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Louis De Muynck
Louis De Muynck
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Gain of toxicity from ALS/FTD-linked repeat expansions in C9ORF72 is alleviated by antisense oligonucleotides targeting GGGGCC-containing RNAs
J Jiang, Q Zhu, TF Gendron, S Saberi, M McAlonis-Downes, A Seelman, ...
Neuron 90 (3), 535-550, 2016
5492016
Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy
AS Laird, A Van Hoecke, L De Muynck, M Timmers, L Van Den Bosch, ...
PloS one 5 (10), e13368, 2010
1862010
Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo
S Beel, M Moisse, M Damme, L De Muynck, W Robberecht, ...
Human molecular genetics 26 (15), 2850-2863, 2017
1252017
Cellular effects of progranulin in health and disease
L De Muynck, P Van Damme
Journal of Molecular Neuroscience 45, 549-560, 2011
1202011
The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding
L De Muynck, S Herdewyn, S Beel, W Scheveneels, L Van Den Bosch, ...
Neurobiology of aging 34 (11), 2541-2547, 2013
902013
Microglial upregulation of progranulin as a marker of motor neuron degeneration
T Philips, L De Muynck, H Nguyen Thi Thu, B Weynants, P Vanacker, ...
Journal of Neuropathology & Experimental Neurology 69 (12), 1191-1200, 2010
862010
Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia
S Raitano, L Ordovàs, L De Muynck, W Guo, I Espuny-Camacho, ...
Stem cell reports 4 (1), 16-24, 2015
782015
RNA sequencing analysis of intracranial aneurysm walls reveals involvement of lysosomes and immunoglobulins in rupture
R Kleinloog, BH Verweij, P Van Der Vlies, P Deelen, MA Swertz, ...
Stroke 47 (5), 1286-1293, 2016
672016
Genetically engineered iPSC-derived FTDP-17 MAPT neurons display mutation-specific neurodegenerative and neurodevelopmental phenotypes
A Verheyen, A Diels, J Reumers, K Van Hoorde, I Van den Wyngaert, ...
Stem cell reports 11 (2), 363-379, 2018
552018
Immunologic profiles of multiple sclerosis treatments reveal shared early B cell alterations
J Dooley, I Pauwels, D Franckaert, I Smets, JE Garcia-Perez, K Hilven, ...
Neuroimmunology & Neuroinflammation 3 (4), e240, 2016
512016
Differentially expressed genes in Alzheimer’s disease highlighting the roles of microglia genes including OLR1 and astrocyte gene CDK2AP1
QS Li, L De Muynck
Brain, Behavior, & Immunity-Health 13, 100227, 2021
312021
RNA-sequencing highlights inflammation and impaired integrity of the vascular wall in brain arteriovenous malformations
AJ Hauer, R Kleinloog, F Giuliani, GJE Rinkel, GA de Kort, ...
Stroke 51 (1), 268-274, 2020
232020
PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding
AC Soares, A Ferreira, J Mariën, C Delay, E Lee, JQ Trojanowski, ...
Journal of Biological Chemistry 296, 2021
212021
Progranulin does not affect motor neuron degeneration in mutant SOD1 mice and rats
S Herdewyn, L De Muynck, L Van Den Bosch, W Robberecht, ...
Neurobiology of aging 34 (10), 2302-2303, 2013
112013
Absence of uptake and prion-like spreading of alpha-synuclein and tau after intravitreal injection of preformed fibrils
L Veys, J Van Houcke, J Aerts, S Van Pottelberge, M Mahieu, A Coens, ...
Frontiers in Aging Neuroscience 12, 614587, 2021
82021
The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates
A Ferreira, I Royaux, J Liu, Z Wang, G Su, D Moechars, N Callewaert, ...
BMC Molecular and Cell Biology 23 (1), 61, 2022
42022
Protein interactors of 3-O sulfated heparan sulfates in human MCI and age-matched control cerebrospinal fluid
A Ferreira, E Timmerman, A Staes, M Vuylsteke, L De Muynck, K Gevaert
Scientific Data 10 (1), 121, 2023
22023
Characterization of APOE Christchurch carriers in 455,306 UK Biobank participants
KY He, EA Khramtsova, A Cabrera-Socorro, Y Zhang, S Li, BAJ Sarver, ...
Molecular Neurodegeneration 18 (1), 92, 2023
12023
The development of drug therapies for frontotemporal dementia caused by progranulin mutations
L De Muynck, P Van Damme
Atta-ur-Rahman, editor. Frontiers in clinical drug research-Alzheimer …, 2015
12015
Peripheral progranulin levels do not reflect brain progranulin levels
LD Muynck, PV Damme
Future Neurology 9 (5), 521-524, 2014
12014
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Artiklar 1–20