Thomas A Milne
Thomas A Milne
University of Oxford, Weatherall Institute of Molecular Medicine
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A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling
J Wysocka, T Swigut, H Xiao, TA Milne, SY Kwon, J Landry, M Kauer, ...
Nature 442 (7098), 86-90, 2006
MLL targets SET domain methyltransferase activity to Hox gene promoters
TA Milne, SD Briggs, HW Brock, ME Martin, D Gibbs, CD Allis, JL Hess
Molecular cell 10 (5), 1107-1117, 2002
WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development
J Wysocka, T Swigut, TA Milne, Y Dou, X Zhang, AL Burlingame, ...
Cell 121 (6), 859-872, 2005
Regulation of MLL1 H3K4 methyltransferase activity by its core components
Y Dou, TA Milne, AJ Ruthenburg, S Lee, JW Lee, GL Verdine, CD Allis, ...
Nature structural & molecular biology 13 (8), 713-719, 2006
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
Y Dou, TA Milne, AJ Tackett, ER Smith, A Fukuda, J Wysocka, CD Allis, ...
Cell 121 (6), 873-885, 2005
Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus
CM Hughes, O Rozenblatt-Rosen, TA Milne, TD Copeland, SS Levine, ...
Molecular cell 13 (4), 587-597, 2004
RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells
J Kim, M Guermah, RK McGinty, JS Lee, Z Tang, TA Milne, A Shilatifard, ...
Cell 137 (3), 459-471, 2009
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors
TA Milne, CM Hughes, R Lloyd, Z Yang, O Rozenblatt-Rosen, Y Dou, ...
Proceedings of the National Academy of Sciences 102 (3), 749-754, 2005
Hoxa9 and Meis1 Are Key Targets for MLL-ENL-Mediated Cellular Immortalization
BB Zeisig, T Milne, MP García-Cuéllar, S Schreiner, ME Martin, U Fuchs, ...
Molecular and cellular biology 24 (2), 617-628, 2004
Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions
AJ Ruthenburg, H Li, TA Milne, S Dewell, RK McGinty, M Yuen, ...
Cell 145 (5), 692-706, 2011
Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia
A Akalin, FE Garrett-Bakelman, M Kormaksson, J Busuttil, L Zhang, ...
PLoS genetics 8 (6), e1002781, 2012
Regulation of hippocampal H3 histone methylation by acute and chronic stress
RG Hunter, KJ McCarthy, TA Milne, DW Pfaff, BS McEwen
Proceedings of the National Academy of Sciences 106 (49), 20912-20917, 2009
Intragenic enhancers act as alternative promoters
MS Kowalczyk, JR Hughes, D Garrick, MD Lynch, JA Sharpe, ...
Molecular cell 45 (4), 447-458, 2012
MLL associates specifically with a subset of transcriptionally active target genes
TA Milne, Y Dou, ME Martin, HW Brock, RG Roeder, JL Hess
Proceedings of the National Academy of Sciences 102 (41), 14765-14770, 2005
Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis
TA Milne, J Kim, GG Wang, SC Stadler, V Basrur, SJ Whitcomb, Z Wang, ...
Molecular cell 38 (6), 853-863, 2010
Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression
Z Wang, J Song, TA Milne, GG Wang, H Li, CD Allis, DJ Patel
Cell 141 (7), 1183-1194, 2010
Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications
TA Milne, ME Martin, HW Brock, RK Slany, JL Hess
Cancer research 65 (24), 11367-11374, 2005
MLL-AF9 expression in hematopoietic stem cells drives a highly invasive AML expressing EMT-related genes linked to poor outcome
V Stavropoulou, S Kaspar, L Brault, MA Sanders, S Juge, S Morettini, ...
Cancer cell 30 (1), 43-58, 2016
Interaction of MLL amino terminal sequences with menin is required for transformation
C Caslini, Z Yang, M El-Osta, TA Milne, RK Slany, JL Hess
Cancer research 67 (15), 7275-7283, 2007
Metabolic gatekeeper function of B-lymphoid transcription factors
LN Chan, Z Chen, D Braas, JW Lee, G Xiao, H Geng, KN Cosgun, C Hurtz, ...
Nature 542 (7642), 479-483, 2017
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