Irina Tikhonova
Irina Tikhonova
Queen's University Belfast, NIH, INSERM, MSU
No verified email
Cited by
Cited by
Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment
I Kufareva, M Rueda, V Katritch, participants GPCR-Dock-2010, ...
Structure 19 (8), 1108-1126, 2011
Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment: Meeting New Challenges
I Kufareva, V Katritch, PGD 2013, RC Stevens, R Abagyan
Structure, 2014
Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening
IG Tikhonova, CS Sum, S Neumann, S Engel, BM Raaka, S Costanzi, ...
Journal of medicinal chemistry 51 (3), 625-633, 2008
Identification of residues important for agonist recognition and activation in GPR40
CS Sum, IG Tikhonova, S Neumann, S Engel, BM Raaka, S Costanzi, ...
Journal of Biological Chemistry 282 (40), 29248-29255, 2007
Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3
BD Hudson, IG Tikhonova, SK Pandey, T Ulven, G Milligan
Journal of Biological Chemistry 287 (49), 41195-41209, 2012
Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3
J Schmidt, NJ Smith, E Christiansen, IG Tikhonova, M Grundmann, ...
Journal of Biological Chemistry 286 (12), 10628-10640, 2011
Bidirectional, iterative approach to the structural delineation of the functional “chemoprint” in GPR40 for agonist recognition
IG Tikhonova, CS Sum, S Neumann, CJ Thomas, BM Raaka, S Costanzi, ...
Journal of medicinal chemistry 50 (13), 2981-2989, 2007
Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor
BD Hudson, ME Due-Hansen, E Christiansen, AM Hansen, AE Mackenzie, ...
Journal of Biological Chemistry 288 (24), 17296-17312, 2013
Rhodopsin and the others: a historical perspective on structural studies of G protein-coupled receptors
S Costanzi, J Siegel, IG Tikhonova, KA Jacobson
Current pharmaceutical design 15 (35), 3994-4002, 2009
Old drug, new target: ellipticines selectively inhibit RNA polymerase I transcription
WJ Andrews, T Panova, C Normand, O Gadal, IG Tikhonova, KI Panov
Journal of Biological Chemistry 288 (7), 4567-4582, 2013
Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs
BD Hudson, E Christiansen, IG Tikhonova, M Grundmann, E Kostenis, ...
The FASEB Journal 26 (12), 4951, 2012
Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator
NJ Smith, RJ Ward, LA Stoddart, BD Hudson, E Kostenis, T Ulven, ...
Molecular pharmacology 80 (1), 163-173, 2011
Two arginine-glutamate ionic locks near the extracellular surface of FFAR1 gate receptor activation
CS Sum, IG Tikhonova, S Costanzi, MC Gershengorn
Journal of biological chemistry 284 (6), 3529-3536, 2009
Identification of determinants of glucose-dependent insulinotropic polypeptide receptor that interact with N-terminal biologically active region of the natural ligand
T Yaqub, IG Tikhonova, J Lättig, R Magnan, M Laval, C Escrieut, ...
Molecular pharmacology 77 (4), 547-558, 2010
Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors
X Chen, IG Tikhonova, M Decker
Bioorganic & medicinal chemistry 19 (3), 1222-1235, 2011
Simulations of Biased Agonists in the β2 Adrenergic Receptor with Accelerated Molecular Dynamics
IG Tikhonova, B Selvam, A Ivetac, J Wereszczynski, JA McCammon
Biochemistry 52 (33), 5593-5603, 2013
Structural basis for understanding structure− activity relationships for the glutamate binding site of the NMDA receptor
IG Tikhonova, II Baskin, VA Palyulin, NS Zefirov, SO Bachurin
Journal of medicinal chemistry 45 (18), 3836-3843, 2002
Modeled structure of a G-protein-coupled receptor: the cholecystokinin-1 receptor
E Archer-Lahlou, I Tikhonova, C Escrieut, M Dufresne, C Seva, ...
Journal of medicinal chemistry 48 (1), 180-191, 2005
Insights into the binding and activation sites of the receptors for cholecystokinin and gastrin
M Foucaud, E Archer-Lahlou, E Marco, IG Tikhonova, B Maigret, ...
Regulatory peptides 145 (1-3), 17-23, 2008
Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84
ZA Mahmud, L Jenkins, T Ulven, F Labéguère, R Gosmini, S De Vos, ...
Scientific reports 7 (1), 17953, 2017
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