King, J Mecinovic, IJ Clifton, ... Journal of medicinal chemistry 53 (4), 1810-1818, 2010 | 179 | 2010 |
| 5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation RJ Hopkinson, A Tumber, C Yapp, R Chowdhury, WS Aik, KH Che, XS Li, ... Chemical science 4 (8), 3110-3117, 2013 | 174 | 2013 |
Wei Shen AikAssistant Professor, Hong Kong Baptist UniversityVerifierad e-postadress på hkbu.edu.hk
