Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. J Chen, X Zheng, EJ Brown, SL Schreiber Proceedings of the National Academy of Sciences 92 (11), 4947-4951, 1995 | 801 | 1995 |
Targeting mammalian target of rapamycin (mTOR) for health and diseases CK Tsang, H Qi, LF Liu, XFS Zheng Drug discovery today 12 (3-4), 112-124, 2007 | 552 | 2007 |
Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance CK Tsang, Y Liu, J Thomas, Y Zhang, XFS Zheng Nature communications 5 (1), 3446, 2014 | 456 | 2014 |
TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin XF Zheng, D Fiorentino, J Chen, GR Crabtree, SL Schreiber Cell 82 (1), 121-130, 1995 | 373 | 1995 |
Tripartite regulation of Gln3p by TOR, Ure2p, and phosphatases PG Bertram, JH Choi, J Carvalho, W Ai, C Zeng, TF Chan, XFS Zheng Journal of Biological Chemistry 275 (46), 35727-35733, 2000 | 294 | 2000 |
Nutrient regulates Tor1 nuclear localization and association with rDNA promoter H Li, CK Tsang, M Watkins, PG Bertram, XFS Zheng Nature 442 (7106), 1058-1061, 2006 | 280 | 2006 |
Rab1A is an mTORC1 activator and a colorectal oncogene JD Thomas, YJ Zhang, YH Wei, JH Cho, LE Morris, HY Wang, XFS Zheng Cancer cell 26 (5), 754-769, 2014 | 269 | 2014 |
Expanding roles of superoxide dismutases in cell regulation and cancer M Che, R Wang, X Li, HY Wang, XFS Zheng Drug discovery today 21 (1), 143-149, 2016 | 268 | 2016 |
Targeting the mTOR kinase domain: the second generation of mTOR inhibitors YJ Zhang, Y Duan, XFS Zheng Drug discovery today 16 (7-8), 325-331, 2011 | 226 | 2011 |
FKBP12-rapamycin-associated protein or mammalian target of rapamycin (FRAP/mTOR) localization in the endoplasmic reticulum and the Golgi apparatus RM Drenan, X Liu, PG Bertram, XFS Zheng Journal of Biological Chemistry 279 (1), 772-778, 2004 | 213 | 2004 |
A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR) TF Chan, J Carvalho, L Riles, XFS Zheng Proceedings of the National Academy of Sciences 97 (24), 13227-13232, 2000 | 206 | 2000 |
Chromatin-mediated regulation of nucleolar structure and RNA Pol I localization by TOR CK Tsang, PG Bertram, W Ai, R Drenan, XFS Zheng The EMBO journal 22 (22), 6045-6056, 2003 | 203 | 2003 |
mTOR binds to the promoters of RNA polymerase I-and III-transcribed genes CK Tsang, H Liu, XFS Zheng Cell Cycle 9 (5), 953-957, 2010 | 192 | 2010 |
Mechanisms of regulation of RNA polymerase III‐dependent transcription by TORC1 Y Wei, CK Tsang, XFS Zheng The EMBO journal 28 (15), 2220-2230, 2009 | 191 | 2009 |
Regulation of subtelomeric silencing during stress response W Ai, PG Bertram, CK Tsang, TF Chan, XFS Zheng Molecular cell 10 (6), 1295-1305, 2002 | 169 | 2002 |
Convergence of TOR-nitrogen and Snf1-glucose signaling pathways onto Gln3 PG Bertram, JH Choi, J Carvalho, TF Chan, W Ai, XFS Zheng Molecular and cellular biology 22 (4), 1246-1252, 2002 | 157 | 2002 |
Toward rapamycin analog (rapalog)-based precision cancer therapy L Meng, XF Zheng Acta Pharmacologica Sinica 36 (10), 1163-1169, 2015 | 131 | 2015 |
The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase JH Choi, PG Bertram, R Drenan, J Carvalho, HH Zhou, XFS Zheng EMBO reports 3 (10), 988-994, 2002 | 129 | 2002 |
The 14-3-3 proteins positively regulate rapamycin-sensitive signaling PG Bertram, C Zeng, J Thorson, AS Shaw, XFS Zheng Current biology 8 (23), S1, 1998 | 128 | 1998 |
Endoplasmic reticulum and Golgi localization sequences for mammalian target of rapamycin X Liu, XFS Zheng Molecular biology of the cell 18 (3), 1073-1082, 2007 | 126 | 2007 |