Daniel Coombs
Daniel Coombs
Professor, Mathematics, University of British Columbia
Verified email at - Homepage
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Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time
M Aleksic, O Dushek, H Zhang, E Shenderov, JL Chen, V Cerundolo, ...
Immunity 32 (2), 163-174, 2010
Modelling the combined impact of interventions in averting deaths during a synthetic‐opioid overdose epidemic
MA Irvine, M Kuo, JA Buxton, R Balshaw, M Otterstatter, L Macdougall, ...
Addiction 114 (9), 1602-1613, 2019
T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell
PA González, LJ Carreño, D Coombs, JE Mora, E Palmieri, B Goldstein, ...
Proceedings of the National Academy of Sciences 102 (13), 4824-4829, 2005
An age-structured model of HIV infection that allows for variations in the production rate of viral particles and the death rate of productively infected cells
PW Nelson, MA Gilchrist, D Coombs, JM Hyman, AS Perelson
Mathematical Biosciences & Engineering 1 (2), 267-288, 2004
Activated TCRs remain marked for internalization after dissociation from pMHC
D Coombs, AM Kalergis, SG Nathenson, C Wofsy, B Goldstein
Nature immunology 3 (10), 926-931, 2002
Evolution of virulence: interdependence, constraints, and selection using nested models
MA Gilchrist, D Coombs
Theoretical population biology 69 (2), 145-153, 2006
Evaluating the importance of within-and between-host selection pressures on the evolution of chronic pathogens
D Coombs, MA Gilchrist, CL Ball
Theoretical population biology 72 (4), 576-591, 2007
A hidden Markov model for single particle tracks quantifies dynamic interactions between LFA-1 and the actin cytoskeleton
R Das, CW Cairo, D Coombs
PLoS computational biology 5 (11), e1000556, 2009
The influence of transport on the kinetics of binding to surface receptors: application to cells and BIAcore
B Goldstein, D Coombs, X He, AR Pineda, C Wofsy
Journal of molecular recognition 12 (5), 293-299, 1999
Diffusion on a sphere with localized traps: Mean first passage time, eigenvalue asymptotics, and Fekete points
D Coombs, R Straube, M Ward
SIAM Journal on Applied Mathematics 70 (1), 302-332, 2009
Optimizing within-host viral fitness: infected cell lifespan and virion production rate
MA Gilchrist, D Coombs, AS Perelson
Journal of theoretical biology 229 (2), 281-288, 2004
Equilibrium thermodynamics of cell-cell adhesion mediated by multiple ligand-receptor pairs
D Coombs, M Dembo, C Wofsy, B Goldstein
Biophysical journal 86 (3), 1408-1423, 2004
Quantifying the impact of COVID-19 control measures using a Bayesian model of physical distancing
SC Anderson, AM Edwards, M Yerlanov, N Mulberry, JE Stockdale, ...
PLoS computational biology 16 (12), e1008274, 2020
Distribution of take-home opioid antagonist kits during a synthetic opioid epidemic in British Columbia, Canada: a modelling study
MA Irvine, JA Buxton, M Otterstatter, R Balshaw, R Gustafson, M Tyndall, ...
The Lancet Public Health 3 (5), e218-e225, 2018
Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor
SA Freeman, V Jaumouillé, K Choi, BE Hsu, HS Wong, L Abraham, ...
Nature communications 6 (1), 6168, 2015
A stochastic model of latently infected cell reactivation and viral blip generation in treated HIV patients
JM Conway, D Coombs
PLoS computational biology 7 (4), e1002033, 2011
A role for rebinding in rapid and reliable T cell responses to antigen
O Dushek, R Das, D Coombs
PLoS computational biology 5 (11), e1000578, 2009
Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation
O Dushek, M Aleksic, RJ Wheeler, H Zhang, SP Cordoba, YC Peng, ...
Science signaling 4 (176), ra39-ra39, 2011
Mechanical force regulates integrin turnover in Drosophila in vivo
M Pines, R Das, SJ Ellis, A Morin, S Czerniecki, L Yuan, M Klose, ...
Nature cell biology 14 (9), 935-943, 2012
Calculations show substantial serial engagement of T cell receptors
C Wofsy, D Coombs, B Goldstein
Biophysical journal 80 (2), 606-612, 2001
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