Sylvain E. Lesné, PhD
Sylvain E. Lesné, PhD
Associate Professor of Neuroscience, University of Minnesota
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A specific amyloid-β protein assembly in the brain impairs memory
S Lesné, MT Koh, L Kotilinek, R Kayed, CG Glabe, A Yang, M Gallagher, ...
Nature 440 (7082), 352-357, 2006
Accelerating amyloid-β fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models
IH Cheng, K Scearce-Levie, J Legleiter, JJ Palop, H Gerstein, N Bien-Ly, ...
Journal of Biological Chemistry 282 (33), 23818-23828, 2007
Brain amyloid-β oligomers in ageing and Alzheimer’s disease
SE Lesne, MA Sherman, M Grant, M Kuskowski, JA Schneider, ...
Brain 136 (5), 1383-1398, 2013
Soluble Aβ oligomer production and toxicity
ME Larson, SE Lesné
Journal of neurochemistry 120, 125-139, 2012
Ischemia-induced interleukin-6 as a potential endogenous neuroprotective cytokine against NMDA receptor-mediated excitoxicity in the brain
C Ali, O Nicole, F Docagne, S Lesne, ET MacKenzie, A Nouvelot, ...
Journal of Cerebral Blood Flow & Metabolism 20 (6), 956-966, 2000
The complex PrPc-Fyn couples human oligomeric Aβ with pathological Tau changes in Alzheimer's disease
M Larson, MA Sherman, F Amar, M Nuvolone, JA Schneider, DA Bennett, ...
Journal of Neuroscience 32 (47), 16857-16871, 2012
Cyclooxygenase-2 inhibition improves amyloid-β-mediated suppression of memory and synaptic plasticity
LA Kotilinek, MA Westerman, Q Wang, K Panizzon, GP Lim, A Simonyi, ...
Brain 131 (3), 651-664, 2008
NMDA receptor activation inhibits α-secretase and promotes neuronal amyloid-β production
S Lesné, C Ali, C Gabriel, N Croci, ET MacKenzie, CG Glabe, M Plotkine, ...
Journal of Neuroscience 25 (41), 9367-9377, 2005
Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory function
S Lesné, L Kotilinek, KH Ashe
Neuroscience 151 (3), 745-749, 2008
Orally available compound prevents deficits in memory caused by the Alzheimer amyloid‐β oligomers
M Townsend, JP Cleary, T Mehta, J Hofmeister, S Lesne, E O'Hare, ...
Annals of Neurology: Official Journal of the American Neurological …, 2006
Cognitive effects of cell-derived and synthetically derived Aβ oligomers
MN Reed, JJ Hofmeister, L Jungbauer, AT Welzel, C Yu, MA Sherman, ...
Neurobiology of aging 32 (10), 1784-1794, 2011
Involvement of β-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity
H Ma, S Lesné, L Kotilinek, JV Steidl-Nichols, M Sherman, L Younkin, ...
Proceedings of the National Academy of Sciences 104 (19), 8167-8172, 2007
Transforming growth factor-β1 potentiates amyloid-β generation in astrocytes and in transgenic mice
S Lesné, F Docagne, C Gabriel, G Liot, DK Lahiri, L Buée, L Plawinski, ...
Journal of Biological Chemistry 278 (20), 18408-18418, 2003
Angiopoietin‐1‐induced phosphatidyl‐inositol 3‐kinase activation prevents neuronal apoptosis
S Valable, A Bellail, S Lesne, G Liot, ET Mackenzie, D Vivien, ...
The FASEB journal 17 (3), 1-19, 2003
Transforming growth factor-β and ischemic brain injury
A Buisson, S Lesne, F Docagne, C Ali, O Nicole, ET MacKenzie, D Vivien
Cellular and molecular neurobiology 23 (4-5), 539-550, 2003
β-amyloid modulation of synaptic transmission and plasticity
DV Venkitaramani, J Chin, WJ Netzer, GK Gouras, S Lesne, R Malinow, ...
Journal of Neuroscience 27 (44), 11832-11837, 2007
Soluble α-synuclein is a novel modulator of Alzheimer's disease pathophysiology
ME Larson, MA Sherman, S Greimel, M Kuskowski, JA Schneider, ...
Journal of Neuroscience 32 (30), 10253-10266, 2012
Oligomers of the amyloid-β protein disrupt working memory: confirmation with two behavioral procedures
A Poling, K Morgan-Paisley, JJ Panos, EM Kim, E O’Hare, JP Cleary, ...
Behavioural brain research 193 (2), 230-234, 2008
Smad3-dependent induction of plasminogen activator inhibitor-1 in astrocytes mediates neuroprotective activity of transforming growth factor-β1 against NMDA-induced necrosis
F Docagne, O Nicole, C Gabriel, M Fernández-Monreal, S Lesné, C Ali, ...
Molecular and Cellular Neuroscience 21 (4), 634-644, 2002
Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease
SW Fowler, ACA Chiang, RR Savjani, ME Larson, MA Sherman, ...
Journal of Neuroscience 34 (23), 7871-7885, 2014
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