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David W. Colby
David W. Colby
Assistant Professor, University of Delaware
Verifierad e-postadress på udel.edu - Startsida
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Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library
MJ Feldhaus, RW Siegel, LK Opresko, JR Coleman, JMW Feldhaus, ...
Nature biotechnology 21 (2), 163-170, 2003
6632003
Prions
DW Colby, SB Prusiner
Cold Spring Harbor perspectives in biology 3 (1), a006833, 2011
6242011
Small-molecule aggregates inhibit amyloid polymerization
BY Feng, BH Toyama, H Wille, DW Colby, SR Collins, BCH May, ...
Nature chemical biology 4 (3), 197-199, 2008
3032008
Prion detection by an amyloid seeding assay
DW Colby, Q Zhang, S Wang, D Groth, G Legname, D Riesner, ...
Proceedings of the National Academy of Sciences 104 (52), 20914-20919, 2007
2712007
Natural and synthetic prion structure from X-ray fiber diffraction
H Wille, W Bian, M McDonald, A Kendall, DW Colby, L Bloch, J Ollesch, ...
Proceedings of the National Academy of Sciences 106 (40), 16990-16995, 2009
2672009
Design and construction of diverse mammalian prion strains
DW Colby, K Giles, G Legname, H Wille, IV Baskakov, SJ DeArmond, ...
Proceedings of the National Academy of Sciences 106 (48), 20417-20422, 2009
2492009
Inert and seed-competent tau monomers suggest structural origins of aggregation
H Mirbaha, D Chen, OA Morazova, KM Ruff, AM Sharma, X Liu, ...
Elife 7, e36584, 2018
2382018
Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody
DW Colby, YJ Chu, JP Cassady, M Duennwald, H Zazulak, JM Webster, ...
Proceedings of the National Academy of Sciences 101 (51), 17616-17621, 2004
2352004
Engineering antibody affinity by yeast surface display
DW Colby, BA Kellogg, CP Graff, YA Yeung, JS Swers, KD Wittrup
Methods in enzymology 388, 348-358, 2004
2062004
Protease-sensitive synthetic prions
DW Colby, R Wain, IV Baskakov, G Legname, CG Palmer, HOB Nguyen, ...
PLoS pathogens 6 (1), e1000736, 2010
1972010
Development of a human light chain variable domain (VL) intracellular antibody specific for the amino terminus of huntingtin via yeast surface display
DW Colby, P Garg, T Holden, G Chao, JM Webster, A Messer, VM Ingram, ...
Journal of molecular biology 342 (3), 901-912, 2004
1362004
De novo generation of prion strains
DW Colby, SB Prusiner
Nature Reviews Microbiology 9 (11), 771-777, 2011
1072011
Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease
BA Barbaro, T Lukacsovich, N Agrawal, J Burke, DJ Bornemann, ...
Human molecular genetics 24 (4), 913-925, 2015
1022015
Conformational features of tau fibrils from Alzheimer’s disease brain are faithfully propagated by unmodified recombinant protein
OA Morozova, ZM March, AS Robinson, DW Colby
Biochemistry 52 (40), 6960-6967, 2013
972013
Stochastic kinetics of intracellular huntingtin aggregate formation
DW Colby, JP Cassady, GC Lin, VM Ingram, KD Wittrup
Nature Chemical Biology 2 (6), 319-323, 2006
822006
The N-terminus of the prion protein is a toxic effector regulated by the C-terminus
B Wu, AJ McDonald, K Markham, CB Rich, KP McHugh, J Tatzelt, ...
Elife 6, e23473, 2017
722017
Conformation-dependent epitopes recognized by prion protein antibodies probed using mutational scanning and deep sequencing
KM Doolan, DW Colby
Journal of molecular biology 427 (2), 328-340, 2015
612015
Convergent replication of mouse synthetic prion strains
S Ghaemmaghami, DW Colby, HOB Nguyen, S Hayashi, A Oehler, ...
The American journal of pathology 182 (3), 866-874, 2013
422013
Protein misfolding detected early in pathogenesis of transgenic mouse model of Huntington disease using amyloid seeding assay
S Gupta, DW Colby
Journal of Biological Chemistry 287 (13), 9982-9989, 2012
402012
A disulfide-free single-domain VL intrabody with blocking activity towards huntingtin reveals a novel mode of epitope recognition
A Schiefner, L Chatwell, J Körner, I Neumaier, DW Colby, R Volkmer, ...
Journal of molecular biology 414 (3), 337-355, 2011
392011
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Artiklar 1–20