β-Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE R Vassar, BD Bennett, S Babu-Khan, S Kahn, EA Mendiaz, P Denis, ... science 286 (5440), 735-741, 1999 | 5218 | 1999 |
Parkinson's disease-associated α-synuclein is more fibrillogenic than β-and γ-synuclein and cannot cross-seed its homologs AL Biere, SJ Wood, J Wypych, S Steavenson, Y Jiang, D Anafi, ... Journal of Biological Chemistry 275 (44), 34574-34579, 2000 | 258 | 2000 |
Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr T Dieckmann, ES Withers-Ward, MA Jarosinski, CF Liu, ISY Chen, ... nature structural biology 5 (12), 1042-1047, 1998 | 162 | 1998 |
Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2 P Ettmayer, D France, J Gounarides, M Jarosinski, MS Martin, ... Journal of medicinal chemistry 42 (6), 971-980, 1999 | 117 | 1999 |
Multiple behavioral effects of cocaine-and amphetamine-regulated transcript (CART) peptides in mice: CART 42–89 and CART 49–89 differ in potency and activity AW Bannon, J Seda, M Carmouche, JM Francis, MA Jarosinski, ... Journal of Pharmacology and Experimental Therapeutics 299 (3), 1021-1026, 2001 | 87 | 2001 |
Diastereospecific tandem Michael-like addition/electrophilic bromination: A one-pot tandem asymmetric synthesis of precursors of unusual amino acids G Li, MA Jarosinski, VJ Hruby Tetrahedron letters 34 (16), 2561-2564, 1993 | 85 | 1993 |
Enhanced resolution in MAS NMR for combinatorial chemistry MJ Shapiro, J Chin, RE Marti, MA Jarosinski Tetrahedron letters 38 (8), 1333-1336, 1997 | 76 | 1997 |
Characterization of the Stat5 protease C Lee, F Piazza, S Brutsaert, J Valens, I Strehlow, M Jarosinski, C Saris, ... Journal of Biological Chemistry 274 (38), 26767-26775, 1999 | 66 | 1999 |
‘Smart’insulin-delivery technologies and intrinsic glucose-responsive insulin analogues MA Jarosinski, B Dhayalan, N Rege, D Chatterjee, MA Weiss Diabetologia 64, 1016-1029, 2021 | 61 | 2021 |
Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo [Asp-Pro-dPhe-Arg-Trp-Lys]-NH2 C Fotsch, DM Smith, JA Adams, J Cheetham, M Croghan, EM Doherty, ... Bioorganic & medicinal chemistry letters 13 (14), 2337-2340, 2003 | 54 | 2003 |
HPLC/NMR in combinatorial chemistry J Chin, JB Fell, M Jarosinski, MJ Shapiro, JR Wareing Journal of organic chemistry 63, 386-390, 1998 | 52 | 1998 |
Proteinase-activated receptor-2 mediates hyperresponsiveness in isolated guinea pig bronchi VE Barrios, MA Jarosinski, CD Wright Biochemical pharmacology 66 (3), 519-525, 2003 | 47 | 2003 |
Asymmetric synthesis of unusual amino acids: An enantioselective synthesis of the four isomers of D-and LO-Methyl-2′, β-Dimethyltyrosine G Li, KC Russell, MA Jarosinski, VJ Hruby Tetrahedron letters 34 (16), 2565-2568, 1993 | 47 | 1993 |
Rational, computer-enabled peptide drug design: principles, methods, applications and future directions. 7(16), 2173-2193. J Diller, David J., Swanson, Jon., Bayden, Alexander S., Jarosinski, Mark A ... Future medicinal chemistry 7 (16), 2173-2193., 2015 | 44 | 2015 |
Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein P Kostenuik, C Gegg, M Jarosinski, O Kinstler US Patent App. 09/999,608, 2005 | 42 | 2005 |
Lanthionine macrocyclization by in situ activation of serine JP Mayer, J Zhang, S Groeger, CFA LIU, MA Jarosinski The Journal of peptide research 51 (6), 432-436, 1998 | 41 | 1998 |
Preparation of noncondensed 2-substituted 1-methylimidazoles via ipso substitution reaction on 2-sulfinyl or 2-sulfonyl derivatives of 4, 5-disubstituted 1-methylimidazoles MA Jarosinski, WK Anderson The Journal of Organic Chemistry 56 (12), 4058-4062, 1991 | 29 | 1991 |
Synthesis, chemical reactivity, and antitumor evaluation of congeners of carmethizole hydrochloride, an experimental acylated vinylogous carbinolamine tumor inhibitor MA Jarosinski, PS Reddy, WK Anderson Journal of medicinal chemistry 36 (23), 3618-3627, 1993 | 26 | 1993 |
Solid-Phase Synthesis via 5-Oxazolidinones. Ring-Opening Reactions with Amines and Reaction Monitoring by Single-Bead FT-IR Microspectroscopy RE Marti, B Yan, MA Jarosinski The Journal of Organic Chemistry 62 (16), 5615-5618, 1997 | 25 | 1997 |
Insertion of a synthetic switch into insulin provides metabolite-dependent regulation of hormone–receptor activation YS Chen, J Gleaton, Y Yang, B Dhayalan, NB Phillips, Y Liu, ... Proceedings of the National Academy of Sciences 118 (30), e2103518118, 2021 | 21 | 2021 |