| Comprehensive characterization of cancer driver genes and mutations MH Bailey, C Tokheim, E Porta-Pardo, S Sengupta, D Bertrand, ... Cell 173 (2), 371-385. e18, 2018 | 2146 | 2018 |
| The genomic landscape of response to EGFR blockade in colorectal cancer A Bertotti, E Papp, S Jones, V Adleff, V Anagnostou, B Lupo, M Sausen, ... Nature 526 (7572), 263-267, 2015 | 456 | 2015 |
| Evaluating the evaluation of cancer driver genes CJ Tokheim, N Papadopoulos, KW Kinzler, B Vogelstein, R Karchin Proceedings of the National Academy of Sciences 113 (50), 14330-14335, 2016 | 369 | 2016 |
| Perspective on oncogenic processes at the end of the beginning of cancer genomics L Ding, MH Bailey, E Porta-Pardo, V Thorsson, A Colaprico, D Bertrand, ... Cell 173 (2), 305-320. e10, 2018 | 355 | 2018 |
| Minimal functional driver gene heterogeneity among untreated metastases JG Reiter, AP Makohon-Moore, JM Gerold, A Heyde, MA Attiyeh, ... Science 361 (6406), 1033-1037, 2018 | 272 | 2018 |
| Systematic functional annotation of somatic mutations in cancer PKS Ng, J Li, KJ Jeong, S Shao, H Chen, YH Tsang, S Sengupta, Z Wang, ... Cancer cell 33 (3), 450-462. e10, 2018 | 245 | 2018 |
| Genomic alterations in head and neck squamous cell carcinoma determined by cancer gene-targeted sequencing CH Chung, VB Guthrie, DL Masica, C Tokheim, H Kang, J Richmon, ... Annals of oncology 26 (6), 1216-1223, 2015 | 191 | 2015 |
| A pan-cancer analysis reveals high-frequency genetic alterations in mediators of signaling by the TGF-β superfamily A Korkut, S Zaidi, RS Kanchi, S Rao, NR Gough, A Schultz, X Li, ... Cell systems 7 (4), 422-437. e7, 2018 | 143 | 2018 |
| Exome-scale discovery of hotspot mutation regions in human cancer using 3D protein structure C Tokheim, R Bhattacharya, N Niknafs, DM Gygax, R Kim, M Ryan, ... Cancer research 76 (13), 3719-3731, 2016 | 138 | 2016 |
| High-throughput prediction of MHC class I and II neoantigens with MHCnuggets XM Shao, R Bhattacharya, J Huang, IKA Sivakumar, C Tokheim, L Zheng, ... Cancer immunology research 8 (3), 396-408, 2020 | 117 | 2020 |
| Therapeutically increasing MHC-I expression potentiates immune checkpoint blockade SS Gu, W Zhang, X Wang, P Jiang, N Traugh, Z Li, C Meyer, B Stewig, ... Cancer discovery 11 (6), 1524-1541, 2021 | 110 | 2021 |
| CHASMplus reveals the scope of somatic missense mutations driving human cancers C Tokheim, R Karchin Cell systems 9 (1), 9-23. e8, 2019 | 97 | 2019 |
| In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target X Wang, C Tokheim, SS Gu, B Wang, Q Tang, Y Li, N Traugh, Z Zeng, ... Cell 184 (21), 5357-5374. e22, 2021 | 89 | 2021 |
| Whole-genome sequencing of salivary gland adenoid cystic carcinoma EM Rettig, CC Talbot Jr, M Sausen, S Jones, JA Bishop, LD Wood, ... Cancer Prevention Research 9 (4), 265-274, 2016 | 89 | 2016 |
| Identifying differential alternative splicing events from RNA sequencing data using RNASeq-MATS JW Park, C Tokheim, S Shen, Y Xing Deep sequencing data analysis, 171-179, 2013 | 77 | 2013 |
| Integrated informatics analysis of cancer-related variants KA Pagel, R Kim, K Moad, B Busby, L Zheng, C Tokheim, M Ryan, ... JCO clinical cancer informatics 4, 310-317, 2020 | 74 | 2020 |
| Transcriptome-wide landscape of pre-mRNA alternative splicing associated with metastatic colonization Z Lu, Q Huang, JW Park, S Shen, L Lin, CJ Tokheim, MD Henry, Y Xing Molecular Cancer Research 13 (2), 305-318, 2015 | 71 | 2015 |
| CRAVAT 4: cancer-related analysis of variants toolkit DL Masica, C Douville, C Tokheim, R Bhattacharya, RG Kim, K Moad, ... Cancer research 77 (21), e35-e38, 2017 | 60 | 2017 |
| Determinants of transcription factor regulatory range CH Chen, R Zheng, C Tokheim, X Dong, J Fan, C Wan, Q Tang, M Brown, ... Nature communications 11 (1), 2472, 2020 | 44 | 2020 |
| Systematic characterization of mutations altering protein degradation in human cancers C Tokheim, X Wang, RT Timms, B Zhang, EL Mena, B Wang, C Chen, ... Molecular cell 81 (6), 1292-1308. e11, 2021 | 41 | 2021 |
Rachel KarchinProfessor of Biomedical Engineering, Oncology and Computer Science, Johns Hopkins UniversityVerified email at jhu.edu
