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Brian PH Metzger
Brian PH Metzger
Department of Biological Sciences, Purdue University
Verified email at purdue.edu - Homepage
Title
Cited by
Cited by
Year
Selection on noise constrains variation in a eukaryotic promoter
BPH Metzger, DC Yuan, JD Gruber, F Duveau, PJ Wittkopp
Nature 521 (7552), 344-347, 2015
1592015
Contrasting Frequencies and Effects of cis- and trans-Regulatory Mutations Affecting Gene Expression
BPH Metzger, F Duveau, DC Yuan, S Tryban, B Yang, PJ Wittkopp
Molecular biology and evolution 33 (5), 1131-1146, 2016
952016
A hydrophobic ratchet entrenches molecular complexes
GKA Hochberg, Y Liu, EG Marklund, BPH Metzger, A Laganowsky, ...
Nature 588 (7838), 503-508, 2020
832020
Evolutionary dynamics of regulatory changes underlying gene expression divergence among Saccharomyces species
BPH Metzger, PJ Wittkopp, J Coolon
Genome biology and evolution 9 (4), 843-854, 2017
742017
Fitness effects of altering gene expression noise in Saccharomyces cerevisiae
F Duveau, A Hodgins-Davis, BPH Metzger, B Yang, S Tryban, EA Walker, ...
Elife 7, e37272, 2018
642018
Epistatic drift causes gradual decay of predictability in protein evolution
Y Park, BPH Metzger, JW Thornton
Science 376 (6595), 823-830, 2022
412022
Deciphering the genic basis of yeast fitness variation by simultaneous forward and reverse genetics
CJ Maclean, BPH Metzger, JR Yang, WC Ho, B Moyers, J Zhang
Molecular biology and evolution 34 (10), 2486-2502, 2017
38*2017
Contingency and chance erase necessity in the experimental evolution of ancestral proteins
VC Xie, J Pu, BPH Metzger, JW Thornton, BC Dickinson
Elife 10, e67336, 2021
372021
Mapping Small Effect Mutations in Saccharomyces cerevisiae: Impacts of Experimental Design and Mutational Properties
F Duveau, BPH Metzger, JD Gruber, K Mack, N Sood, TE Brooks, ...
G3: Genes, Genomes, Genetics 4 (7), 1205-1216, 2014
282014
Compensatory trans-regulatory alleles minimizing variation in TDH3 expression are common within Saccharomyces cerevisiae
BPH Metzger, PJ Wittkopp
Evolution letters 3 (5), 448-461, 2019
252019
Effects of mutation and selection on plasticity of a promoter activity in Saccharomyces cerevisiae
F Duveau, DC Yuan, BPH Metzger, A Hodgins-Davis, PJ Wittkopp
Proceedings of the National Academy of Sciences 114 (52), E11218-E11227, 2017
252017
Mutational sources of trans-regulatory variation affecting gene expression in Saccharomyces cerevisiae
F Duveau, PV Zande, BPH Metzger, CJ Diaz, EA Walker, S Tryban, ...
Elife 10, e67806, 2021
122021
The simplicity of protein sequence-function relationships
Y Park, BPH Metzger, JW Thornton
bioRxiv, 2023
72023
Epistasis facilitates functional evolution in an ancient transcription factor
BPH Metzger, Y Park, TN Starr, JW Thornton
bioRxiv, 2023.04. 19.537271, 2023
42023
Direct sequencing of haplotypes from diploid individuals through a modified emulsion PCR‐based single‐molecule sequencing approach
BPH Metzger, GW Gelembiuk, CE Lee
Molecular ecology resources 13 (1), 135-143, 2013
12013
Chance, contingency, and necessity in the experimental evolution of ancestral proteins
VC Xie, J Pu, BPH Metzger, JW Thornton, BC Dickinson
bioRxiv, 2020.08. 29.273581, 2020
2020
Disentangling the effects of mutation and selection on the evolution of gene expression
BPH Metzger
University of Michigan, 2015
2015
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Articles 1–17