A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases MN Lisa, AR Palacios, M Aitha, MM González, DM Moreno, MW Crowder, ... Nature communications 8 (1), 538, 2017 | 127 | 2017 |
Mechanistic and spectroscopic studies of metallo-β-lactamase NDM-1 H Yang, M Aitha, AM Hetrick, TK Richmond, DL Tierney, MW Crowder Biochemistry 51 (18), 3839-3847, 2012 | 122 | 2012 |
Spectroscopic and mechanistic studies of heterodimetallic forms of metallo-β-lactamase NDM-1 H Yang, M Aitha, AR Marts, A Hetrick, B Bennett, MW Crowder, ... Journal of the American Chemical Society 136 (20), 7273-7285, 2014 | 81 | 2014 |
Biochemical, Mechanistic, and Spectroscopic Characterization of Metallo-β-lactamase VIM-2 M Aitha, AR Marts, A Bergstrom, AJ Moeller, L Moritz, L Turner, JC Nix, ... Biochemistry 53 (46), 7321-7331, 2014 | 70 | 2014 |
Probing the Interaction of Aspergillomarasmine A with Metallo-β-lactamases NDM-1, VIM-2, and IMP-7 A Bergstrom, A Katko, Z Adkins, J Hill, Z Cheng, M Burnett, H Yang, ... ACS infectious diseases 4 (2), 135-145, 2018 | 57 | 2018 |
Investigating the position of the hairpin loop in New Delhi metallo-β-lactamase, NDM-1, during catalysis and inhibitor binding M Aitha, AJ Moller, ID Sahu, M Horitani, DL Tierney, MW Crowder Journal of inorganic biochemistry 156, 35-39, 2016 | 31 | 2016 |
Replication protein A dynamically regulates monoubiquitination of proliferating cell nuclear antigen M Hedglin, M Aitha, A Pedley, SJ Benkovic Journal of biological chemistry 294 (13), 5157-5168, 2019 | 30 | 2019 |
New β-phospholactam as a carbapenem transition state analog: synthesis of a broad-spectrum inhibitor of metallo-β-lactamases KW Yang, L Feng, SK Yang, M Aitha, AE LaCuran, P Oelschlaeger, ... Bioorganic & medicinal chemistry letters 23 (21), 5855-5859, 2013 | 29 | 2013 |
Conformational dynamics of metallo-β-lactamase CcrA during catalysis investigated by using DEER spectroscopy M Aitha, L Moritz, ID Sahu, O Sanyurah, Z Roche, R McCarrick, ... Journal of Biological Inorganic Chemistry 20, 2015 | 21 | 2015 |
Metal ion dependence of the matrix metalloproteinase-1 mechanism H Yang, K Makaroff, N Paz, M Aitha, MW Crowder, DL Tierney Biochemistry 54 (23), 3631-3639, 2015 | 16 | 2015 |
Dilution of dipolar interactions in a spin-labeled, multimeric metalloenzyme for DEER studies M Aitha, TK Richmond, Z Hu, A Hetrick, R Reese, A Gunther, R McCarrick, ... Journal of inorganic biochemistry 136, 40-46, 2014 | 16 | 2014 |
Monitoring the retention of human proliferating cell nuclear antigen at primer/template junctions by proteins that bind single-stranded DNA M Hedglin, M Aitha, SJ Benkovic Biochemistry 56 (27), 3415-3421, 2017 | 14 | 2017 |
Meropenem and chromacef intermediates observed in IMP-25 metallo-β-lactamase-catalyzed hydrolysis P Oelschlaeger, M Aitha, H Yang, JS Kang, AL Zhang, EM Liu, JD Buynak, ... Antimicrobial Agents and Chemotherapy 59 (7), 4326-4330, 2015 | 13 | 2015 |
Serum-stable and selective backbone-N-methylated cyclic peptides that inhibit prokaryotic glycolytic mutases RHP Van Neer, PK Dranchak, L Liu, M Aitha, B Queme, H Kimura, ... ACS chemical biology 17 (8), 2284-2295, 2022 | 12 | 2022 |
A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-beta-lactamases. Nat Commun 8: 538 MN Lisa, AR Palacios, M Aitha, MM González, DM Moreno, MW Crowder, ... | 10 | 2017 |
Reactions of Zn 2, Cd 2 and Hg 2 with Free Adenine YZ Hamadaa, T Burkeyb, E Waddellc, M Aithad, N Phambud Journal of Applied Solution Chemistry and Modeling 2, 77-84, 2013 | 10 | 2013 |
Probing substrate binding to the metal binding sites in metallo-β-lactamase L1 during catalysis M Aitha, S Al-Adbul-Wahid, DL Tierney, MW Crowder MedChemComm 7 (1), 194-201, 2016 | 8 | 2016 |
Mechanism-based cephalosporin inhibitors of metallo-and serine-carbapenemases LD Sutton, S Yu, A Yu, M Yu, M Aitha, M Crowder, N Zhou, M Broderick, ... Interscience Conference on Antimicrobial Agents and Chemotherapy, 2013 | 6 | 2013 |
HME A Bergstrom, A Katko, Z Adkins, J Hill, Z Cheng, M Burnett, H Yang, ... Martin, NI, Bonomo, RA, Page, RC, Tierney, DL, Fast, W., Wright, GD, and …, 2018 | 4 | 2018 |
Structure–activity relationship of ipglycermide binding to phosphoglycerate mutases M Wiedmann, PK Dranchak, M Aitha, B Queme, CD Collmus, ... Journal of Biological Chemistry 296, 2021 | 3 | 2021 |