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Irina Tikhonova
Irina Tikhonova
Queen's University Belfast, NIH, INSERM, MSU
No verified email
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Cited by
Cited by
Year
Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment
I Kufareva, M Rueda, V Katritch, participants GPCR-Dock-2010, ...
Structure 19 (8), 1108-1126, 2011
3462011
Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment: Meeting New Challenges
I Kufareva, V Katritch, PGD 2013, RC Stevens, R Abagyan
Structure, 2014
1812014
Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening
IG Tikhonova, CS Sum, S Neumann, S Engel, BM Raaka, S Costanzi, ...
Journal of medicinal chemistry 51 (3), 625-633, 2008
1712008
Identification of residues important for agonist recognition and activation in GPR40
CS Sum, IG Tikhonova, S Neumann, S Engel, BM Raaka, S Costanzi, ...
Journal of Biological Chemistry 282 (40), 29248-29255, 2007
1412007
Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3
BD Hudson, IG Tikhonova, SK Pandey, T Ulven, G Milligan
Journal of Biological Chemistry 287 (49), 41195-41209, 2012
1302012
Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3
J Schmidt, NJ Smith, E Christiansen, IG Tikhonova, M Grundmann, ...
Journal of Biological Chemistry 286 (12), 10628-10640, 2011
1282011
Bidirectional, iterative approach to the structural delineation of the functional “chemoprint” in GPR40 for agonist recognition
IG Tikhonova, CS Sum, S Neumann, CJ Thomas, BM Raaka, S Costanzi, ...
Journal of medicinal chemistry 50 (13), 2981-2989, 2007
1122007
Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor
BD Hudson, ME Due-Hansen, E Christiansen, AM Hansen, AE Mackenzie, ...
Journal of Biological Chemistry 288 (24), 17296-17312, 2013
1052013
Rhodopsin and the others: a historical perspective on structural studies of G protein-coupled receptors
S Costanzi, J Siegel, IG Tikhonova, KA Jacobson
Current pharmaceutical design 15 (35), 3994-4002, 2009
852009
Old drug, new target: ellipticines selectively inhibit RNA polymerase I transcription
WJ Andrews, T Panova, C Normand, O Gadal, IG Tikhonova, KI Panov
Journal of Biological Chemistry 288 (7), 4567-4582, 2013
812013
Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs
BD Hudson, E Christiansen, IG Tikhonova, M Grundmann, E Kostenis, ...
The FASEB Journal 26 (12), 4951, 2012
812012
Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator
NJ Smith, RJ Ward, LA Stoddart, BD Hudson, E Kostenis, T Ulven, ...
Molecular pharmacology 80 (1), 163-173, 2011
792011
Two arginine-glutamate ionic locks near the extracellular surface of FFAR1 gate receptor activation
CS Sum, IG Tikhonova, S Costanzi, MC Gershengorn
Journal of biological chemistry 284 (6), 3529-3536, 2009
652009
Identification of determinants of glucose-dependent insulinotropic polypeptide receptor that interact with N-terminal biologically active region of the natural ligand
T Yaqub, IG Tikhonova, J Lättig, R Magnan, M Laval, C Escrieut, ...
Molecular pharmacology 77 (4), 547-558, 2010
642010
Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors
X Chen, IG Tikhonova, M Decker
Bioorganic & medicinal chemistry 19 (3), 1222-1235, 2011
592011
Simulations of Biased Agonists in the β2 Adrenergic Receptor with Accelerated Molecular Dynamics
IG Tikhonova, B Selvam, A Ivetac, J Wereszczynski, JA McCammon
Biochemistry 52 (33), 5593-5603, 2013
542013
Structural basis for understanding structure− activity relationships for the glutamate binding site of the NMDA receptor
IG Tikhonova, II Baskin, VA Palyulin, NS Zefirov, SO Bachurin
Journal of medicinal chemistry 45 (18), 3836-3843, 2002
542002
Modeled structure of a G-protein-coupled receptor: the cholecystokinin-1 receptor
E Archer-Lahlou, I Tikhonova, C Escrieut, M Dufresne, C Seva, ...
Journal of medicinal chemistry 48 (1), 180-191, 2005
522005
Insights into the binding and activation sites of the receptors for cholecystokinin and gastrin
M Foucaud, E Archer-Lahlou, E Marco, IG Tikhonova, B Maigret, ...
Regulatory peptides 145 (1-3), 17-23, 2008
502008
Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84
ZA Mahmud, L Jenkins, T Ulven, F Labéguère, R Gosmini, S De Vos, ...
Scientific reports 7 (1), 17953, 2017
472017
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Articles 1–20