| Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time M Aleksic, O Dushek, H Zhang, E Shenderov, JL Chen, V Cerundolo, ... Immunity 32 (2), 163-174, 2010 | 300 | 2010 |
| Modelling the combined impact of interventions in averting deaths during a synthetic‐opioid overdose epidemic MA Irvine, M Kuo, JA Buxton, R Balshaw, M Otterstatter, L Macdougall, ... Addiction 114 (9), 1602-1613, 2019 | 208 | 2019 |
| T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell PA González, LJ Carreño, D Coombs, JE Mora, E Palmieri, B Goldstein, ... Proceedings of the National Academy of Sciences 102 (13), 4824-4829, 2005 | 183 | 2005 |
| An age-structured model of HIV infection that allows for variations in the production rate of viral particles and the death rate of productively infected cells PW Nelson, MA Gilchrist, D Coombs, JM Hyman, AS Perelson Mathematical Biosciences & Engineering 1 (2), 267-288, 2004 | 178 | 2004 |
| Activated TCRs remain marked for internalization after dissociation from pMHC D Coombs, AM Kalergis, SG Nathenson, C Wofsy, B Goldstein Nature immunology 3 (10), 926-931, 2002 | 169 | 2002 |
| Evolution of virulence: interdependence, constraints, and selection using nested models MA Gilchrist, D Coombs Theoretical population biology 69 (2), 145-153, 2006 | 163 | 2006 |
| Evaluating the importance of within-and between-host selection pressures on the evolution of chronic pathogens D Coombs, MA Gilchrist, CL Ball Theoretical population biology 72 (4), 576-591, 2007 | 159 | 2007 |
| A hidden Markov model for single particle tracks quantifies dynamic interactions between LFA-1 and the actin cytoskeleton R Das, CW Cairo, D Coombs PLoS computational biology 5 (11), e1000556, 2009 | 158 | 2009 |
| The influence of transport on the kinetics of binding to surface receptors: application to cells and BIAcore B Goldstein, D Coombs, X He, AR Pineda, C Wofsy Journal of molecular recognition 12 (5), 293-299, 1999 | 138 | 1999 |
| Diffusion on a sphere with localized traps: Mean first passage time, eigenvalue asymptotics, and Fekete points D Coombs, R Straube, M Ward SIAM Journal on Applied Mathematics 70 (1), 302-332, 2009 | 123 | 2009 |
| Optimizing within-host viral fitness: infected cell lifespan and virion production rate MA Gilchrist, D Coombs, AS Perelson Journal of theoretical biology 229 (2), 281-288, 2004 | 114 | 2004 |
| Quantifying the impact of COVID-19 control measures using a Bayesian model of physical distancing SC Anderson, AM Edwards, M Yerlanov, N Mulberry, JE Stockdale, ... PLoS computational biology 16 (12), e1008274, 2020 | 109 | 2020 |
| Distribution of take-home opioid antagonist kits during a synthetic opioid epidemic in British Columbia, Canada: a modelling study MA Irvine, JA Buxton, M Otterstatter, R Balshaw, R Gustafson, M Tyndall, ... The Lancet Public Health 3 (5), e218-e225, 2018 | 109 | 2018 |
| A stochastic model of latently infected cell reactivation and viral blip generation in treated HIV patients JM Conway, D Coombs PLoS computational biology 7 (4), e1002033, 2011 | 107 | 2011 |
| Equilibrium thermodynamics of cell-cell adhesion mediated by multiple ligand-receptor pairs D Coombs, M Dembo, C Wofsy, B Goldstein Biophysical journal 86 (3), 1408-1423, 2004 | 106 | 2004 |
| Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor SA Freeman, V Jaumouillé, K Choi, BE Hsu, HS Wong, L Abraham, ... Nature communications 6 (1), 6168, 2015 | 104 | 2015 |
| A role for rebinding in rapid and reliable T cell responses to antigen O Dushek, R Das, D Coombs PLoS computational biology 5 (11), e1000578, 2009 | 96 | 2009 |
| Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation O Dushek, M Aleksic, RJ Wheeler, H Zhang, SP Cordoba, YC Peng, ... Science signaling 4 (176), ra39-ra39, 2011 | 94 | 2011 |
| Mechanical force regulates integrin turnover in Drosophila in vivo M Pines, R Das, SJ Ellis, A Morin, S Czerniecki, L Yuan, M Klose, ... Nature cell biology 14 (9), 935-943, 2012 | 87 | 2012 |
| Calculations show substantial serial engagement of T cell receptors C Wofsy, D Coombs, B Goldstein Biophysical journal 80 (2), 606-612, 2001 | 86 | 2001 |
MA IrvineBC Centre for Disease ControlVerified email at bccdc.ca
