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Qingming Fang
Qingming Fang
Assistant Professor of Biochemistry and Structural Biology, Greehey Children's Cancer Research
Verifierad e-postadress på uthscsa.edu
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HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β
Q Fang, B Inanc, S Schamus, X Wang, L Wei, AR Brown, D Svilar, ...
Nature communications 5 (1), 5513, 2014
1142014
Human variants of O6-alkylguanine-DNA alkyltransferase
AE Pegg, Q Fang, NA Loktionova
DNA repair 6 (8), 1071-1078, 2007
872007
Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase
H Zang, Q Fang, AE Pegg, FP Guengerich
Journal of Biological Chemistry 280 (35), 30873-30881, 2005
842005
O 6-Alkylguanine-DNA alkyltransferase: Low p K a and high reactivity of cysteine 145
FP Guengerich, Q Fang, L Liu, DL Hachey, AE Pegg
Biochemistry 42 (37), 10965-10970, 2003
812003
Cross-Linking of the DNA Repair Protein O6-Alkylguanine DNA Alkyltransferase to DNA in the Presence of Antitumor Nitrogen Mustards
R Loeber, E Michaelson, Q Fang, C Campbell, AE Pegg, N Tretyakova
Chemical research in toxicology 21 (4), 787-795, 2008
782008
Enzyme mechanism-based, oxidative DNA–protein cross-links formed with DNA polymerase β in vivo
JL Quiñones, U Thapar, K Yu, Q Fang, RW Sobol, B Demple
Proceedings of the National Academy of Sciences 112 (28), 8602-8607, 2015
762015
The repair of the tobacco specific nitrosamine derived adduct O 6-[4-oxo-4-(3-pyridyl) butyl] guanine by O 6-alkylguanine-DNA alkyltransferase variants
RS Mijal, NM Thomson, NL Fleischer, GT Pauly, RC Moschel, S Kanugula, ...
Chemical research in toxicology 17 (3), 424-434, 2004
762004
Cross-Linking of the Human DNA Repair Protein O6-Alkylguanine DNA Alkyltransferase to DNA in the Presence of 1,2,3,4-Diepoxybutane
R Loeber, M Rajesh, Q Fang, AE Pegg, N Tretyakova
Chemical research in toxicology 19 (5), 645-654, 2006
722006
Function of domains of human O 6-alkylguanine-DNA alkyltransferase
Q Fang, S Kanugula, AE Pegg
Biochemistry 44 (46), 15396-15405, 2005
712005
Repair of O6-G-Alkyl-O6-G Interstrand Cross-Links by Human O6-Alkylguanine-DNA Alkyltransferase
Q Fang, AM Noronha, SP Murphy, CJ Wilds, JL Tubbs, JA Tainer, ...
Biochemistry 47 (41), 10892-10903, 2008
602008
Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase
S Bale, MM Lopez, GI Makhatadze, Q Fang, AE Pegg, SE Ealick
Biochemistry 47 (50), 13404-13417, 2008
492008
The base excision repair pathway is required for efficient lentivirus integration
KE Yoder, A Espeseth, X Wang, Q Fang, MT Russo, RS Lloyd, D Hazuda, ...
PloS one 6 (3), e17862, 2011
472011
DNA Sequence Context Affects Repair of the Tobacco-Specific Adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by Human O6-Alkylguanine-DNA Alkyltransferases
RS Mijal, S Kanugula, CC Vu, Q Fang, AE Pegg, LA Peterson
Cancer research 66 (9), 4968-4974, 2006
402006
Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations
MD Bacolod, SP Johnson, AE Pegg, ME Dolan, RC Moschel, NS Bullock, ...
Molecular cancer therapeutics 3 (9), 1127-1135, 2004
402004
Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD+/SIRT6 axis
CA Koczor, KM Saville, JF Andrews, J Clark, Q Fang, J Li, ...
Cell reports 37 (5), 2021
372021
Synthesis and characterization of an O 6-2′-deoxyguanosine-alkyl-O 6-2′-deoxyguanosine interstrand cross-link in a 5′-GNC motif and repair by human O 6-alkylguanine-DNA …
FP McManus, Q Fang, JDM Booth, AM Noronha, AE Pegg, CJ Wilds
Organic & Biomolecular Chemistry 8 (19), 4414-4426, 2010
362010
Repair of O4-alkylthymine by O6-alkylguanine-DNA alkyltransferases
Q Fang, S Kanugula, JL Tubbs, JA Tainer, AE Pegg
Journal of biological chemistry 285 (11), 8185-8195, 2010
352010
Substitution of Aminomethyl at the Meta-Position Enhances the Inactivation of O6-Alkylguanine-DNA Alkyltransferase by O6-Benzylguanine
GT Pauly, NA Loktionova, Q Fang, SL Vankayala, WC Guida, AE Pegg
Journal of medicinal chemistry 51 (22), 7144-7153, 2008
352008
Prevention of chemical carcinogen DNA binding and inhibition of nuclear RNA polymerase activity by organosulfur compounds as the possible mechanisms for their anticancer …
FL Yu, W Bender, Q Fang, A Ludeke, B Welch
Cancer Detection and Prevention 27 (5), 370-379, 2003
312003
O6-Alkylguanine−DNA Alkyltransferases Repair O6-Methylguanine in DNA with Michaelis−Menten-like Kinetics
AS Meyer, MD McCain, Q Fang, AE Pegg, TE Spratt
Chemical research in toxicology 16 (11), 1405-1409, 2003
292003
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Artiklar 1–20