John LaCava
John LaCava
Group Leader, The European Research Institute for the Biology of Ageing (ERIBA)
Verified email at - Homepage
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RNA degradation by the exosome is promoted by a nuclear polyadenylation complex
J LaCava, J Houseley, C Saveanu, E Petfalski, E Thompson, A Jacquier, ...
Cell 121 (5), 713-724, 2005
RNA-quality control by the exosome
J Houseley, J LaCava, D Tollervey
Nature reviews Molecular cell biology 7 (7), 529-539, 2006
Affinity proteomics reveals human host factors implicated in discrete stages of LINE-1 retrotransposition
MS Taylor, J LaCava, P Mita, KR Molloy, CRL Huang, D Li, EM Adney, ...
Cell 155 (5), 1034-1048, 2013
The human cap-binding complex is functionally connected to the nuclear RNA exosome
PR Andersen, M Domanski, MS Kristiansen, H Storvall, E Ntini, ...
Nature structural & molecular biology 20 (12), 1367-1376, 2013
Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms
HL Chan, F Beckedorff, Y Zhang, J Garcia-Huidobro, H Jiang, A Colaprico, ...
Nature communications 9 (1), 3377, 2018
LINE-1 protein localization and functional dynamics during the cell cycle
P Mita, A Wudzinska, X Sun, J Andrade, S Nayak, DJ Kahler, S Badri, ...
Elife 7, e30058, 2018
Rapid, optimized interactomic screening
Z Hakhverdyan, M Domanski, LE Hough, AA Oroskar, AR Oroskar, ...
Nature methods 12 (6), 553-560, 2015
Dissection of affinity captured LINE-1 macromolecular complexes
MS Taylor, I Altukhov, KR Molloy, P Mita, H Jiang, EM Adney, ...
elife 7, e30094, 2018
Improved methodology for the affinity isolation of human protein complexes expressed at near endogenous levels
M Domanski, K Molloy, H Jiang, BT Chait, MP Rout, TH Jensen, J LaCava
Biotechniques, 1, 2012
Targeting the CALR interactome in myeloproliferative neoplasms
E Pronier, P Cifani, TR Merlinsky, KB Berman, AVH Somasundara, ...
JCI insight 3 (22), 2018
Affinity proteomics to study endogenous protein complexes: pointers, pitfalls, preferences and perspectives
J LaCava, KR Molloy, MS Taylor, M Domanski, BT Chait, MP Rout
BioTechniques 58 (3), 103-119, 2015
Expression and detection of LINE-1 ORF-encoded proteins
L Dai, J LaCava, MS Taylor, JD Boeke
Mobile genetic elements 4 (3), 1034-48, 2014
LINE-1 ORF2p expression is nearly imperceptible in human cancers
D Ardeljan, X Wang, M Oghbaie, MS Taylor, D Husband, V Deshpande, ...
Mobile dna 11, 1-19, 2020
Protein complex purification by affinity capture
J LaCava, J Fernandez-Martinez, Z Hakhverdyan, MP Rout
Cold Spring Harbor Protocols 2016 (7), pdb. top077545, 2016
The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity
A Santanach, E Blanco, H Jiang, KR Molloy, M Sansó, J LaCava, L Morey, ...
Nature communications 8 (1), 1235, 2017
Characterizing ZC3H18, a multi-domain protein at the interface of RNA production and destruction decisions
K Winczura, M Schmid, C Iasillo, KR Molloy, LM Harder, JS Andersen, ...
Cell reports 22 (1), 44-58, 2018
Protein complex affinity capture from cryomilled mammalian cells
J LaCava, H Jiang, MP Rout
JoVE (Journal of Visualized Experiments), e54518, 2016
High prevalence and disease correlation of autoantibodies against p40 encoded by long interspersed nuclear elements in systemic lupus erythematosus
V Carter, J LaCava, MS Taylor, SY Liang, C Mustelin, KC Ukadike, ...
Arthritis & Rheumatology 72 (1), 89-99, 2020
Characterization of L1-ribonucleoprotein particles
MS Taylor, J LaCava, L Dai, P Mita, KH Burns, MP Rout, JD Boeke
Transposons and Retrotransposons: Methods and Protocols, 311-338, 2016
LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint
W McKerrow, X Wang, C Mendez-Dorantes, P Mita, S Cao, M Grivainis, ...
Proceedings of the National Academy of Sciences 119 (8), e2115999119, 2022
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