| HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption I Papandreou, RA Cairns, L Fontana, AL Lim, NC Denko Cell metabolism 3 (3), 187-197, 2006 | 2551 | 2006 |
| Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma I Papandreou, NC Denko, M Olson, H Van Melckebeke, S Lust, A Tam, ... Blood, The Journal of the American Society of Hematology 117 (4), 1311-1314, 2011 | 526 | 2011 |
| Overcoming physiologic barriers to cancer treatment by molecularly targeting the tumor microenvironment R Cairns, I Papandreou, N Denko Molecular Cancer Research 4 (2), 61-70, 2006 | 429 | 2006 |
| Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L I Papandreou, AL Lim, K Laderoute, NC Denko Cell Death & Differentiation 15 (10), 1572-1581, 2008 | 401 | 2008 |
| Identification of a protein mediating respiratory supercomplex stability YC Chen, EB Taylor, N Dephoure, JM Heo, A Tonhato, I Papandreou, ... Cell metabolism 15 (3), 348-360, 2012 | 248 | 2012 |
| Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect Y Chen, R Cairns, I Papandreou, A Koong, NC Denko PloS one 4 (9), e7033, 2009 | 230 | 2009 |
| Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy RA Cairns, I Papandreou, PD Sutphin, NC Denko Proceedings of the National Academy of Sciences 104 (22), 9445-9450, 2007 | 208 | 2007 |
| Anticancer drugs that target metabolism: is dichloroacetate the new paradigm? I Papandreou, T Goliasova, NC Denko International journal of cancer 128 (5), 1001-1008, 2011 | 205 | 2011 |
| Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment I Papandreou, C Krishna, F Kaper, D Cai, AJ Giaccia, NC Denko Cancer research 65 (8), 3171-3178, 2005 | 149 | 2005 |
| HIF-1α in endurance training: suppression of oxidative metabolism SD Mason, H Rundqvist, I Papandreou, R Duh, WJ McNulty, RA Howlett, ... American Journal of Physiology-Regulatory, Integrative and Comparative …, 2007 | 146 | 2007 |
| Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism M Benej, X Hong, S Vibhute, S Scott, J Wu, E Graves, QT Le, AC Koong, ... Proceedings of the National Academy of Sciences 115 (42), 10756-10761, 2018 | 145 | 2018 |
| Cellular reaction to hypoxia: sensing and responding to an adverse environment I Papandreou, A Powell, AL Lim, N Denko Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 569 (1 …, 2005 | 106 | 2005 |
| Imaging the unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict tumor growth MT Spiotto, A Banh, I Papandreou, H Cao, MG Galvez, GC Gurtner, ... Cancer research 70 (1), 78-88, 2010 | 105 | 2010 |
| β-Catenin regulates hepatic mitochondrial function and energy balance in mice N Lehwald, GZ Tao, KY Jang, I Papandreou, B Liu, B Liu, MA Pysz, ... Gastroenterology 143 (3), 754-764, 2012 | 94 | 2012 |
| Tumor hypoxia blocks Wnt processing and secretion through the induction of endoplasmic reticulum stress M Verras, I Papandreou, AL Lim, NC Denko Molecular and cellular biology 28 (23), 7212-7224, 2008 | 88 | 2008 |
| 5′-AMP-activated protein kinase (AMPK) supports the growth of aggressive experimental human breast cancer tumors KR Laderoute, JM Calaoagan, W Chao, D Dinh, N Denko, S Duellman, ... Journal of Biological Chemistry 289 (33), 22850-22864, 2014 | 72 | 2014 |
| Microenvironmental control of glucose metabolism in tumors by regulation of pyruvate dehydrogenase T Golias, M Kery, S Radenkovic, I Papandreou International journal of cancer 144 (4), 674-686, 2019 | 64 | 2019 |
| HILPDA Regulates Lipid Metabolism, Lipid Droplet Abundance, and Response to Microenvironmental Stress in Solid Tumors MJ VandeKopple, J Wu, EN Auer, AJ Giaccia, NC Denko, I Papandreou Molecular Cancer Research 17 (10), 2089-2101, 2019 | 56 | 2019 |
| Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours T Golias, I Papandreou, R Sun, B Kumar, NV Brown, BJ Swanson, R Pai, ... Scientific reports 6 (1), 31146, 2016 | 53 | 2016 |
| ACSL3 regulates lipid droplet biogenesis and ferroptosis sensitivity in clear cell renal cell carcinoma TD Klasson, EL LaGory, H Zhao, SK Huynh, I Papandreou, EJ Moon, ... Cancer & Metabolism 10 (1), 14, 2022 | 35 | 2022 |
