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James B Stewart
James B Stewart
Biosciences Institute, Faculty of Medical Sciences, Newcastle University
Verifierad e-postadress på newcastle.ac.uk - Startsida
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The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease
JB Stewart, PF Chinnery
Nature Reviews Genetics 16 (9), 530-542, 2015
8862015
Incorporating molecular evolution into phylogenetic analysis, and a new compilation of conserved polymerase chain reaction primers for animal mitochondrial DNA
C Simon, TR Buckley, F Frati, JB Stewart, AT Beckenbach
Annu. Rev. Ecol. Evol. Syst. 37, 545-579, 2006
6852006
Strong purifying selection in transmission of mammalian mitochondrial DNA
JB Stewart, C Freyer, JL Elson, A Wredenberg, Z Cansu, A Trifunovic, ...
PLoS biology 6 (1), e10, 2008
5252008
LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs
B Ruzzenente, MD Metodiev, A Wredenberg, A Bratic, CB Park, Y Cámara, ...
The EMBO Journal, 2011
3422011
Germline mitochondrial DNA mutations aggravate ageing and can impair brain development
JM Ross, JB Stewart, E Hagström, S Brené, A Mourier, C Freyer, ...
Nature 501, 412–415, 2013
2912013
Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins
A Ameur, JB Stewart, C Freyer, E Hagström, M Ingman, NG Larsson, ...
PLoS Genetics 7 (3), e1002028, 2011
2612011
Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo
PA Gammage, C Viscomi, ML Simard, ASH Costa, E Gaude, CA Powell, ...
Nature Medicine 24 (11), 1691-1695, 2018
2592018
MitoTALEN reduces mutant mtDNA load and restores tRNA Ala levels in a mouse model of heteroplasmic mtDNA mutation
SR Bacman, JHK Kauppila, CV Pereira, N Nissanka, M Miranda, M Pinto, ...
Nature Medicine 24 (11), 1696-1700, 2018
2362018
Purifying selection of mtDNA and its implications for understanding evolution and mitochondrial disease
JB Stewart, C Freyer, JL Elson, NG Larsson
Nature Reviews Genetics 9 (9), 657-662, 2008
2102008
Extreme heterogeneity of human mitochondrial DNA from organelles to populations
JB Stewart, PF Chinnery
Nature Reviews Genetics, https://doi.org/10.1038/s41576-020-00284, 2020
1622020
MTERF1 Binds mtDNA to Prevent Transcriptional Interference at the Light-Strand Promoter but Is Dispensable for rRNA Gene Transcription Regulation
M Terzioglu, B Ruzzenente, J Harmel, A Mourier, E Jemt, MD Lopez, ...
Cell Metabolism 17 (4), 618-626, 2013
1542013
Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission
C Freyer, LM Cree, A Mourier, JB Stewart, C Koolmeister, D Milenkovic, ...
Nature Genetics 44 (11), 1282, 2012
1392012
Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly
O Rackham, JD Busch, S Matic, SJ Siira, I Kuznetsova, I Atanassov, ...
Cell Reports 16 (7), 1874-1890, 2016
1352016
Simultaneous DNA and RNA Mapping of Somatic Mitochondrial Mutations across Diverse Human Cancers
JB Stewart, B Alaei-Mahabadi, R Sabarinathan, T Samuelsson, ...
PLoS Genetics 11 (6), e1005333, 2015
1252015
No recombination of mtDNA after 50 generations in the mouse maternal germline.
E Hagström, C Freyer, B Battersby, JB Stewart, NG Larsson
Nucleic Acids Research 42 (2), 1111-1116, 2014
124*2014
Keeping mtDNA in Shape between Generations
JB Stewart, NG Larsson
PLoS Genetics 10 (10), e1004670, 2014
1212014
Insect mitochondrial genomics: the complete mitochondrial genome sequence of the meadow spittlebug Philaenus spumarius (Hemiptera: Auchenorrhyncha: Cercopoidae)
JB Stewart, AT Beckenbach
Genome 48 (1), 46-54, 2005
1182005
Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice
X Zhou, N Solaroli, M Bjerke, JB Stewart, B Rozell, M Johansson, ...
Human molecular genetics 17 (15), 2329, 2008
1152008
A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease
JHK Kauppila, HL Baines, A Bratic, ML Simard, C Freyer, A Mourier, ...
Cell Reports 16 (11), 2980–2990, 2016
1142016
Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse
R Filograna, C Koolmeister, M Upadhyay, A Pajak, P Clemente, R Wibom, ...
Science Advances 5 (4), eaav9824, 2019
1112019
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